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Two genes, TNR (and TNK2 (zeige TNK2 Proteine)), were found to have genetic variations linked to familial Parkinson's Disease.
TnC (zeige TNC Proteine) and TnR play important roles in nervous and immune systems. [Review]
citation presents comparison with human gene.
results show that tenascin-R expression is tightly regulated in a spatiotemporal manner during brain development, especially cortical plate formation; its pattern of expression suggests a role for tenascin-R in corticogenesis
KIAA0510, the 3'-untranslated region of the tenascin-R gene, and tenascin-R are overexpressed in pilocytic astrocytomas
The researchers found evidence that the tenascin R gene is a potential susceptiblity or marker gene for IgA nephropathy.
Tenascin R is expressed and glycosylated in neurons
An extracellular matrix molecule TNR and its associated carbohydrate human natural killer cell glycan (HNK-1 (zeige B3GAT1 Proteine)) provide conditions beneficial for induction of long-term potentiation in the hippocampus.
The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack tenascin-C (zeige TNC Proteine), the informational content stored by synaptic plasticity is not the same.
Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan (zeige ACAN Proteine).
Aggrecan (zeige ACAN Proteine), link protein (zeige HAPLN1 Proteine) and TN-R were identified to be essential for the neuroprotective properties of the perineuronal net.
These findings indicate the importance of TNR in the regulation of hippocampal neurogenesis and suggest that TNR acts through distinct direct and indirect mechanisms during development and in the adult.
TNR is expressed in a subset of astrocytes and contributes to glutamate (zeige GRIN1 Proteine) homeostasis by regulating astrocytic GLAST (zeige SLC1A3 Proteine) expression.
Our results indicate that TNR modulates adult but not developmental neurogenesis in the olfactory bulb
This study provided evidence that the tenascin-R modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.
Ablation of TNR modifies the extracellular matrix and leads to reorganization of the dentate gyrus with enhanced GABAergic innervation and altered plasticity, promoting working memory and reversal learning.
TN-R appears to play an important role in the regulation of the number and architecture of perisomatic inhibitory synapses onto hippocampal pyramidal cells.
the impact of TN-R deficiency on the living animal
Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion\; MIM 187380), TNX (TNXB\; MIM 600985), and TNR (Erickson, 1993
, neural recognition molecule J1-160/180
, Tenascin-R (Restrictin janusin J1-160/180)
, Tenascin-R (Restrictin, janusin, J1-160/180)
, tenascin R (restrictin, janusin)