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Human Monoclonal KDM1A Primary Antibody für ChIP, ELISA - ABIN151289
Lim, Janzer, Becker, Zimmer, Schüle, Buettner, Kirfel: Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. in Carcinogenesis 2010
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Human Polyclonal KDM1A Primary Antibody für ELISA, WB - ABIN1002761
Shi, Lan, Matson, Mulligan, Whetstine, Cole, Casero, Shi: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. in Cell 2004
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Human Polyclonal KDM1A Primary Antibody für IHC, ELISA - ABIN1002762
Kouzarides: Histone methylation in transcriptional control. in Current opinion in genetics & development 2002
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Human Polyclonal KDM1A Primary Antibody für IF, IHC (p) - ABIN388023
Forneris, Binda, Vanoni, Mattevi, Battaglioli: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. in FEBS letters 2005
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Human Monoclonal KDM1A Primary Antibody für IHC, ELISA - ABIN969264
Shi, Matson, Lan, Iwase, Baba, Shi: Regulation of LSD1 histone demethylase activity by its associated factors. in Molecular cell 2005
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Human Monoclonal KDM1A Primary Antibody für IF, IHC (p) - ABIN564989
Chen, Obara, Ishida, Suzuki, Yoshizato: Characterization of histone lysine-specific demethylase in relation to thyroid hormone-regulated anuran metamorphosis. in Development, growth & differentiation 2007
Human Polyclonal KDM1A Primary Antibody für ChIP, WB - ABIN5563974
Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. in PLoS genetics 2013
Human Monoclonal KDM1A Primary Antibody für IHC, ELISA - ABIN966497
Metzger, Wissmann, Yin, Müller, Schneider, Peters, Günther, Buettner, Schüle: LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. in Nature 2005
Human Polyclonal KDM1A Primary Antibody für ICC, IF - ABIN151968
Su, Ying, Chiu, Lin, Chen, Lin: Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. in Molecular and cellular biology 2009
Study showed that repressed HBV cccDNA chromatin state is activated by LSD1 by demethylating H3K9. Also, LSD1 was shown to be recruited to viral promoters in an HBx dependent manner.
LSD1 knockdown has a broad effect on histone lysine methylation.
analysis of a novel cellular stress response mechanism in cancer cells and a key role of LSD1/SIRT1/KU70 dynamic interaction in regulating DNA repair and mutation acquisition
Patients with mutations 6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1 (zeige ASXL1 Antikörper), TET2 (zeige TET2 Antikörper), TET3 (zeige TET3 Antikörper), KDM1A and MSH6 (zeige MSH6 Antikörper) were found in 25% of patients. TET2 (zeige TET2 Antikörper) or TET3 (zeige TET3 Antikörper), AKT1 (zeige AKT1 Antikörper) and RUNX1 (zeige RUNX1 Antikörper) were mutated in one patient each. ASXL1 (zeige ASXL1 Antikörper) was mutated within exon 12 in three cases
Study demonstrated that LSD1 in cooperation with MYCN controls cell migration and invasiveness of neuroblastoma cells through transcription regulation of the metastatic suppressor NDRG1.
Results show that LSD1 could directly bind to the promoter of P21 (zeige CDKN1A Antikörper), inducing H3K4me2 demethylation.
The autophagy induced by 2-PCPA requires LC3 (zeige MAP1LC3A Antikörper)-II processing machinery..2-PCPA treatment induces the change of global gene expression program, including a series of autophagy-related genes, such as SQSTM1/p62 (zeige SQSTM1 Antikörper). Taken together, our data indicate that KDM1A/LSD1 inhibitors induce autophagy through affecting the expression of autophagy-related genes and in a BECN1 (zeige BECN1 Antikörper)-independent manner
LSD1 is specifically mislocalized to pathological protein aggregates in the Alzheimer's disease and frontotemporal dementia patients brain.
these results demonstrate crosstalk between the lysine demethylase (zeige MBD2 Antikörper) KDM1A and the DNA methyltransferase (zeige DNMT1 Antikörper) DNMT1 (zeige DNMT1 Antikörper), which could be involved in carcinogenesis independently of its role in DNA methylation (zeige HELLS Antikörper)
LSD1 inhibition with HCI-2509 decreases the c-MYC (zeige MYC Antikörper) level in poorly differentiated prostate cancer cell lines.
results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2 (zeige PAX2 Antikörper)-mediated neuronal differentiation in the inner ear
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells into myocytes while preventing brown adipocyte differentiation of satellite cells via repressing expression of the novel pro-adipogenic transcription factor Glis1 (zeige GLIS1 Antikörper).
LSD1 is continuously required to prevent neurodegeneration. Loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex.
LSD1 consolidates into a single dominant compartment at the edges of chromocenters within nuclei of early post-mitotic cells of the mouse olfactory epithelium. LSD1 complexes with CoREST (zeige Rcor2 Antikörper) in early G1 of an immortalized olfactory cell line.
LSD1 is required for the timely expression of MyoD (zeige MYOD1 Antikörper) in limb buds.
Lsd1 is a key regulator of gene expression and metabolic function in brown adipose tissue.
The Demethylase (zeige MBD2 Antikörper) Activity of LSD1 Is Required for Brown Adipogenesis.
through interaction with Zfp516 (zeige ZNF516 Antikörper), LSD1 is recruited to UCP1 (zeige UCP1 Antikörper) and other brown adipose tissue-enriched genes.
Study propose that KDM1A is a key regulator of spermatogenesis and germ cell maintenance in the mouse.
This study demonstrates that the FGF19 (zeige FGF19 Antikörper)-SHP (zeige LAMC1 Antikörper)-LSD1 axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 (zeige ETV2 Antikörper) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase (zeige MBD2 Antikörper) activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, amine oxidase (flavin containing) domain 2
, flavin-containing amine oxidase domain-containing protein 2
, lysine (K)-specific demethylase 1
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3
, lysine (K)-specific demethylase 1A