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Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.
Gastrulation movement requires ADF/cofilin activity through dynamic regulation of its phosphorylation state.
proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish
Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability
Taken together, our data suggest that Tsr is required for cell survival and tissue growth by regulating JNK (zeige MAPK8 Proteine) and Yki (zeige YAP1 Proteine) signaling while maintaining the epithelial integrity by controlling cell junctions. This study provides an insight into potential roles of ADF/cofilin in invasive cell migration and tumor suppression in higher animals.
Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties
Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.
tsr is required for planar cell polarity patterning.
These results indicate that changes in the extent of cofilin phosphorylation are regulated by Ssh in response to changes in the levels and/or organisation of F-actin.
Results show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for elongation of the retinal cell body and the morphogenesis of the rhabdomere.
High CFL1 (zeige VPS72 Proteine) expression is associated with malignant pancreatic lesions.
High CFL1 (zeige VPS72 Proteine) expression is associated with epithelial-mesenchymal transition of gastric cancer.
Cofilin-1 plays a dominant role in angiotensin-(1-7)-induced G0/G1 arrest and autophagy to maintain cellular homeostasis in human aortic endothelial cells
NKCC1 (zeige SLC12A2 Proteine) not only controls cell volume and Cl- concentration, but it can also regulate the actin cytoskeleton through Cofilin 1.
The enhancement of cancer cells invasion is dependent on CFL1 (zeige VPS72 Proteine), a known regulator of invadopodia maturation.
The present study demonstrates that miR (zeige MLXIP Proteine)-145 plays an important role in inhibiting cell migration by directly targeting PAK4 (zeige PAK4 Proteine), and identifies miR (zeige MLXIP Proteine)-145-PAK4 (zeige PAK4 Proteine)-LIMK1 (zeige LIMK1 Proteine)-cofilin as a novel regulatory pathway that contributed to colorectal cancer metastasis.
D44 and RHOA (zeige RHOA Proteine) are required for CFL1 (zeige VPS72 Proteine) phosphorylation and cell migration induced by CD74 (zeige CD74 Proteine) in breast cancer cells.
Our results revealed that CKS1 (zeige CKS1B Proteine) is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 (zeige PAK2 Proteine) stability.
Our study indicates that Cofilin 1 holds an important position in the development and progression of human bladder cancer
Results suggest that the immune-complex (IC) of cofilin-1 in sera is a potentially attractive serum biomarker for the prognosis of pancreatic ductal adenocarcinoma (PDAC).
Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation
Cyclic compression for 10 min up-regulated gene expression for the actin depolymerising proteins, cofilin and destrin (zeige DSTN Proteine).
this study reports that 5'UTR of cofilin mRNA contains an internal ribosome entry site (IRES) element, and cofilin is predominantly translated by IRES-mediated mechanism in neurons.
These findings suggest a causal relationship between increased Rac1-cofilin signaling, synaptic defects, and impaired sensory processing in fragile X (zeige FMR1 Proteine) syndrome (FXS) and uncover a previously unappreciated role for impaired Rac1-cofilin signaling in the aberrant spine morphology and spine density associated with FXS.
Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 (zeige CRMP1 Proteine) activity
These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin, CTTN (zeige CTTN Proteine), and the microtubule + ends.
the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.
VEGFA (zeige VEGFA Proteine) induced phosphorylation of Pak1 (zeige PAK1 Proteine) and its effector cofilin in a manner that was dependent on time as well as p38MAPKbeta.
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
These results strongly support the active role of cofilin in ischemia-induced neuronal degeneration and apoptosis.
Caspase-11 (zeige CASP4 Proteine) targets cofilin via the RhoA GTPase, whereas caspase-1 (zeige CASP1 Proteine) engages the Slingshot phosphatase
aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1.
In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2 (zeige LIMK2 Proteine).
glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx
Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
, non-muscle cofilin 1
, cofilin 1 (non-muscle)
, Cofilin/actin depolymerizing factor-like
, actin-depolymerizing factor
, no terminal filament
, twin star
, 18 kDa phosphoprotein
, cofilin, non-muscle isoform