MTBP Protein (AA 1-894) (His tag)

Produktnummer ABIN7564375

Produktdetails

Target: MTBP (MDM2 Binding Protein (MTBP))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-894

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MTBP Protein ist gelabelt mit His tag.

Verwendungszweck: Made-to-order recombinant Mtbp Protein expressed in mammalian cells.

Sequenz: MDRYLLLVTW REGKFRSVAG GEIEPGTEAT SLESTDKQPD LTATNIYHLL KRSISDSIHP DDSTFPACSV GGTPHSRKWF FAVQAICGFY QFCSSDWQEI HFDAEKDKIE DVLQANIEEC QSAVECFEED DSNSRESLPL ADLYEESAEN LHQLSDKLPA PGRAMIDIIL LPSDKDPPKL KECLPIVGAL KHLKEWHSAK VIIAGSYCEI NCQKIAEYLS ASVVPLEEFR NAIDPRELWR GEIQMRERKF GFEISFPEFC LKGVTPTNVS AYNLNTCFLA KKIASSKVFH YYGPALEFVQ MIKLSDLPSC YMSDIEFELE VTGHCTRQNS MLLLEQISSL CGKVGALFVL PCTVSNVLIP PPSQLASRKW KEYMAKKPKT ISVPDVAVKG EFSGYHLLLQ GMGKRKCRAT LLHSASQING SFALSVIHGK MKTKAGEARP SFPFDFSSLP RFSEEQVLQR EKQLASFQVL ALKECLKRRK AANQPEAFSA DELKSLLALT RERFLGHFDV LPTEAALAQT DTVKAAGVVN DDGTVEPYSS SLMETNPLEW PERHVLQNLE TSEKAKQKMR TGSLPRSSEQ LLGHKEGPRD SLTLLDAKEL LKYFTSDGLP VGDLQPLHIQ RGEKPFVLTP ELSPGKLQVL PFEKASECHY HGIEYCLDDQ KALERDGGFS ELQSRLIRYE TQTTCTRDSF PVPTVLSPLP SPAVLSEPQS VPEGEALQGE LRTEVSGLKR RSKDPSCLYP QKRLTRSESS DCLPSQASCN SNHHHHTGKP RKPQAERCVS GLPLPGREAS KDTSKTSSGQ KRAHESKSSK QMKESRSQKH TRMLKEVVKD TLKRHHITEA HESFTACSQR LFDISKFYLK DLKTSRGLFE EMKKTANNNV VQVIEWVVEK MSKK Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Spezifität: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Produktmerkmale: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Reinheit: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Güteklasse: custom-made

Anwendungsinformationen

Applikationshinweise: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: MTBP (MDM2 Binding Protein (MTBP))

Andere Bezeichnung: Mtbp (MTBP Produkte)

Hintergrund: Mdm2-binding protein (  mMTBP),FUNCTION: May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. {ECO:0000269|PubMed:10906133, ECO:0000269|PubMed:15632057}.

Molekulargewicht: 100.3 kDa

UniProt: Q8BJS8

AlphaFold: Q8BJS8