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anti-Human Osteopontin Antikörper:
anti-Mouse (Murine) Osteopontin Antikörper:
anti-Rat (Rattus) Osteopontin Antikörper:
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Human Monoclonal Osteopontin Primary Antibody für ICC, IF - ABIN259958
Kon, Yokosaki, Maeda, Segawa, Horikoshi, Tsukagoshi, Rashid, Morimoto, Inobe, Shijubo, Chambers, Uede: Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. in Journal of cellular biochemistry 2002
Show all 16 Pubmed References
Dog (Canine) Polyclonal Osteopontin Primary Antibody für IHC (p), IP - ABIN153090
Kim, Shin: Immunohistochemical study of osteopontin in boar testis. in Journal of veterinary science 2007
Show all 4 Pubmed References
Human Polyclonal Osteopontin Primary Antibody für ELISA, ICC - ABIN250537
Alonso, Tracey, Ortiz, Pérez-Gómez, Palacios, Pollán, Linares, Serrano, Sáez-Castillo, Sánchez, Pajares, Sánchez-Aguilera, Artiga, Piris, Rodríguez-Peralto: A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. in Cancer research 2007
Show all 4 Pubmed References
Human Polyclonal Osteopontin Primary Antibody für IHC (fp), IHC - ABIN105163
Ashkar, Weber, Panoutsakopoulou, Sanchirico, Jansson, Zawaideh, Rittling, Denhardt, Glimcher, Cantor: Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. in Science (New York, N.Y.) 2000
Show all 18 Pubmed References
Mouse (Murine) Polyclonal Osteopontin Primary Antibody für IF (cc), IF (p) - ABIN723800
Zhang, Men, Fu, Shan, Ye, Wu, Tao, Liu, Jiang: Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones. in Cell and tissue research 2012
Show all 3 Pubmed References
Human Monoclonal Osteopontin Primary Antibody für ICC, IHC - ABIN1098149
Liersch, Gerss, Schliemann, Bayer, Schwöppe, Biermann, Appelmann, Kessler, Löwenberg, Büchner, Hiddemann, Müller-Tidow, Berdel, Mesters: Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients. in Blood 2012
Show all 2 Pubmed References
Dog (Canine) Polyclonal Osteopontin Primary Antibody für EIA, IHC (p) - ABIN118005
Yamasaki, Nair, Bhattacharya, Yamamoto, Kurazono, Takeda: Cryptic appearance of a new clone of Vibrio cholerae serogroup 01 biotype El Tor in Calcutta, India. in Microbiology and immunology 1997
Show all 14 Pubmed References
Human Polyclonal Osteopontin Primary Antibody für IF (p), IHC (p) - ABIN723695
Liu, Zhang, Wang, Zhang, Chen, Wu: A Strontium-Modified Titanium Surface Produced by a New Method and Its Biocompatibility In Vitro. in PLoS ONE 2015
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Mouse (Murine) Polyclonal Osteopontin Primary Antibody für IHC (p), WB - ABIN3042687
Zhou, Jin, Li, Zhao, Zhang, Wang, Li, Zhang, Xiang: Total flavonoids of Desmodium styracifolium attenuates the formation of hydroxy-L-proline-induced calcium oxalate urolithiasis in rats. in Urolithiasis 2017
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Human Polyclonal Osteopontin Primary Antibody für IHC (fp), IHC - ABIN1043686
Aita, Barrera, Reniero, Lopez, Biglione, Weisburd, Rajmil, Largacha, Ritacco: Hospital transmission of multidrug-resistant Mycobacterium tuberculosis in Rosario, Argentina. in Medicina 1996
Show all 2 Pubmed References
OPN play a role in pathogenesis of neurodegenerative diseases or in neuroprotection by regulating the activation and function of microglia.
osteopontin has a role in DNA repair and impact on human glioblastoma radiosensitivity
SPP1 promoted the metastasis of CRC (zeige CALR Antikörper).
Results show that osteopontin is positively associated with hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) metastasis, and that OPN can activate CCR1 expression through the PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper)/HIF-1a (zeige HIF1A Antikörper) signaling pathway to promote HCC (zeige FAM126A Antikörper) progression and metastasis.
This review presents the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. [review]
Strong correlations between the expression of type I, II, IV collagen and osteopontin and the clinical stage of tympanosclerosis indicate the involvement of these proteins in excessive fibrosis and pathological remodeling of the tympanic membrane.
result of this study confirms that increased levels of OPN exist in CSF (zeige CSF2 Antikörper) and peripheral blood of MS patients and strengthens the evidence regarding the clinical utility of OPN as a promising and validated biomarker for MS
OPN overexpression was correlated with poor overall survival and clinical features reflecting high aggressiveness in patients with gastric cancer.
ITGbeta3 and CD44 (zeige CD44 Antikörper) expression levels determine whether OPN-a inhibits or enhances growth in lung cancer cells.
Study identified that miR (zeige MLXIP Antikörper)-127-5p targets the 3' UTR (zeige UTS2R Antikörper) of osteoarthritis (OA) mRNA to down-regulate the expression of OPN. In OA, the down-expressed miR (zeige MLXIP Antikörper)-127-5p allows the expression of OPN, which mediates the establishment and development of OA.
The findings reveal that hepatic OPN contributes to cholesterol gallstone formation by regulating biliary metabolism and might be developed as a therapeutic target for gallstone treatments.
Endogenous OPN emerges as a key player in the pathogenesis of chronic Chagas heart disease, through the upregulation of myocardial CCL5 (zeige CCL5 Antikörper)/MMP-2 (zeige MMP2 Antikörper) expression and activities resulting in pro-inflammatory and pro-hypertrophic events, cardiac remodeling and interstitial fibrosis.
In this study, the effect of deficiency of OPN on intestinal tumor development in Apc (zeige APC Antikörper)-deficient Min mice was investigated.At 16 weeks of age, the number of small intestinal polyps in Min/OPN(+/-) and Min/OPN(-/-) mice was lower than that of Min/OPN(+/+) mice. Colorectal tumor incidences and multiplicities in Min/OPN(+/-) and Min/OPN(-/-) mice were significantly lower than those in Min/OPN(+/+) mice
Osteopontin RNA aptamer is a novel and effective approach for preventing cardiac hypertrophy and fibrosis, improving cardiac function, and reversing pressure overload-induced heart failure.
OPN deficiency reduced the incidence of chemically induced HCC (zeige FAM126A Antikörper) by suppressing EGFR (zeige EGFR Antikörper)-mediated anti-apoptotic signaling.
In experimental autoimmune encephalomyelitis treated with interferon-beta (zeige IFNB1 Antikörper), OPN was significantly decreased in splenocyte supernatants. Neutralizing OPN antibodies offset the inhibitory effect of IFN-beta (zeige IFNB1 Antikörper) on Th17 cells. IFN-beta (zeige IFNB1 Antikörper) influenced the acetylation of the Opn gene promoter. IFN-beta (zeige IFNB1 Antikörper) plays a role in Th17 differentiation partly through the inhibition of OPN.
Osteopontin plays a key role in vascular smooth muscle cell via signaling pathways involving AP-1 (zeige JUN Antikörper) and C/EBP beta (zeige CEBPB Antikörper), leading to increases in vascular smooth muscle cell proliferation and subsequent vascular remodeling.
we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 (zeige FN1 Antikörper) and SPP1 as the central mediators in these processes
Data show that, together, osteocalcin (OC (zeige BGLAP Antikörper)) and osteopontin (OPN) play important roles in determining bone size, shape, and strength.
Results show that BSP (zeige KLK6 Antikörper) and OPN are present in the mineralized tissues of fibrocartilaginous enthuses.
This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.
Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.
Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.
Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.
OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs (zeige PTMS Antikörper)) compared to human Escherichia-coli-derived recombinant OPN without PTMs (zeige PTMS Antikörper).
topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (zeige CRISP1 Antikörper)
the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6
These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.
The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.
Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.
results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene
Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.
A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608
The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (zeige CEBPB Antikörper) binding site and this binding site is negatively affected by the mutant G allele.
in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production
osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.
Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.
Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.
The SPP1 was principally expressed in motor neurons in lamina IX of the macaque spinal cord.The expression level varied among different spinal segments and correlated positively with neuron size.
results demonstrate that SPP1 is expressed in corticospinal tract neurons in M1 and several other sensorimotor cortices
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
, early T-lymphocyte activation 1
, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
, urinary stone protein
, 44 kDa bone phosphoprotein
, bone sialoprotein 1
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein
, Sialoprotein (osteopontin)
, bone sialoprotein I
, spp1 protein
, secreted phosphoprotein-1
, LOW QUALITY PROTEIN: osteopontin
, Bone sialoprotein 1