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anti-Human AXIN2 Antikörper:
anti-Mouse (Murine) AXIN2 Antikörper:
anti-Rat (Rattus) AXIN2 Antikörper:
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increased abundance of Snail (zeige SNAI1 Antikörper) and Axin2 is highly correlated to malignant transformation of OL, making them novel biomarker(s) predicting oral cancer development
Review. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarian or lung cancer.
Consistent with bioinformatics predictions, SOX7 (zeige SOX7 Antikörper) was correlated positively with AXIN2 and negatively with beta-catenin (zeige CTNNB1 Antikörper), suggesting that SOX7 (zeige SOX7 Antikörper) and AXIN2 might play important roles as co-regulators through the Wnt (zeige WNT2 Antikörper)-beta-catenin (zeige CTNNB1 Antikörper) pathway in the breast tissue to affect the carcinogenesis process.
we performed an association study of AXIN2, BMP4 (zeige BMP4 Antikörper) and IRF6 (zeige IRF6 Antikörper) gene SNPs with Non-Syndromic Cleft Lip with or without Cleft Palate in an Iranian population and the findings proposed that BMP4 (zeige BMP4 Antikörper) rs17563 polymorphism is associated with reduced risk against Non-Syndromic Cleft Lip with or without Cleft Palate.
The results demonstrated miR (zeige MLXIP Antikörper)-3120-5p promotes stemness and invasiveness of colon cancer cells through direct targeting of Axin2.
Hepatic Axin2 expressing CD90 (zeige THY1 Antikörper)+ cells play a cancer stem cell-like role in the progression from liver cirrhosis to hepatocarcinoma.
role in the formation of degradasomes and degradation of beta-catenin (zeige CTNNB1 Antikörper) induced by the TNKSi G007-LK in colorectal cancer cells
AXIN2 overexpression is associated with Breast Cancer Invasion and Metastasis.
the study reveals a strong association of SNPs in the Axin2 gene with lung cancer risk in North Indians.
Genetic variant in AXIN2 gene is associated with gallbladder cancer.
beta-catenin1 cannot revert the ich (zeige ACE Antikörper) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (zeige PITX2 Antikörper) domain function.
Study provides evidence that Axin2-expressing cells execute regeneration after skeletal injury.
identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling.
increased mesenchymal Wnt (zeige WNT2 Antikörper) signaling inhibits the sequential formation of teeth, and suggest that Axin2/Runx2 (zeige RUNX2 Antikörper) antagonistic interactions modulate the level of mesenchymal Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling, underlying the contrasting dental phenotypes caused by human AXIN2 and RUNX2 (zeige RUNX2 Antikörper) mutations
we found that ESC-derived tissues at day 7 grown in Glasgow Minimum Expression Media (GMEM (zeige TNC Antikörper)) containing knockout serum replacement (KSR (zeige KSR1 Antikörper)) exhibited higher levels of expression of axin2, a Wnt (zeige WNT2 Antikörper) target gene, than those grown in chemically defined medium
Barx2 (zeige BARX2 Antikörper) and Pax7 (zeige PAX7 Antikörper) regulate the canonical Wnt (zeige WNT2 Antikörper) target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt (zeige WNT2 Antikörper) signals.
Axin2 limits Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease.
Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway.
The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis
Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
, axin-like protein
, axis inhibition protein 2
, axin 2 (conductin, axil)
, axin-related protein
, axin 2
, Axin-related protein