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anti-Human AXIN2 Antikörper:
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Human Polyclonal AXIN2 Primary Antibody für WB - ABIN6137382
Chen, Zheng, Liu, Shi, Qi: Periostin activates pathways involved in epithelial-mesenchymal transition in adamantinomatous craniopharyngioma. in Journal of the neurological sciences 2016
By domain swapping between axin and conductin the authors here identify an aggregation site in the conductin RGS domain which prevents conductin polymerization. Induction of conductin polymerization by point mutations of this aggregon results in enhanced inhibition of Wnt/beta-catenin signaling.
This family contributes to our understanding of the varying phenotypes of AXIN2 mutation carriers and adds support to our hypothesis that truncating mutations in exon 7 of AXIN2 causes syndromic oligodontia and colorectal adenomatous polyposis/CRC compared with mutations in other regions of the AXIN2 gene.
This clinical report adds value to the literature that AXIN2 gene mutations could be a potential cause in human calvarial malformations, especially for the sagittal synostosis.
miR-221-3p and AXIN2 regulate the proliferation of pulmonary artery smooth muscle cells in pulmonary arterial hypertension.
A1CF-Axin2 signal axis regulates Wilms tumor-derived cells' apoptosis and migration through Axin2.
The polymorphisms rs11079571 and rs3923087, but not rs3923086, were associated with an increased risk of Breast Cancer (BC). The minor allele containing genotypes of polymorphism rs3923087 were positively associated with lymph node metastases. A haplotype analysis demonstrated that the ATA haplotype was correlated with an increased risk of BC.
Axin2 rs2240308 may modify cancer susceptibility in an ethnicity- and/or type-specific manner [meta-analysis]
Novel mutations of AXIN2 identified in a Chinese Congenital Heart Disease Cohort.
We also identified one variant in the AXIN2 gene as being a putative risk factor for tooth agenesis.
increased abundance of Snail and Axin2 is highly correlated to malignant transformation of OL, making them novel biomarker(s) predicting oral cancer development
Review. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarian or lung cancer.
Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 and negatively with beta-catenin, suggesting that SOX7 and AXIN2 might play important roles as co-regulators through the Wnt-beta-catenin pathway in the breast tissue to affect the carcinogenesis process.
we performed an association study of AXIN2, BMP4 and IRF6 gene SNPs with Non-Syndromic Cleft Lip with or without Cleft Palate in an Iranian population and the findings proposed that BMP4 rs17563 polymorphism is associated with reduced risk against Non-Syndromic Cleft Lip with or without Cleft Palate.
The results demonstrated miR-3120-5p promotes stemness and invasiveness of colon cancer cells through direct targeting of Axin2.
Hepatic Axin2 expressing CD90+ cells play a cancer stem cell-like role in the progression from liver cirrhosis to hepatocarcinoma.
role in the formation of degradasomes and degradation of beta-catenin induced by the TNKSi G007-LK in colorectal cancer cells
AXIN2 overexpression is associated with Breast Cancer Invasion and Metastasis.
the study reveals a strong association of SNPs in the Axin2 gene with lung cancer risk in North Indians.
The genotype distribution of the rs1133683 polymorphism C> T showed a statistical difference between the two study groups ( p = 0.0019). individuals with either the C/T or T/T genotype have a decreased risk for colorectal cancer. For the rs2240308 polymorphism C > T, the OR analysis showed a significantly increased risk for carriers of the T/T genotype.
Genetic variant in AXIN2 gene is associated with gallbladder cancer.
beta-catenin1 cannot revert the ich phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS domain function.
Study provides evidence that Axin2-expressing cells execute regeneration after skeletal injury.
identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling.
increased mesenchymal Wnt signaling inhibits the sequential formation of teeth, and suggest that Axin2/Runx2 antagonistic interactions modulate the level of mesenchymal Wnt/beta-catenin signaling, underlying the contrasting dental phenotypes caused by human AXIN2 and RUNX2 mutations
we found that ESC-derived tissues at day 7 grown in Glasgow Minimum Expression Media (GMEM) containing knockout serum replacement (KSR) exhibited higher levels of expression of axin2, a Wnt target gene, than those grown in chemically defined medium
Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals.
Axin2 limits Wnt/beta-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/beta-catenin signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease.
Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt/beta-catenin pathway.
The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis
Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/beta-catenin signaling.
Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation.
Axin1 and Axin2 do not have equivalent functions in satellite cells, but are both involved in repression of Wnt/beta-catenin signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
These data demonstrate a dominant role for Runx2 in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation.
implants lacking primary stability undergo osseointegration, provided Wnt signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt signalling is elevated at the time of implant placement.
Axin2(-/-) PF-sutures lack physiological endochondral ossification
Axin2(+) cells can give rise to spatially and functionally restricted populations of adult neural stem cells in the subventricular zone.
Axin2-positive tympanic border cells are Wnt responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea.
Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice
Data show that expression of Brachyury targets Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos.
Lgr5 and Axin2 differential expression among cell populations highlights the dynamic but complex distribution of Wnt-activated cells in and around the embryonic and postnatal cochlea.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
, axin-like protein
, axis inhibition protein 2
, axin 2 (conductin, axil)
, axin-related protein
, axin 2
, Axin-related protein