SENP7 Protein (AA 1-1037) (His tag)

Produktnummer ABIN7564432

Produktdetails

Target: SENP7 (SUMO1/sentrin Specific Protease 7 (SENP7))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-1037

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SENP7 Protein ist gelabelt mit His tag.

Verwendungszweck: Made-to-order recombinant Senp7 Protein expressed in mammalian cells.

Sequenz: MDRARPGRRR ASSEIVTEGK RKKSSPADLQ KITKLLTVKS EDVLAQSPLS KLRGSECWWT RSLRNKVICL DHKKPKAARG CPPKGLPKRH LRVMLTNVLW TDLGREFRKT LPRKDANLCA PSKVQSDSLP STSVDSIETC QRLDPLHQSL NLSERTPRVI LTDIRQTELG RKYLKIPPVT EASLSDTANL KSEQLSSSSD GSLESCQSVN HHKSFLSESG PKPSRTGDVP AKEAACGGQK QGDDGGVTPE MAAPHPKDFN TGNKGCDYLE EGTSNKNTSY SYSEMDHTPV SRKRKKRGRS NFHDSHNSKT SLDKPTEHTK EEENDSSVSR KLEESGEDSH QDPAPPEGLA PESLESEATN LRSFAAGQEP DASAASGRAS SPNKSLESSA SSEVSENSSV AVKGEALTLK EASPPGGSSE ESQLLISAEP IVVSSDEEGP VEHKNSVILK LQPPHEIMSE NQGTSDPQLS ELTLGACESV QVTSELFPYN PDVENISCIK SNSEMDLKLD FIFTCVYIGK IKGTPKGCVT FTKKYIKIPF QVSTNEISLT VDTARLKRFG LWESKDEDHS KRSHAILFLW LSSDYLQDIQ TQLENPMLSQ QSKANEFIFL ELNSSISQRE ELKLKDIMME ISTKNGNLHL SCPLPWVQAL PLFQDLSPQE ISFLHYYYAS ASALPTAAGA DMKKKSVSQP SNSDTIKPTY TFLHKQSSGC YSLSITSSPE EEWQEVRNTG PVQKLIVYPP PPTKGGLGVT NEDLECLEEG EFLNDVIIDF YLKYLLLEKA SDELVERSHI FSSFFYKCLT RKENNLTEDN PDLSVAQRRH RRVRTWTRHI NIFNKDYIFV PVNESSHWYL AVICFPWLEE AVYEDCPQTV SQQFQGQQSQ HDHKMTDNDP HTTSTVSTSA EDSQSTEVNM SVPKKMCKRP CILILDSLKA ASIQNTVQNL REYLEVEWEV KRKTHREFSK TNMVDLCPKV PKQDNSSDCG VYLLQYVESF FQDPIVNFEL PIHLEKWFPR HVIKTKREDI RELILKLHLQ QQKGGSC Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Spezifität: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Produktmerkmale: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Reinheit: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Güteklasse: custom-made

Anwendungsinformationen

Applikationshinweise: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: SENP7 (SUMO1/sentrin Specific Protease 7 (SENP7))

Andere Bezeichnung: Senp7 (SENP7 Produkte)

Hintergrund: Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7),FUNCTION: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS (PubMed:28095500). Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (PubMed:28095500). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (By similarity). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (By similarity). Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity). {ECO:0000250|UniProtKB:Q9BQF6, ECO:0000269|PubMed:28095500}.

Molekulargewicht: 116.3 kDa

UniProt: Q8BUH8

AlphaFold: Q8BUH8