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Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.
Collectively, these results demonstrate that14-3-3/14-3-3varsigma participates in the regulation of retinal axon elongation, in part by modulating XAC activity.
Gastrulation movement requires ADF/cofilin activity through dynamic regulation of its phosphorylation state.
proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish
Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability
Data suggest that actin-interacting protein 1 (AIP1) and twinstar protein (Drosophila cofilin gene) achieve an optimal balance between resistance to tissue tension and morphogenesis.
study of the structure, backbone dynamics, and biochemical activities of Twinstar; strong affinity for ADP-G-Actin and ATP-G-Actin; mild F-actin depolymerizing activity and stable interaction with F-actin
Taken together, our data suggest that Tsr is required for cell survival and tissue growth by regulating JNK and Yki signaling while maintaining the epithelial integrity by controlling cell junctions. This study provides an insight into potential roles of ADF/cofilin in invasive cell migration and tumor suppression in higher animals.
Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties
Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.
tsr is required for planar cell polarity patterning.
These results indicate that changes in the extent of cofilin phosphorylation are regulated by Ssh in response to changes in the levels and/or organisation of F-actin.
Results show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for elongation of the retinal cell body and the morphogenesis of the rhabdomere.
During sperm capacitation, the F-actin severing proteins gelsolin and cofilin are inactive and they undergo activation prior to the acrosomal exocytosis. (Review)
High phosphorylated CFL1 expression is associated with dilated cardiomyopathy.
Cofilin 1 expression may be involved in the pathophysiology of bronchopulmonary dysplasia via dysregulation of actin binding proteins
In conclusion, deregulation of cytoskeleton dynamics through TESK1/CFL1 pathway underlies epithelial intestinal dysfunction in the small bowel mucosa of diarrhea-predominant irritable bowel syndrome, particularly in female patients.
High CFL1 expression is associated with malignant pancreatic lesions.
High CFL1 expression is associated with epithelial-mesenchymal transition of gastric cancer.
Cofilin-1 plays a dominant role in angiotensin-(1-7)-induced G0/G1 arrest and autophagy to maintain cellular homeostasis in human aortic endothelial cells
NKCC1 not only controls cell volume and Cl- concentration, but it can also regulate the actin cytoskeleton through Cofilin 1.
The enhancement of cancer cells invasion is dependent on CFL1, a known regulator of invadopodia maturation.
The present study demonstrates that miR-145 plays an important role in inhibiting cell migration by directly targeting PAK4, and identifies miR-145-PAK4-LIMK1-cofilin as a novel regulatory pathway that contributed to colorectal cancer metastasis.
D44 and RHOA are required for CFL1 phosphorylation and cell migration induced by CD74 in breast cancer cells.
Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.
Our study indicates that Cofilin 1 holds an important position in the development and progression of human bladder cancer
Results suggest that the immune-complex (IC) of cofilin-1 in sera is a potentially attractive serum biomarker for the prognosis of pancreatic ductal adenocarcinoma (PDAC).
High cofilin expression is associated with adrenocortical tumor.
In advance urothelial cancer, overexpression of nuclear cofilin correlates with bladder cancer progression.
Report structural basis for noncanonical substrate recognition of cofilin-1/LIMK1 to regulation actin cytoskeleton dynamics.
STMN1,COF1 and PAIRBP1 thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 and POSTN were connected to low grade tumors with better prognosis
We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1) gene expressions in metabolic syndrome patients.
Therefore, miR-138/LIMK1/cofilin may be considered a potential therapeutic target for the treatment of non-small cell lung cancer
Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation
Cyclic compression for 10 min up-regulated gene expression for the actin depolymerising proteins, cofilin and destrin.
This study evaluated four mouse models of brain ischemia to define the conditions that drive formation of cofilin-actin rods. Where acute reperfusion occurred, rod formation was maximal within 4 hours after reperfusion. Where infarction occurred, rods continued to form for at least 24 hours after ischemic onset, and extended into the adjacent non-ischemic tissue.
this study reports that 5'UTR of cofilin mRNA contains an internal ribosome entry site (IRES) element, and cofilin is predominantly translated by IRES-mediated mechanism in neurons.
These findings suggest a causal relationship between increased Rac1-cofilin signaling, synaptic defects, and impaired sensory processing in fragile X syndrome (FXS) and uncover a previously unappreciated role for impaired Rac1-cofilin signaling in the aberrant spine morphology and spine density associated with FXS.
Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 activity
These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin, CTTN, and the microtubule + ends.
the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.
VEGFA induced phosphorylation of Pak1 and its effector cofilin in a manner that was dependent on time as well as p38MAPKbeta.
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
These results strongly support the active role of cofilin in ischemia-induced neuronal degeneration and apoptosis.
Caspase-11 targets cofilin via the RhoA GTPase, whereas caspase-1 engages the Slingshot phosphatase
aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1.
novel roles for actin-depolymerizing factor and cofilin-1 in regulating the remodeling and permeability of epithelial junctions
reelin and cofilin cooperate in controlling cytoskeletal dynamics during neuronal migration.
The data of this study identify overlapping functions for ADF and n-cofilin in presynaptic physiology and vesicle in mice. trafficking.
Actin depolymerizing factor/cofilin double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.
On the basal side of the neural plate, loss of CFL1 has the opposite effect on myosin: excess F-actin and myosin accumulate and the ectopic myosin light chain is phosphorylated.
LIMK1 and Cofilin phosphorylation depends on PKA and is essential for mouse sperm acrosomal exocytosis
prion protein is a co-receptor mediating neuronal cofilin-actin rod formation induced by beta-amyloid and proinflammatory cytokines
The principal role of cofilin in lamellipodia at steady state is to break down F-actin, control filament turnover, and regulate the rate of retrograde flow.
Subsequent analysis by MALDI-MS identified cofilin as one of the most prominently upregulated cytoskeletal protein in pulmonary hypertension
In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2.
glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx
Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
, non-muscle cofilin 1
, cofilin 1 (non-muscle)
, Cofilin/actin depolymerizing factor-like
, actin-depolymerizing factor
, no terminal filament
, twin star
, 18 kDa phosphoprotein
, cofilin, non-muscle isoform