MAML2 Protein (AA 1-1156) (His tag)

Produktnummer ABIN7554462

Produktdetails

Target: MAML2 (Mastermind-Like 2 (MAML2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-1156

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MAML2 Protein ist gelabelt mit His tag.

Verwendungszweck: Made-to-order recombinant MAML2 Protein expressed in mammalian cells.

Sequenz: MGDTAPPQAP AGGLGGASGA GLLGGGSVTP RVHSAIVERL RARIAVCRQH HLSCEGRYER GRAESSDRER ESTLQLLSLV QHGQGARKAG KHTKATATAA TTTAPPPPPA APPAASQAAA TAAPPPPPDY HHHHQQHLLN SSNNGGSGGI NGEQQPPAST PGDQRNSALI ALQGSLKRKQ VVNLSPANSK RPNGFVDNSF LDIKRIRVGE NLSAGQGGLQ INNGQSQIMS GTLPMSQAPL RKTNTLPSHT HSPGNGLFNM GLKEVKKEPG ETLSCSKHMD GQMTQENIFP NRYGDDPGEQ LMDPELQELF NELTNISVPP MSDLELENMI NATIKQDDPF NIDLGQQSQR STPRPSLPME KIVIKSEYSP GLTQGPSGSP QLRPPSAGPA FSMANSALST SSPIPSVPQS QAQPQTGSGA SRALPSWQEV SHAQQLKQIA ANRQQHARMQ QHQQQHQPTN WSALPSSAGP SPGPFGQEKI PSPSFGQQTF SPQSSPMPGV AGGSGQSKVM ANYMYKAGPS AQGGHLDVLM QQKPQDLSRS FINNPHPAME PRQGNTKPLF HFNSDQANQQ MPSVLPSQNK PSLLHYTQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QSSISAQQQQ QQQSSISAQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQPSSQP AQSLPSQPLL RSPLPLQQKL LLQQMQNQPI AGMGYQVSQQ QRQDQHSVVG QNTGPSPSPN PCSNPNTGSG YMNSQQSLLN QQLMGKKQTL QRQIMEQKQQ LLLQQQMLAD AEKIAPQDQI NRHLSRPPPD YKDQRRNVGN MQPTAQYSGG SSTISLNSNQ ALANPVSTHT ILTPNSSLLS TSHGTRMPSL STAVQNMGMY GNLPCNQPNT YSVTSGMNQL TQQRNPKQLL ANQNNPMMPR PPTLGPSNNN NVATFGAGSV GNSQQLRPNL THSMASMPPQ RTSNVMITSN TTAPNWASQE GTSKQQEALT SAGVRFPTGT PAAYTPNQSL QQAVGSQQFS QRAVAPPNQL TPAVQMRPMN QMSQTLNGQT MGPLRGLNLR PNQLSTQILP NLNQSGTGLN QSRTGINQPP SLTPSNFPSP NQSSRAFQGT DHSSDLAFDF LSQQNDNMGP ALNSDADFID SLLKTEPGND DWMKDINLDE ILGNNS Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Spezifität: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Produktmerkmale: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Reinheit: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Güteklasse: custom-made

Anwendungsinformationen

Applikationshinweise: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: MAML2 (Mastermind-Like 2 (MAML2))

Andere Bezeichnung: MAML2 (MAML2 Produkte)

Hintergrund: Mastermind-like protein 2 (Mam-2),FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}.

Molekulargewicht: 125.2 kDa

UniProt: Q8IZL2

AlphaFold: Q8IZL2