SMC5 Protein (AA 1-1101) (His tag)

Produktnummer ABIN7564564

Produktdetails

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-1101

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SMC5 Protein ist gelabelt mit His tag.

Verwendungszweck: Made-to-order recombinant Smc5 Protein expressed in mammalian cells.

Sequenz: MATPSGKAAP PNPQVSKRSL PRDASSEVPS KRKNSNPLPT LPRPSGTFVE GSIVRIAMEN FLTYDICEVS PGPHLNMIIG ANGTGKSSIV CAICLGLAGK PAFMGRADKV GFFVKRGCSK GLVEIELFRT SGNLIITREI DVIKNQSFWF INKKPVTQKI VEEQVAALNI QVGNLCQFLP QDKVGEFAKL SKIELLEATE KSVGPPEMHR YHCELKNFRE KEKQLETSCK EKTEYLEKMV QRNERYKQDV ERFYERKRHL DLIEMLEAKR PWVEYENVRQ EYEGVKLIRD RVKEEVRKLK EGQIPMTRRI EEIDRQRHTL EVRIKEKSTD IKEASQKCKQ RQDLIERKDR QIKELQQALT VKQNEELDRQ KRISNTRKMI EDLQSELKTA ENCENLQPQI DTVTNDLRRV QEEKALCEGE IIDKQREKEM LEKQRRSVSD HITRFDNLMN QKEDKLRQRY RDTYDAVLWL RNNRDRFKQR VCEPIMLTIN MKDNKNAKYV ENHISSNDLR AFVFESQEDM EIFLREVRDN KKLRVNAVIA PKISYADKAP SRSLNDLKQY GFFSYLRELF DAPDPVMSYL CCQYHIHEVP VGTERTRERI ERVIQETRLK QIYTAEEKYV LKTSVYSNKV ISSNTSLKVA QFLTVTVDLE QRRHLEEQLK EMNRQLEAVD SGLAALRDTN RHLELKDNEL RLKKKELLER KTRKRQLEQK ISSKLASIRL MEQDTCNLEE EERKASTKIK EINVQKAKLV TELTGLVKIC TSFQIQKVDL ILQNTTVISE KNKLEADYMA SSSQLRVTEQ QFIELDDNRQ RLLQKCKELM KKARQVCNLS ADQAVPQEFQ TQVPTIPNGH SSSPPMAFQD LPNTLDEIDA LLTEERSRAS CFTGLNPSVV EEYSKREVEI QQLTEELQGK KVELDEYREN ISQVKERWLN PLKELVEKIN EKFSNFFSSM QCAGEVDLHT ENEEDYDKYG IRIRVKFRSS TQLHELTPHH QSGGERSVST MLYLMALQEL NRCPFRVVDE INQGMDPINE RRVFEMVVNT ACKENTSQYF FITPKLLQNL PYSEKMTVLF VYNGPHMLEP NRWNLKAFQR RRRRITFTQP Q Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Spezifität: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Produktmerkmale: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Reinheit: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Güteklasse: custom-made

Anwendungsinformationen

Applikationshinweise: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Andere Bezeichnung: Smc5 (SMC5 Produkte)

Hintergrund: Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (mSMC5) (Protein expressed in male leptotene and zygotene spermatocytes 453) (MLZ-453),FUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6 (By similarity). {ECO:0000250}.

Molekulargewicht: 128.8 kDa

UniProt: Q8CG46

AlphaFold: Q8CG46