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anti-Mouse (Murine) CXCR4 Antikörper:
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Human Monoclonal CXCR4 Primary Antibody für CyTOF, FACS - ABIN4900744
Griffiths, Dolezal, Cao, Nilsson, See, Pfleger, Roche, Gorry, Pow, Viduka, Lim, Lu, Chang, Murray-Rust, Kvansakul, Perugini, Dogovski, Doerflinger, Zhang, Parisi, Casey, Nuttall, Foley: i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4. in The Journal of biological chemistry 2016
Show all 25 Pubmed References
Human Monoclonal CXCR4 Primary Antibody für CyTOF, FACS - ABIN4900745
Hansson, Olesen, Peterslund, Engberg, Kahn, Winzi, Klein, Maddox-Hyttel, Serup: A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. in Developmental biology 2009
Show all 21 Pubmed References
Human Monoclonal CXCR4 Primary Antibody für FACS - ABIN4898488
Peled, Abraham, Avivi, Rowe, Beider, Wald, Tiomkin, Ribakovsky, Riback, Ramati, Aviel, Galun, Shaw, Eizenberg, Hardan, Shimoni, Nagler: The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Show all 17 Pubmed References
Human Monoclonal CXCR4 Primary Antibody für FACS - ABIN4898487
Misao, Takemura, Arai, Ohno, Onogi, Takahashi, Minatoguchi, Fujiwara, Fujiwara: Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF. in Cardiovascular research 2006
Show all 17 Pubmed References
Human Polyclonal CXCR4 Primary Antibody für ICC, IF - ABIN261500
Hasegawa, McLeod, Prow, Merges, Grebe, Lutty: Vascular precursors in developing human retina. in Investigative ophthalmology & visual science 2008
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Mouse (Murine) Monoclonal CXCR4 Primary Antibody für CyTOF, FACS - ABIN4899088
Rider, Carmi, Guttman, Braiman, Cohen, Voronov, White, Dinarello, Apte: IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 15 Pubmed References
Human Monoclonal CXCR4 Primary Antibody für CyTOF, FACS - ABIN4900746
Albanesi, Scarponi, Pallotta, Daniele, Bosisio, Madonna, Fortugno, Gonzalvo-Feo, Franssen, Parmentier, De Pità, Girolomoni, Sozzani: Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. in The Journal of experimental medicine 2009
Show all 15 Pubmed References
Human Polyclonal CXCR4 Primary Antibody für ICC, IF - ABIN4301203
Kulbe, Hagemann, Szlosarek, Balkwill, Wilson: The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells. in Cancer research 2005
Show all 13 Pubmed References
Human Polyclonal CXCR4 Primary Antibody für FACS, IF (p) - ABIN730888
Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Show all 12 Pubmed References
Human Monoclonal CXCR4 Primary Antibody für FACS - ABIN2689042
Hesselgesser, Halks-Miller, DelVecchio, Peiper, Hoxie, Kolson, Taub, Horuk: CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. in Current biology : CB 1997
Show all 10 Pubmed References
bilateral lineup in the trunk before PGC migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor gene cxcr4b
Cardiac stem cells express CXCR4. Activation of c-kit (zeige KIT Antikörper) signalling by SCF (zeige KITLG Antikörper) promotes migration of CSCs with increased phosphorylation of CXCR4-serine 339, p38 mitogen-activated protein kinase (p38 MAPK (zeige MAPK14 Antikörper)) and extracellular regulated protein kinases 1/2 (ERK1/2).
nitration on Tyr7 under inflammatory conditions is a novel natural posttranslational regulatory mechanism of CXCL12 (zeige CXCL12 Antikörper) which may downregulate the CXCR4-mediated inflammatory and tumor-promoting activities of CXCL12 (zeige CXCL12 Antikörper)
Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1alpha in a manner critically dependent on signaling via the SDF-1alpha-CXCR4 axis.
The Function of SDF-1-CXCR4 Axis in SP Cells-Mediated Protective Role for Renal Ischemia/Reperfusion Injury by SHH/GLI1-ABCG2 Pathway
the pivotal role of CXCR4- and CXCR7 (zeige CXCR7 Antikörper)-inhibition in acute pulmonary inflammation, which depended on A2B (zeige ADORA2B Antikörper)-receptor signaling, is reported.
CXCR4 signaling is critical for perivascular invasion of GBM cells and radiation sensitivity.
The results provide the first evidence that upregulation of TGFb (zeige TGFB1 Antikörper)/Smad3 (zeige SMAD3 Antikörper) in injured arteries induces local smooth muscle cells CXCR4 expression and cell migration, and consequently intimal hyperplasia.
results characterize CXCR4 as an important pathway that modulates immune dysfunction and mortality following sepsis, which may hold promise as a target for future therapeutic intervention in septic patients
CXCL12 (zeige CXCL12 Antikörper)/CXCR4 signaling negatively modulates the bipotential state of Hemogenic endothelial cells independently of the hematopoietic fate.
Efficient plasma cell differentiation and trafficking require Cxcr4 desensitization.
The present study demonstrates for the first time that IL-3 (zeige IL-3 Antikörper) has an important role in enhancing the migration of human MSCs through regulation of the CXCR4/SDF-1alpha axis. These findings suggest a potential role of IL-3 (zeige IL-3 Antikörper) in improving the efficacy of MSCs in regenerative cell therapy.
Overexpression of CXCR4 facilitated tumor growth and angiogenesis in SGC7901 xenograft tumors, which was associated with increased levels of phospho-STAT3 (zeige STAT3 Antikörper). CXCR4 contributes to tumor angiogenesis in gastric cancer by inducing STAT3 (zeige STAT3 Antikörper)-dependent VEGF (zeige VEGFA Antikörper) expression.
The findings indicated that SDF-1alpha/CXCR4 signaling pathway might be associated with the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma.
Report weak-to-moderate CXCR4 immunoreactivity in majority of colorectal carcinoma resection samples, and no association with prognosis/survival.
Data show that the majority of binding site residues of CXC chemokine receptor 4 (CXCR4) form a continuous intramolecular signaling chain through the transmembrane helices.
this study shows that stem cell autocrine CXCL12 (zeige CXCL12 Antikörper)/CXCR4 stimulates invasion and metastasis of esophageal cancer
In FOXC2 (zeige FOXC2 Antikörper) knockdown cell lines, CXCR4, a downstream target of FOXC2 (zeige FOXC2 Antikörper), can restore osteosarcoma cell invasiveness and metastasis to the lung
Results has shown that CXCR4 was highly expressed in non-small cell lung cancer (NSCLC) tissues and metastatic lymph nodes. CXCR4 expression levels was significantly correlated with lymph node metastasis in NSCLC. Along with VEGF-C (zeige VEGFC Antikörper), CXCR4 might synergically promote lymphatic metastasis in lung cancer and might be a clinical predictor of lymph node metastasis in NSCLC patients.
In this review, the discovery of small molecule CXCR4 antagonists focused on the structures, activities, evolution and development of representative CXCR4 antagonists is comprehensively described. The central role of CXCR4 in diverse cellular signaling pathways and its involvement in several diseases progressions are discussed as well.
CXCR4 controls leukocyte mobilization after trauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (zeige CXCL12 Antikörper)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
reports transmural and perivascular expression patterns of chemokines CCL2 (zeige CCL2 Antikörper) and CXCL2 (zeige CXCL2 Antikörper) and of chemokine (zeige CCL1 Antikörper) receptors CCR2 (zeige CCR2 Antikörper), CCR5, and CXCR4 following coronary angioplasty
The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
There is a potential link between follicular SDF1 (zeige CXCL12 Antikörper)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
The combination of low expression of CXCR4 and high expression of IL-10 (zeige IL10 Antikörper) might be closely concerned with some bias for the production of PI calves.
The increased CXCR4 and CXCR7 (zeige CXCR7 Antikörper) expression resulted in increased SDF-1 (zeige CXCL12 Antikörper)-induced RF/6A cell migration and tube formation.
The CXCR7 (zeige CXCR7 Antikörper)/CXCR4/CXCL12 (zeige CXCL12 Antikörper) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
These findings suggest that FBLN5 (zeige FBLN5 Antikörper) may interfere with choroidal neovascularization by downregulating VEGF (zeige VEGFA Antikörper), CXCR4, and TGFB1 (zeige TGFB1 Antikörper) expression and inhibiting choroidl endothelial cell proliferation.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.
SDF1a (zeige CXCL12 Antikörper) directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (zeige CXCR7 Antikörper).
Hoxb8a is induced by and cooperates with Wnt (zeige WNT2 Antikörper) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Expression of Cxcr4 and Cxcl12 (zeige CXCL12 Antikörper) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (zeige CXCL12 Antikörper)/Cxcr4 pair in brain development and functioning.
show that inactivation of the estrogen receptor ESR1 (zeige ESR1 Antikörper) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (zeige ESR1 Antikörper) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A CXCR4-like chemokine receptor is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (zeige CXCL12 Antikörper)-CXCR4 system.
Knocking down CXCR4 results in severe defects in primordial germ cell migration.
SDF-1 (zeige CXCL12 Antikörper)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
chemokine (zeige CCL1 Antikörper) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
C-X-C chemokine receptor type 4
, SDF-1 receptor
, Stromal cell-derived factor 1 receptor
, chemokine (C-X-C motif) receptor 4
, chemokine (C-X-C) receptor 4
, chemokine receptor 4
, leukocyte-derived seven transmembrane domain receptor
, leukocyte-expressed seven-transmembrane-domain
, pre-B-cell-derived chemokine receptor
, stromal cell-derived factor 1 receptor
, CXC chemokine receptor
, chemokine receptor (LCR1)
, CD184 antigen
, leukocyte-derived seven-transmembrane-domain receptor
, lipopolysaccharide-associated protein 3
, neuropeptide Y receptor Y3
, seven transmembrane helix receptor
, seven-transmembrane-segment receptor, spleen
, C-X-C chemokine receptor type 4-B
, SDF-1 receptor B
, SDF-1 receptor-B
, Stromal cell-derived factor 1 receptor-B
, stromal cell-derived factor 1 receptor B
, chemokine receptor CXCR4
, CXC chemokine receptor 4