SLC7A11 & SLC3A2 protein-VLP

Produktnummer ABIN7489024

Produktdetails

Target: SLC7A11 & SLC3A2

Protein-Typ: VLP

Spezies: Human

Quelle: HEK-293 Cells

Verwendungszweck: Human SLC7A11&SLC3A2 Full Length Heterodimer Protein (VLP)

Sequenz: Val 2 - Leu 501 (SLC7A11) & Glu 2- Ala 630 (SLC3A2)

Produktmerkmale: Human SLC7A11&SLC3A2 Full Length Heterodimer Protein (VLP) is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 501 (SLC7A11) & Glu 2- Ala 630 (SLC3A2) (Accession # Q9UPY5 (SLC7A11) & P08195 (SLC3A2).

Endotoxin-Niveau: 1.0 EU per μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, Arginine, pH 7.4

Lagerung: -80 °C

Informationen zur Lagerung: -70°C

Antigendetails

Target: SLC7A11 & SLC3A2

Hintergrund: Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring specialised transport systems for its import into the cell. System xc- is a dedicated cystine transporter, importing cystine in exchange for intracellular glutamate. To counteract elevated levels of reactive oxygen species in cancerous cells system xc- is frequently upregulated, making it an attractive target for anticancer therapies.