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Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers
The RND2 mRNA levels increased significantly after gestation in myometria.
Rnd2 regulates neurite outgrowth by functioning as the RhoA (zeige RHOA Proteine) activator through Pragmin, in contrast to Rnd1 (zeige RND1 Proteine) and Rnd3 (zeige RND3 Proteine) inhibiting RhoA (zeige RHOA Proteine) signaling
RP58 (zeige ZNF238 Proteine) represses transcription of Rnd2 via binding to a 3'-regulatory enhancer in a sequence-specific fashion. Using reporter assays, we found that RP58 (zeige ZNF238 Proteine) repression of Rnd2 is competed by proneural basic helix-loop-helix transcriptional activators.
Data demonstrate that COUP-TFI (zeige NR2F1 Proteine) modulates late-born neuron migration and favours proper differentiation of callosal projection neurons by finely regulating Rnd2 expression levels.
results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 (zeige NEUROG2 Proteine) function in the promotion of migration
Rnd2 bound to Plexin-D1 in cortical neurons, and Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical neurons required Rnd2 and down-regulation of R-Ras activity.
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.
rho-related GTP-binding protein RhoN
, ras homolog gene family, member N
, GTP-binding protein Rho7
, rho-related GTP-binding protein Rho7
, aplysia ras-related homolog N (RhoN)
, ras homolog N (RhoN)