anti-EGR1 (EGR1) Antikörper

Human Early Growth Response 1 (EGR1) Interaktionspartner

1. Hyperglycemic induction of Egr-1 and absence of NAB-2 repression in retinal endothelium, up-regulates downstream genes involved in pro-thrombotic and pro-inflammatory pathways linking Egr-1 to diabetes mediated vascular aberration of retina.

2. CacyBP expression is regulated by E2F1, EGR1, and CREB transcription factors in colorectal cancer HCT116 cells.

3. The differential binding of transcription factor EGR1 to the SNP rs5751348 genomic region with the different genotypes in the A4GALT gene leads to differential activation of P(1) -A4GALT and P(2) -A4GALT expression.

4. High EGR1 expression is associated with thyroid cancer progression.

5. Egr-1 regulates mindin expression by directly binding to the mindin promoter; mindin suppresses colon cancer progression by blocking angiogenesis.

6. The novel EGR1-CCND1 axis contributes to the G1 phase arrest and cell proliferation in glioma

7. we determined that REC8 interacted with EGR1, and inhibited EMT in gastric cancer cells. We thus propose further studies of the pathways associated with REC8 and EGR1 to potentially find novel targets in the treatment for gastric cancer.

8. ATF3 and EGR1 are involved in the beginning of inflammatory processes. Whether these two transcription factors act as tumour suppressors or promoters is context dependent and warrants analysis in further studies

9. Data (including date from studies in knockout mice) suggest that EGR1 is essential in response of airway epithelium to urban pollution/particulate matter (PM); particulate matter induces rapid up-regulation of expression of EGR1 in human bronchial epithelial cells and of Egr1 in mouse lungs. Egr1 knockout mice exhibit significantly reduced airway inflammation and mucus hyper-production in response to PM exposure in vivo.

10. p16 inhibits the tenogenic differentiation oftendon stem/progenitor cells through enhancing the transcription of miR-217 and thereby decreasing the expression of EGR1.

11. Highly expressed Egr-1 may be involved in the recruitment of RNA POL II in GDNF promoter II in a non-binding manner, and thereby involved in regulating GDNF transcription in high-grade glioma cells.

12. SARS coronavirus papain-like protease significantly triggered Egr-1 dependent activation of TGF-beta1 promoter via reactive oxygen species/p38 MAPK/STAT3 pathway.

13. Decreased EGR1 expression is associated with nasopharyngeal carcinoma.

14. results provide new insights into EGR-1/ASPP1 regulatory loop in sensitizing Quercetin-induced apoptosis. EGR-1/ASPP1, therefore, may be potentially used as therapeutic targets to improve cancer's response to pro-apoptosis treatments.

15. EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways.

16. Egr-1 upregulation is characteristic of the cardiovascular disease pathogenesis. (Review)

17. aberrant Egr1 expression, which can be suppressed by miR-181a-5p directly, plays a crucial role in the progression of renal Tubulointerstitial fibrosis in diabetic nephropathy.

18. Data suggest the EGR1-miR-30a-5p-NEUROD1 axis might serve as a promising biomarker for diagnosis and treatment monitoring for schizophrenic patients in acute psychotic state. EGR1 and miR-30a-5p were remarkably downregulated, whereas NEUROD1 was significantly upregulated in PBMNCs from patients in acute psychotic state.

19. The Egr-1 is essential for CSE-induced MUC5AC production in HBE cells likely through interaction with and modulation of AP-1, and re-emphasize targeting Egr-1 as a novel therapeutic strategy for COPD.

20. Finally, the authors show that EGFR-ERK1/2 and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 upregulation.

Mouse (Murine) Early Growth Response 1 (EGR1) Interaktionspartner

1. Tet1 overexpression affected adult neurogenesis with oligodendrocyte differentiation in the hippocampal dentate gyrus of Tet1-TG mice. In addition, Tet1 overexpression induced the elevated expression of immediate early genes, such as Egr1, c-fos, Arc, and Bdnf, followed by the activation of intracellular calcium signals in prefrontal and hippocampal neurons.

2. Our study provides strong evidence that Egr1 is a transcriptional activator of NOX4 in oxidative stress of DKD. Egr1 contributes to diabetic kidney disease by enhancing EMT, in part by targeting NOX4.

3. these results revealed that EGR-1 appears to facilitate VACV replication in starved fibroblasts by affecting viral particles infectivity.

4. EGR1-deficient mice displayed a reduced locomotor activity and altered temperature regulation. EGR1-deficient mice displayed disrupted activity rhythm with no measurable endogenous period length. The daily rhythm of BMAL1 mRNA was completely abolished in the EGR1-deficient mice.

5. Egr1(-/-) mice on the C57BL/6 background have normal eyelid development, but back-crossing to BALB/c background for four or five generations resulted in defective eyelid development by day E15.5.

6. Data (including date from studies in knockout mice) suggest that EGR1 is essential in response of airway epithelium to urban pollution/particulate matter (PM); particulate matter induces rapid up-regulation of expression of EGR1 in human bronchial epithelial cells and of Egr1 in mouse lungs. Egr1 knockout mice exhibit significantly reduced airway inflammation and mucus hyper-production in response to PM exposure in vivo.

7. Early growth response protein 1 regulates promoter activity of alpha-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system

8. ATF3 inhibit the expression and release of TNF-alpha, IL-1beta, IL-6, and IL-18 induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1/Fyn signaling pathway.

9. Egr-1 deficiency attenuates NF-kappaB and TGFbeta-mediated renal inflammation/fibrosis.

10. miR-301b promotes the proliferation, migration, and aggressiveness of human bladder cancer cells by inhibiting the expression of EGR1

11. Egr-1 upregulation is characteristic of the cardiovascular disease pathogenesis. (Review)

12. Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.

13. Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model.

14. Egr-1 is a novel regulator of drebrin expression, which is linked to changes in dendritic spine density

15. In the present study, we have investigated the contribution of element C to Krox20 expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 initial expression in r3.

16. HAS2-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1-stimulated CD44V6/ERK/EGR1 signaling.

17. Egr1 expression is sensitive to mechanical signals in tendon cells.

18. age-related up-regulation of EGR1 promotes granulosa cell apoptosis in follicle atresia during ovarian aging.

19. data indicate that Egr-1 promotes Abeta synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 plays role in activation of BACE-1 and acceleration of Abeta synthesis in AD brain.

20. EGR1, an early growth response factor, is a critical transcription factor that regulates the hepatic clock circuit.

Cow (Bovine) Early Growth Response 1 (EGR1) Interaktionspartner

1. Suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells.

2. EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG gene expression.

3. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.

4. The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.

5. EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.

Pig (Porcine) Early Growth Response 1 (EGR1) Interaktionspartner

1. Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.

2. Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.

Rabbit Early Growth Response 1 (EGR1) Interaktionspartner

1. Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.

2. Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12/Smad1/5/8 pathway.

3. Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB-mediated transactivation.

Zebrafish Early Growth Response 1 (EGR1) Interaktionspartner

1. egr1 colocalizes with tyrosine hydroxylase in the olfactory bulb throughout brain development.

2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

3. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization

4. Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.

Rhesus Monkey Early Growth Response 1 (EGR1) Interaktionspartner

1. Investigation of EGR1 indicates that its downregulation in simian immunodeficiency virus encephalitis may occur as a consequence of the host response to infection, leading to deficits in cognition.