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anti-Human EGR1 Antikörper:
anti-Mouse (Murine) EGR1 Antikörper:
anti-Rat (Rattus) EGR1 Antikörper:
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Cow (Bovine) Polyclonal EGR1 Primary Antibody für IHC, WB - ABIN2779517
Yu, de Belle, Liang, Adamson: Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. in Molecular cell 2004
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Human Monoclonal EGR1 Primary Antibody für ELISA, WB - ABIN969092
Chan, Lee, Ho, Wong, Lam, Tang, Chan, Abdullah, Wong, Lam: High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. in Clinica chimica acta; international journal of clinical chemistry 2009
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Human Monoclonal EGR1 Primary Antibody für IF, IHC (p) - ABIN560707
Bupha-Intr, Holmes, Janssen: Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium. in American journal of physiology. Heart and circulatory physiology 2007
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Human Polyclonal EGR1 Primary Antibody für ELISA, WB - ABIN560705
Hewetson, Chilton: Progesterone-dependent deoxyribonucleic acid looping between RUSH/SMARCA3 and Egr-1 mediates repression by c-Rel. in Molecular endocrinology (Baltimore, Md.) 2008
Chimpanzee Polyclonal EGR1 Primary Antibody für IHC (p), ELISA - ABIN2473413
El-Asrar, Missotten, Geboes: Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes. in Molecular vision 2011
Human Polyclonal EGR1 Primary Antibody für FACS, IF - ABIN389442
Zhang, Chen, Wang, Guang, Han, Zhang, Tan, Gu: EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression. in Scientific reports 2014
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The novel EGR1-CCND1 (zeige CCND1 Antikörper) axis contributes to the G1 phase arrest and cell proliferation in glioma
we determined that REC8 (zeige REC8 Antikörper) interacted with EGR1, and inhibited EMT (zeige ITK Antikörper) in gastric cancer cells. We thus propose further studies of the pathways associated with REC8 (zeige REC8 Antikörper) and EGR1 to potentially find novel targets in the treatment for gastric cancer.
ATF3 (zeige ATF3 Antikörper) and EGR1 are involved in the beginning of inflammatory processes. Whether these two transcription factors act as tumour suppressors or promoters is context dependent and warrants analysis in further studies
Data (including date from studies in knockout mice) suggest that EGR1 is essential in response of airway epithelium to urban pollution/particulate matter (PM); particulate matter induces rapid up-regulation of expression of EGR1 in human bronchial epithelial cells and of Egr1 in mouse lungs. Egr1 knockout mice exhibit significantly reduced airway inflammation and mucus hyper-production in response to PM exposure in vivo.
p16 inhibits the tenogenic differentiation oftendon stem/progenitor cells through enhancing the transcription of miR (zeige MLXIP Antikörper)-217 and thereby decreasing the expression of EGR1.
Highly expressed Egr-1 may be involved in the recruitment of RNA POL II in GDNF promoter II in a non-binding manner, and thereby involved in regulating GDNF transcription in high-grade glioma cells.
SARS (zeige SARS Antikörper) coronavirus papain-like protease significantly triggered Egr-1 dependent activation of TGF-beta1 (zeige TGFB1 Antikörper) promoter via reactive oxygen species/p38 MAPK (zeige MAPK14 Antikörper)/STAT3 (zeige STAT3 Antikörper) pathway.
Decreased EGR1 expression is associated with nasopharyngeal carcinoma.
results provide new insights into EGR-1/ASPP1 (zeige PPP1R13B Antikörper) regulatory loop in sensitizing Quercetin-induced apoptosis. EGR-1/ASPP1 (zeige PPP1R13B Antikörper), therefore, may be potentially used as therapeutic targets to improve cancer's response to pro-apoptosis treatments.
EGR1 is a key player in the transcriptional control of miR (zeige MLXIP Antikörper)-203a, and that miR (zeige MLXIP Antikörper)-203a acts as an anti-oncogene (zeige RAB1A Antikörper) to suppress HCC (zeige FAM126A Antikörper) tumorigenesis by targeting HOXD3 (zeige HOXD3 Antikörper) through EGFR (zeige EGFR Antikörper)-related cell signaling pathways.
these results revealed that EGR-1 appears to facilitate VACV replication in starved fibroblasts by affecting viral particles infectivity.
EGR1-deficient mice displayed a reduced locomotor activity and altered temperature regulation. EGR1-deficient mice displayed disrupted activity rhythm with no measurable endogenous period length. The daily rhythm of BMAL1 (zeige ARNTL Antikörper) mRNA was completely abolished in the EGR1-deficient mice.
Egr1(-/-) mice on the C57BL/6 background have normal eyelid development, but back-crossing to BALB/c background for four or five generations resulted in defective eyelid development by day E15.5.
Early growth response protein 1 regulates promoter activity of alpha-plasma membrane calcium ATPase 2 (zeige ATP2B2 Antikörper), a major calcium pump (zeige CA-P60A Antikörper) in the brain and auditory system
ATF3 (zeige ATF3 Antikörper) inhibit the expression and release of TNF-alpha (zeige TNF Antikörper), IL-1beta (zeige IL1B Antikörper), IL-6 (zeige IL6 Antikörper), and IL-18 (zeige IL18 Antikörper) induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1/Fyn (zeige FYN Antikörper) signaling pathway.
Egr-1 deficiency attenuates NF-kappaB (zeige NFKB1 Antikörper) and TGFbeta (zeige TGFB1 Antikörper)-mediated renal inflammation/fibrosis.
miR (zeige MLXIP Antikörper)-301b promotes the proliferation, migration, and aggressiveness of human bladder cancer cells by inhibiting the expression of EGR1
Egr-1 upregulation is characteristic of the cardiovascular disease pathogenesis. (Review)
Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.
Suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells.
EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG (zeige MYOG Antikörper) gene expression.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.
Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.
Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (zeige GDF7 Antikörper)/Smad1 (zeige SMAD1 Antikörper)/5/8 pathway.
Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (zeige CREB1 Antikörper)-mediated transactivation.
egr1 colocalizes with tyrosine hydroxylase (zeige TH Antikörper) in the olfactory bulb throughout brain development.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization
Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.
Investigation of EGR1 indicates that its downregulation in simian immunodeficiency virus encephalitis may occur as a consequence of the host response to infection, leading to deficits in cognition.
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
, early growth response protein 1
, nerve growth factor-induced protein A
, transcription factor ETR103
, transcription factor Zif268
, zinc finger protein 225
, zinc finger protein Krox-24
, early growth response protein 1 (egr-1)
, Krox-24 nuclear protein
, zinc finger protein ZENK
, early growth response 1
, early growth response protein 1-A
, zinc-finger transcriptional protein
, Early growth response protein 1
, Zinc finger protein ZENK
, zenk transcription factor
, early growth response protein 1-B