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Study identified a novel tumor suppressive gene, KCNMA1, which is frequently inactivated in gastric cancer because of promoter methylation. KCNMA1 exerts a tumor suppressive function by regulating the PTK2 (zeige PTK2 Proteine) expression to activate the PI3K (zeige PIK3CA Proteine)-AKT (zeige AKT1 Proteine) pathway.
High BKCA expression is associated with breast cancer.
BKCa has a role in promoting growth and metastasis of prostate cancer through facilitating the coupling between alphavbeta3 integrin and FAK (zeige PTK2 Proteine)
Heme-independent activation of the CFTR (zeige CFTR Proteine) channel and the Slo1 BKCa channel by carbon monoxide (CO) may represent two different modes of gating regulation of ion channels by CO. In the case of CFTR (zeige CFTR Proteine), Fe3+ is bound to the R-ICL3 interface.15,16 This interfacial Fe3+ site is formed by traditional coordination ligands such as H950 and H954 from ICL3 and C832 and D836 from the R domain.[Review]
High BK channel is associated with glioblastoma.
Oxidant signaling underlies PKGIalpha modulation of Ca2 (zeige CA2 Proteine)+ sparks and BKCa in myogenically active arterioles
These data outline a new signaling mechanism by which KCa1.1 regulates beta1-integrin function and therefore invasiveness of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs).
These results provide further insights into the mechanism of modulation of the different N-terminal regions of the BKCa channel by beta-subunits.
Implicating both KCa1.1 and KCa3.1 (zeige KCNN4 Proteine) channels.
These results identify KCa1.1 channels as crucial regulators of skeletal myogenesis.
High cholesterol can reduce the protein expression of BK channel beta1 subunit in rabbit Oddi's sphincter (SO) cells which suggests high cholesterol can affect the function of BKca channel [BK channel beta1 subunit]
Aldosterone does not contribute to the regulation of BK channel expression/activity in response to dietary K(+) loading.
Slo1 channels in the lysosome are required for refilling lysosomal Ca(2 (zeige CA2 Proteine)+) stores.
Dynamic coupling between TRPV4 (zeige TRPV4 Proteine) and Ca(2 (zeige CA2 Proteine)+)-activated SK1 (zeige SPHK1 Proteine)/3 and IK1 (zeige KCNN4 Proteine) K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells.
The differential regulation of ROMK (zeige KCNJ1 Proteine), large-conductance Ca(2 (zeige CA2 Proteine)+)-activated K(+) (BK) channel, BK-alpha and NKCC2 (zeige SLC12A1 Proteine) between female and male mice, at least, were partly mediated via WNK1 (zeige WNK1 Proteine) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.
KCNMA1 contributes to the regulation of insulin (zeige INS Proteine) signalling in mature adipocytes
Results showed that BK-knockout osteoblasts displayed low proliferation and impaired mineralization ability providing further evidence that BK channel is critical for osteoblast function.
GSK3b may up-regulate BK channels, an effect disrupted by lithium or additional expression of AKT (zeige AKT1 Proteine) and possibly participating in the regulation of cell volume and excitability.
Data, including data from studies in knockout mice, suggest that association/disassociation of subunits Kcnma1 and Kcnab1 (zeige KCNAB1 Proteine) of the BK channel (large-conductance calcium-activated potassium channel (zeige KCNAB2 Proteine)) is involved in function of coronary artery smooth muscle cells and their dysfunction during ischemia/reperfusion-induced myocardial injury in diabetes.
This study demonstrated that The interaction of MaxiK channel with GAT3 (zeige SLC6A13 Proteine) opens the possibility of a role of MaxiK channel in GABA homeostasis and signaling.
the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC (zeige SCNN1A Proteine)-mediated sodium reabsorption
Data suggest that the ion channels CaV1.3 (zeige CACNA1D Proteine), bestrophin-1 (zeige BEST1 Proteine) and maxiK were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE (zeige RPE Proteine)).
analysis of SLO3 (zeige KCNU1 Proteine) K+ channels shows evolutionary divergence for an RCK1 region of critical function
A neural-specific splice-variant exon of Slo serves as a gain-of-function module and allows physiologically relevant levels of membrane potential and intracellular calcium to activate the resultant channel effectively during Xenopus embryogenesis.
Porcine K2P3.1 (zeige KCNK3 Proteine) channels exhibit atrial expression and functional properties similar to their human orthologs, supporting a general role as antiarrhythmic drug targets.
Inositol trisphosphate is an activator of BKCA channels in porcine coronary smooth muscle cells and exerts a coronary artery-relaxing effect.
Testerone-induced relaxation of endothelium-denuded coronary arteries is mediated, at least in part, by enhanced NO production, leading to cGMP synthesis and PKG (zeige PRKG1 Proteine) activation, which, in turn, opens BK(Ca) channels.
Removal of element 6b from the endogenous slo (zeige SLO Proteine) gene affected the production of functional ethanol tolerance in an ethanol-vapor recovery from sedation assay.
SLO2 (zeige KCNT1 Proteine) Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels
Slo (zeige SLO Proteine) mutant larvae exhibit alterations in synapse morphology, active zone size and neurotransmission that are similar to dysc mutants.
Results show using the Drosophila model organism, we demonstrate a central role for the BK-type Ca(2 (zeige CA2 Proteine)+) -activated K(+) channel (zeige KCNC4 Proteine) gene slo (zeige SLO Proteine) in the production of alcohol withdrawal seizures
Here we examined the action of docosahexaenoic acid on the Slo1 channel without any auxiliary subunit and sought to elucidate the biophysical mechanism and the molecular determinants of the DHA sensitivity.
Our work identifies a Drosophila homolog of a deaf-blindness gene as a new component of the circadian output pathway,termed DYSC(dyschronic) whish expressed in major neuronal tracts and regulates expression of SLOWPOKE (SLO (zeige SLO Proteine))
Results propose that modulation of SLO (zeige SLO Proteine) by SLOB regulates neurotransmission in mNSCs, influencing downstream insulin (zeige INS Proteine) pathway signaling and metabolism.
monomeric D14-3-3zeta (zeige YWHAZ Proteine) is capable of modulating dSlo channel activity in this regulatory complex.
synaptic strength and synaptic strength at neuromuscular junctions along the dorsal-ventral differentials at physiological Ca(2+) levels were not significantly altered in slowpoke (slo) and Shaker (Sh) mutants
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
BK channel alpha subunit
, BKCA alpha subunit
, calcium-activated potassium channel subunit alpha-1
, calcium-activated potassium channel, subfamily M subunit alpha-1
, maxi-K channel HSLO
, slo homolog
, slowpoke homolog
, stretch-activated Kca channel
, calcium-activated potassium channel subunit alpha 1
, BK channel
, BKCA alpha
, large conductance calcium-activated potassium channel alpha subunit
, maxi K channel
, calcium-activated potassium channel alpha subunit
, MaxiK calcium-activated potassium channel
, calcium activated potassium channel protein
, large conductance calcium-activated potassium (BK) channel alpha subunit a
, potassium large conductance calcium-activated channel, subfamily M, alpha member 1
, large conductance calcium-activated potassium channel subfamily M alpha member 1
, pulmonary calcium activated potassium channel
, calcium-activated potassium channel subunit alpha-1-like
, large calcium-activated potassium channel alpha member 1
, CG10693 gene product from transcript CG10693-RS
, Maxi K channel