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Selectin E (SELE) (AA 22-556) protein (Fc Tag) Protein

SELE Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Produktnummer ABIN2180819
$275.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle Selectin E/CD62e (SELE) Proteine anzeigen
    Selectin E/CD62e (SELE)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 22-556
    Spezies
    • 14
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Quelle
    • 18
    • 6
    • 5
    • 4
    • 3
    • 2
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Selectin E/CD62e Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 22-556
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 84.8 kDa. The protein migrates as 150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    Selectin E/CD62e (SELE)
    Andere Bezeichnung
    E-Selectin (SELE Produkte)
    Synonyme
    SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, E-selectin, Elam, selectin E, selectin, endothelial cell, SELE, Sele
    Hintergrund
    E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein.[1] It is transiently expressed on vascular endothelial cells in response to IL-1β and TNFα. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto).[2] During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels.[3] E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.
    Molekulargewicht
    84.8 kDa
    NCBI Accession
    NP_000441
    Pathways
    Thromboxane A2 Receptor Signaling
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