SERPINA3N Protein (His tag)

Produktnummer ABIN7320776

Produktdetails

Target: SERPINA3N (Serine (Or Cysteine) Peptidase Inhibitor, Clade A, Member 3N (SERPINA3N))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses SERPINA3N Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Serpin A3N Protein (His Tag)

Sequenz: Phe21-Lys418

Produktmerkmale: Recombinant Mouse Serpin A3N is produced by our Mammalian expression system and the target gene encoding Phe21-Lys418 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0 .

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: SERPINA3N (Serine (Or Cysteine) Peptidase Inhibitor, Clade A, Member 3N (SERPINA3N))

Andere Bezeichnung: Serpin A3N (SERPINA3N Produkte)

Hintergrund:

Background: Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic lymphocytes, providing a means to disable cellmediated immune responses.

Synonym: Serine protease inhibitor A3N, Serpin A3N, Serpina3n, Spi2

Molekulargewicht: 45.6 kDa

UniProt: Q91WP6