anti-EGR1 (EGR1) Antikörper

Human Early Growth Response 1 (EGR1) Interaktionspartner

1. The novel EGR1-CCND1 (zeige CCND1 Antikörper) axis contributes to the G1 phase arrest and cell proliferation in glioma

2. we determined that REC8 (zeige REC8 Antikörper) interacted with EGR1, and inhibited EMT (zeige ITK Antikörper) in gastric cancer cells. We thus propose further studies of the pathways associated with REC8 (zeige REC8 Antikörper) and EGR1 to potentially find novel targets in the treatment for gastric cancer.

3. ATF3 (zeige ATF3 Antikörper) and EGR1 are involved in the beginning of inflammatory processes. Whether these two transcription factors act as tumour suppressors or promoters is context dependent and warrants analysis in further studies

4. Data (including date from studies in knockout mice) suggest that EGR1 is essential in response of airway epithelium to urban pollution/particulate matter (PM); particulate matter induces rapid up-regulation of expression of EGR1 in human bronchial epithelial cells and of Egr1 in mouse lungs. Egr1 knockout mice exhibit significantly reduced airway inflammation and mucus hyper-production in response to PM exposure in vivo.

5. p16 inhibits the tenogenic differentiation oftendon stem/progenitor cells through enhancing the transcription of miR (zeige MLXIP Antikörper)-217 and thereby decreasing the expression of EGR1.

6. Highly expressed Egr-1 may be involved in the recruitment of RNA POL II in GDNF promoter II in a non-binding manner, and thereby involved in regulating GDNF transcription in high-grade glioma cells.

7. SARS (zeige SARS Antikörper) coronavirus papain-like protease significantly triggered Egr-1 dependent activation of TGF-beta1 (zeige TGFB1 Antikörper) promoter via reactive oxygen species/p38 MAPK (zeige MAPK14 Antikörper)/STAT3 (zeige STAT3 Antikörper) pathway.

8. Decreased EGR1 expression is associated with nasopharyngeal carcinoma.

9. results provide new insights into EGR-1/ASPP1 (zeige PPP1R13B Antikörper) regulatory loop in sensitizing Quercetin-induced apoptosis. EGR-1/ASPP1 (zeige PPP1R13B Antikörper), therefore, may be potentially used as therapeutic targets to improve cancer's response to pro-apoptosis treatments.

10. EGR1 is a key player in the transcriptional control of miR (zeige MLXIP Antikörper)-203a, and that miR (zeige MLXIP Antikörper)-203a acts as an anti-oncogene (zeige RAB1A Antikörper) to suppress HCC (zeige FAM126A Antikörper) tumorigenesis by targeting HOXD3 (zeige HOXD3 Antikörper) through EGFR (zeige EGFR Antikörper)-related cell signaling pathways.

Mouse (Murine) Early Growth Response 1 (EGR1) Interaktionspartner

1. these results revealed that EGR-1 appears to facilitate VACV replication in starved fibroblasts by affecting viral particles infectivity.

2. EGR1-deficient mice displayed a reduced locomotor activity and altered temperature regulation. EGR1-deficient mice displayed disrupted activity rhythm with no measurable endogenous period length. The daily rhythm of BMAL1 (zeige ARNTL Antikörper) mRNA was completely abolished in the EGR1-deficient mice.

3. Egr1(-/-) mice on the C57BL/6 background have normal eyelid development, but back-crossing to BALB/c background for four or five generations resulted in defective eyelid development by day E15.5.

4. Data (including date from studies in knockout mice) suggest that EGR1 is essential in response of airway epithelium to urban pollution/particulate matter (PM); particulate matter induces rapid up-regulation of expression of EGR1 in human bronchial epithelial cells and of Egr1 in mouse lungs. Egr1 knockout mice exhibit significantly reduced airway inflammation and mucus hyper-production in response to PM exposure in vivo.

5. Early growth response protein 1 regulates promoter activity of alpha-plasma membrane calcium ATPase 2 (zeige ATP2B2 Antikörper), a major calcium pump (zeige CA-P60A Antikörper) in the brain and auditory system

6. ATF3 (zeige ATF3 Antikörper) inhibit the expression and release of TNF-alpha (zeige TNF Antikörper), IL-1beta (zeige IL1B Antikörper), IL-6 (zeige IL6 Antikörper), and IL-18 (zeige IL18 Antikörper) induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1/Fyn (zeige FYN Antikörper) signaling pathway.

7. Egr-1 deficiency attenuates NF-kappaB (zeige NFKB1 Antikörper) and TGFbeta (zeige TGFB1 Antikörper)-mediated renal inflammation/fibrosis.

8. miR (zeige MLXIP Antikörper)-301b promotes the proliferation, migration, and aggressiveness of human bladder cancer cells by inhibiting the expression of EGR1

9. Egr-1 upregulation is characteristic of the cardiovascular disease pathogenesis. (Review)

10. Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.

Cow (Bovine) Early Growth Response 1 (EGR1) Interaktionspartner

1. Suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells.

2. EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG (zeige MYOG Antikörper) gene expression.

3. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.

4. The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.

5. EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.

Pig (Porcine) Early Growth Response 1 (EGR1) Interaktionspartner

1. Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.

2. Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.

Rabbit Early Growth Response 1 (EGR1) Interaktionspartner

1. Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.

2. Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (zeige GDF7 Antikörper)/Smad1 (zeige SMAD1 Antikörper)/5/8 pathway.

3. Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (zeige CREB1 Antikörper)-mediated transactivation.

Zebrafish Early Growth Response 1 (EGR1) Interaktionspartner

1. egr1 colocalizes with tyrosine hydroxylase (zeige TH Antikörper) in the olfactory bulb throughout brain development.

2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

3. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization

4. Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.

Rhesus Monkey Early Growth Response 1 (EGR1) Interaktionspartner

1. Investigation of EGR1 indicates that its downregulation in simian immunodeficiency virus encephalitis may occur as a consequence of the host response to infection, leading to deficits in cognition.