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the second half of the photolyase homology region (PHR) of CRY (zeige CRY2 ELISA Kits) is important for repression through facilitating interaction with BMAL1
M. tuberculosis infection caused enhanced MMP-1 (zeige MMP1 ELISA Kits), -9, and miR (zeige MLXIP ELISA Kits)-223 expression, with inhibited BMAL1 expression. MiR (zeige MLXIP ELISA Kits)-223 modulated BMAL1 expression via the direct binding of BMAL1 3'-UTR (zeige UTS2R ELISA Kits).
research describes an association between changes in the methylation of the BMAL1 gene with the intervention and the effects of a weight loss intervention on blood lipids levels
Study found rhythmic methylation of BMAL1 was altered in Alzheimer's disease brains and fibroblasts and correlated with transcription cycles. Results indicate that cycles of DNA methylation (zeige HELLS ELISA Kits) contribute to the regulation of BMAL1 rhythms in the brain.
TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1
found that overexpression of both Clock and Bmal1 suppressed cell growth
our results identified Bmal1 as a novel tumor suppressor gene that elevates the sensitivity of cancer cells to paclitaxel, with potential implications as a chronotherapy timing biomarker in tongue squamous cell carcinoma
The level of BMAL1 expression in granulosa cells the polycystic ovary syndrome (PCOS) group was lower than that of the group without PCOS. We also analyzed estrogen synthesis and aromatase (zeige CYP19A1 ELISA Kits) expression in KGN cell lines. Both were downregulated after BMAL1 and SIRT1 (zeige SIRT1 ELISA Kits) knock-down and, conversely, upregulated after overexpression treatments of these two genes in KGN cells.
this study shows that BMAL1 can regulate cellular innate immunity against specific RNA viruses
Bmal1 is a key clock gene to involve in cartilage homeostasis mediated through sirt1 (zeige SIRT1 ELISA Kits).
The BMAL1 rs2278749 T/C was associated with Alzheimer disease (AD) risk, and T carriers in BMAL1 rs2278749 T/C showed a higher risk of AD than did non-carriers.
The Smad3 (zeige SMAD3 ELISA Kits) and Bmal1 regulate p21 and S100A4 (zeige S100A4 ELISA Kits) expression in myocardial stromal fibroblasts through TNF-alpha (zeige TNF ELISA Kits).
Data demonstrated that the circadian rhythm of testosterone synthesis in TM3 (zeige TPM1 ELISA Kits) cells was disturbed following Fen treatment as evidenced by changes in the circadian rhythmicity of core clock genes (Bmal1, Rev-erbalpha (zeige NR1D1 ELISA Kits), Roralpha).
The circadian clock component Bmal1 is involved in blood brain barrier homeostasis.
Study shows a role for Bmal1, the endogenous circadian clock, in glucose metabolism in the skeletal muscle. Findings implicate altered molecular clock dictating significant changes in altered substrate metabolism in the absence of feeding or activity changes.
A significant proportion of circadian lncRNAs are expressed at enhancer regions, mostly bound by two key circadian transcription factors, BMAL1 and REV-ERBalpha (zeige NR1D1 ELISA Kits).
A cis (zeige CISH ELISA Kits)/trans isomerization switch in the BMAL1 transactivation domain controls circadian rhythms. Conformationally locking the switch or inhibiting prolyl isomerases influences circadian period to suggest that slow protein dynamics play a role in timekeeping.
Bmal1 deficiency in macrophages promotes atherosclerosis by enhancing recruitment of Ly6chi monocytes to atherosclerotic lesions.
Bmal1 autophagic degradation and Bmal1 role in glucose homeostasis
These results suggest that miR (zeige MLXIP ELISA Kits)-27b-3p plays an important role in the posttranscriptional regulation of BMAL1 protein in the liver.
Results indicated that pBMAL1 cDNA had a coding region of 1,878 bp and shared 94.36, 89.85 and 89.79% identity with human, mouse and rat BMAL1. pBMAL1 expression levels in different tissues were studied.
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
aryl hydrocarbon receptor nuclear translocator-like protein 1
, brain and muscle Arnt-like protein 1
, aryl hydrocarbon receptor nuclear translocator-like
, Brain and muscle ARNT-like 1
, brain and muscle ARNT-like 1
, aryl hydrocarbon receptor nuclear translocator-like protein 1-like
, aryl hydrocarbon receptor nuclear translocater
, ARNT-like protein 1, brain and muscle
, PAS domain-containing protein 3
, bHLH-PAS protein JAP3
, basic-helix-loop-helix-PAS orphan MOP3
, basic-helix-loop-helix-PAS protein MOP3
, class E basic helix-loop-helix protein 5
, member of PAS protein 3
, member of PAS superfamily 3
, bHLH-PAS transcription factor BMAL1
, clock protein
, brain and muscle ARNT-like protein 1