Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Mouse (Murine) Antikörper:
anti-Rat (Rattus) Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Monoclonal KDM1A Primary Antibody für ChIP, ELISA - ABIN151289
Lim, Janzer, Becker, Zimmer, Schüle, Buettner, Kirfel: Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. in Carcinogenesis 2010
Show all 10 Pubmed References
Human Polyclonal KDM1A Primary Antibody für ELISA, WB - ABIN1002761
Shi, Lan, Matson, Mulligan, Whetstine, Cole, Casero, Shi: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. in Cell 2004
Show all 4 Pubmed References
Human Polyclonal KDM1A Primary Antibody für IHC, ELISA - ABIN1002762
Kouzarides: Histone methylation in transcriptional control. in Current opinion in genetics & development 2002
Show all 4 Pubmed References
Human Polyclonal KDM1A Primary Antibody für IHC (p), ELISA - ABIN542809
Hakimi, Dong, Lane, Speicher, Shiekhattar: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. in The Journal of biological chemistry 2003
Show all 3 Pubmed References
Human Polyclonal KDM1A Primary Antibody für IHC (p), ELISA - ABIN542808
Forneris, Binda, Vanoni, Mattevi, Battaglioli: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. in FEBS letters 2005
Show all 3 Pubmed References
Human Polyclonal KDM1A Primary Antibody für WB - ABIN541519
Nakamura, Mori, Tada, Krajewski, Rozovskaia, Wassell, Dubois, Mazo, Croce, Canaani: ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. in Molecular cell 2002
Show all 3 Pubmed References
Human Monoclonal KDM1A Primary Antibody für IHC (fro), IHC (p) - ABIN537073
Metzger, Wissmann, Yin, Müller, Schneider, Peters, Günther, Buettner, Schüle: LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. in Nature 2005
Show all 2 Pubmed References
Human Monoclonal KDM1A Primary Antibody für IHC, ELISA - ABIN969264
Shi, Matson, Lan, Iwase, Baba, Shi: Regulation of LSD1 histone demethylase activity by its associated factors. in Molecular cell 2005
Show all 2 Pubmed References
Human Monoclonal KDM1A Primary Antibody für IF, IHC (p) - ABIN564989
Chen, Obara, Ishida, Suzuki, Yoshizato: Characterization of histone lysine-specific demethylase in relation to thyroid hormone-regulated anuran metamorphosis. in Development, growth & differentiation 2007
LSD1 coordinates with the SIN3A/HDAC complex in inhibiting a series of genes such as CASP7, TGFB2, CDKN1A(p21), HIF1A, TERT, and MDM2, some of which are oncogenic.
DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes
LSD1 controls senescence in Glioblastoma tumor cells through the regulation of HIF-1alpha.
SET7-mediated UHRF1 methylation is also shown to be essential for cell viability against DNA damage. Our data revealed the regulatory mechanism underlying the UHRF1 methylation status by SET7 and LSD1 in double-strand break repair pathway
This study documents that long-term, moderate hypoxia promotes resistance to the EGFR TKI, gefitinib, in the NSCLC cell line HCC827, which harbors an activating EGFR mutation..Mechanistically, knockdown of LSD1 and PLU-1, prevented and reversed hypoxia-induced gefitinib resistance, suggesting that LSD1 and PLU-1 play key roles in hypoxia-induced gefitinib resistance and epithelial-mesenchymal transition
Data indicated that AFAP1-AS1 plays vital roles in LSD1-mediated HBP1 repression in non-small-cell lung cancer cells.
LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in cancer cells.
LSD1 knockdown group showed a higher differentiation efficiency of induced pluripotent stem cells
The present results suggest that LSD1 is induced by c-Myc and forms a positive feedback mechanism in transcription reactions by c-Myc.
Taken together, these studies indicate that LSD1-mediated RORalpha2 transcriptional activity is important to promote tumor cell migration in human breast cancer as well as breast cancer cell lines.
KDM1A is the first germline autosomal dominant predisposition gene identified in multiple myeloma and provides new insights into multiple myeloma etiology and the mechanistic role of KDM1A as a tumor suppressor during post-germinal center B-cell differentiation.
our data show that LSD1 confers lung adenocarcinoma cells with invasive and dedifferentiated attributes by modulating a non-canonical integrin beta3-KRAS signaling pathway.
The deacetylase selectivity of core CoREST complex (LHC) unexpectedly shows a marked preference for H3 acetyl-Lys9 versus acetyl-Lys14 in nucleosome substrates but this selectivity is lost with isolated acetyl-Lys H3 protein. LHC demethylase activity toward methyl-Lys4 in histone H3 is strongly inhibited by H3 Lys14 acetylation, and this appears to be an intrinsic property of the LSD1 subunit.
our results suggest that KDM1A hypomethylation is significantly associated with colorectal cancer
FOXD2-AS1 acted as a tumor inducer in GC partly through EphB3 inhibition by direct interaction with EZH2 and LSD1.
vitamin B2 induced activation of LSD1 may attenuate the proliferation inhibition, and anti-migration effects of apatinib in gastric cancer cells. These findings suggested that vitamin B supplementation may interfere with the efficacy of apatinib in patients with gastric cancer.
Using a combination of ROS specific dyes, monoamine oxidase inhibitor, LSD1 inhibitor, and LSD1 depletion by siRNA we have found that the oxidase and chromatin remodeling protein Lysine demethylase I (LSD1/KDM1A) generates detectable ROS as a byproduct of its chromatin remodeling activity during the initial DNA damage response.
Results reveal that CAF-induced expression of Notch3 is responsible for LSD1 activation in CSC, driving their self-renewal in HCC. These seminal findings illuminate a complex pathway in the tissue microenvironment of liver cancer, which is responsible for orchestrating the self-renewal of stem-like cancer cells.
The authors demonstrate that the SIX3/LSD1/NuRD(MTA3) complex inhibits carcinogenesis in breast cancer cells and suppresses metastasis in breast cancer.
Data suggest that, in human ovarian teratocarcinoma cell line, methylation-dependent proteolysis of SOX2 is controlled by LSD1 and PHF20L1 via regulation of SET7 activity; these data are consistent with previous studies in mouse primary stem cells. (SOX2 = SRY-box 2 transcription factor; LSD1 = lysine demethylase-1A; PHF20L1 = PHD finger protein 20 like-1; SET7 = histone-lysine N-methyltransferase SETD7)
The depletion of the histone H3 lysine4 demethylase Lsd1 (Kdm1a) restores the ability of Mll4 null embryonic stem cells to transition from naive to primed pluripotency.
The findings demonstrated that LSD1 serves as an epigenetic regulator linking glucocorticoid action to metabolic programming during myogenic differentiation.
Together, these data show that LSD1 is required for normal in vivo plasmablast formation, distinguish LSD1 as a transcriptional rheostat and epigenetic modifier of B cell differentiation, and identify LSD1 as a factor responsible for decommissioning naive B cells active enhancers
this study shows that LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis
diminished expression of PU.1 or genetic deletion of C/EBPalpha in MLL-AF9 cells generates resistance of these leukemias to LSD1 inhibition. These findings reveal that pharmacologic inhibition of LSD1 represents a unique path to overcome the differentiation block in AML for therapeutic benefit.
collaborative action between SRRM4 and FUBP1 is necessary for mini-exon splicing of the neurospecific LSD1+8a isoform.
identify Lsd1 inhibitors as promising therapeutic agents for Gfi1-driven medulloblastoma.
Prkca-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory.
LSD1 and JMJD2C disable oncogenic Ras- or Braf-induced senescence by enabling the expression of E2F target genes
CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARgamma and inhibit adipogenesis.
These results indicate that LSD1 activators or miRNA antagonists could serve as a therapeutic approach for life-threatening septic shock characterized by dysfunction of hematopoietic stem cells.
MiR-137-3p was upregulated in Bv-injured DRGNs. MiR-137-3p downregulation rescued Bv-induced DRGN apoptosis and neurite retraction. MiR-137-3p and its downstream target LSD1 are inversely associated to regulate anesthetics-induced neurotoxicity in DRGN.
contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus replication by demethylating and activating IFITM3 which is a host restriction factor for many RNA viruses
Data (including data from studies in transgenic/knockout mice) suggest that Kdm1a-mediated attenuation of Srebf1 transcriptional activities functions as underlying mechanism for suppression of de novo lipogenesis by oxidative stress in white adipose tissue. [Kdm1a = lysine (K)-specific demethylase-1A; Srebf1 = sterol-regulatory element-binding transcription factor-1]
This study demonstrated that LSD1 expression during Olfactory Epithelium neuronal maturation.
LSD1 having a role in silencing additional odorant receptor (OR) alleles, as opposed to being required for the activation of OR alleles, within theolfactory-placode-derived cell line cellular context
results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2-mediated neuronal differentiation in the inner ear
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells into myocytes while preventing brown adipocyte differentiation of satellite cells via repressing expression of the novel pro-adipogenic transcription factor Glis1.
LSD1 is continuously required to prevent neurodegeneration. Loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex.
LSD1 consolidates into a single dominant compartment at the edges of chromocenters within nuclei of early post-mitotic cells of the mouse olfactory epithelium. LSD1 complexes with CoREST in early G1 of an immortalized olfactory cell line.
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, amine oxidase (flavin containing) domain 2
, flavin-containing amine oxidase domain-containing protein 2
, lysine (K)-specific demethylase 1
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3
, lysine (K)-specific demethylase 1A