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Human Netrin 1 Protein expressed in HEK-293 Cells - ABIN1344145
Rama, Goldschneider, Corset, Lambert, Pays, Mehlen: Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth. in The Journal of biological chemistry 2012
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Human Netrin 1 Protein expressed in HEK-293 Cells - ABIN1344382
Ozmadenci, Féraud, Markossian, Kress, Ducarouge, Gibert, Ge, Durand, Gadot, Plateroti, Bennaceur-Griscelli, Scoazec, Gil, Deng, Bernet, Mehlen, Lavial: Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance. in Nature communications 2015
our data suggest that netrin-1 contributes to the migration of the neural folds towards the midline
Partial knock down of netrin-1 confirms that this chemoattractive ligand of neogenin (zeige NEO1 Proteine) acts in the same early forming dorsoventral brain pathway.
Studies identify netrin-1 as an active participant in retinal ganglion cell axon presynaptic differentiation, not only as they navigate along their pathway but also at their target.
Results demonstrate that NTN1 is an important regulator of stemness and motility of glioblastoma cells. Furthermore, it deciphers a novel mechanism where NTN1 activates Notch (zeige NOTCH1 Proteine) signaling and subsequent stemness in invasive glioblastoma cells.
Three mutations in exon 7 of NTN1 in 2 unrelated families and 1 sporadic case with isolated congenital mirror movements (CMM), a disorder characterized by involuntary movements of one hand that mirror intentional movements of the opposite hand.
Netrin-1 acts as a non-canonical angiogenic factor (zeige VEGFA Proteine) produced by human Wharton's jelly mesenchymal stem cells.
Our study has shown an increase in netrin-1 expression that could be linked with macrophage infiltration and polarization in the epicardial adipose tissue of patients with coronary artery disease
netrin-1 degradation products are capable of modulating vascular permeability in diabetic retinopathy
Enhanced detection of netrin-1-expressing CD14(low) cells in patients with systemic sclerosis-related interstitial lung disease was observed, and antibody-mediated netrin-1 neutralization attenuated detection of fibrocytes in all settings.
we review the Netrin-1 mediated regulation of cancer, its potential use as a biomarker, and the targeting of the Netrin-1 pathway to treat cancers
Our observations revealed that SOX6 is a tumor suppressor in ovarian cancer cells, and SOX6 exerts an inhibitory effect on the proliferation, invasion, and tumor cell-induced angiogenesis of ovarian cancer cells, whereas nerin-1 plays an opposite role and its expression is inversely correlated with SOX6.
NTN1 rs9788972 is identified as a risk locus for nonsyndromic orofacial clefts susceptibility in a northern Chinese population; SNPs in PAX7 (zeige PAX7 Proteine) were not associated with any increased risk
that netrin-1 may function as a positive regulator of hypoxia-triggered malignant behavior in prostate cancer by activating the Yes-associated protein signaling
Data indicate that the formation of the hypothalamic NPY (zeige NPY Proteine) neural network is regulated at least partly by Netrin-1 signalling during normal in utero brain development in the mouse.
Our findings suggest that netrin-1 can suppress the growth of PDAC and provide a mechanistic insight into this suppression.
Diabetes decreases aortic levels of netrin-1. However, overexpression of netrin-1 attenuates diabetes-induced VED and limits the reduction of NO levels, while increasing expression of p-ERK1/2, and suppressing oxidative stress and inflammatory and apoptotic processes
Ntn1 may play divergent cellular roles despite its conserved expression during canal morphogenesis in chicken and mouse.
Blockade of Netrin-1/Unc5b (zeige UNC5B Proteine) by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis
Results suggest that Netrin1/DCC (zeige DCC Proteine) signaling induce neuronal migration in the dorsal spinal cord.
results show that the classical view that attraction of commissural axons is mediated by a gradient of floor-plate-derived netrin-1 is inaccurate and that netrin-1 primarily acts locally by promoting growth cone adhesion.
Here, we report that dissociation of UNC5C (zeige Unc5c Proteine) and polymerized TUBB3 (zeige TUBB3 Proteine), the highly dynamic beta-tubulin (zeige TUBB Proteine) isoform in neurons, is essential for netrin-1/UNC5C (zeige Unc5c Proteine)-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs (zeige NEU2 Proteine) by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 (zeige TUBB3 Proteine) mutations.
Netrin-1(+/-) mice were protected against bleomycin-induced lung fibrosis and fibrocyte accumulation.
Treatment with endogenous anti-inflammatory protein netrin-1 reduces pulmonary inflammation during the initial stages of acute lung injury.
Netrin-1 could be important for follicular function in the swine.
findings show that the netrin-1 and p53RDL1 (zeige UNC5B Proteine) system may regulate the induction of apoptosis in porcine granulosa cells
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined\; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.
, epididymis tissue protein Li 131P
, netrin 1, mouse, homolog of