Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer (AA 32-993) protein (His tag)
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Target
- Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 32-993
- Spezies
- Human
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- His tag
- Verwendungszweck
- Human Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer Protein
- Sequenz
- Leu32-Arg993 (ITGA2B) acidic tail & GLy27-Asp718 (ITGB3) basic tail
- Spezifität
- Uni-Prot: P08514-1 (ITGA2B), P05106-1 (ITGB3)
- Produktmerkmale
- Recombinant Human Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail.
- Reinheit
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1EU per μg by the LAL method.
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Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer (AA 32-988) protein (His tag)
Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- Integrin alpha 2B beta 3 (ITGA2B & ITGB3) Heterodimer
- Hintergrund
- Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.
- Molekulargewicht
- 110.5 kDa (ITGA2B)&81.3 kDa (ITGB3). Due to glycosylation, the protein migrates to 95-115 kDa based on Tris-Bis PAGE result.
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