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beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag) Protein

B2M Spezies: Cynomolgus, Rhesusaffen Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Produktnummer ABIN2180610
$275.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle beta-2 Microglobulin (B2M) Proteine anzeigen
    beta-2 Microglobulin (B2M)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 21-119
    Spezies
    • 11
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cynomolgus, Rhesusaffen
    Quelle
    • 48
    • 12
    • 4
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses beta-2 Microglobulin Protein ist gelabelt mit His tag.
    Sequenz
    AA 21-119
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.6 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE).
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target
    beta-2 Microglobulin (B2M)
    Andere Bezeichnung
    beta 2-Microglobulin (B2M Produkte)
    Synonyme
    Ly-m11, beta2-m, beta2m, bwm, wu:fa94c05, wu:fb10a09, b2m-W01, b2m-W03, b2m-Z01, b2m-Z02, b2m-Z03, B2M, b2m, B2MG, b-2-m, beta-2-microglobulin, beta-2 microglobulin, beta-2-microglobulin S homeolog, B2M, B2m, b2m, b2m.S
    Hintergrund
    β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).
    Molekulargewicht
    12.6 kDa
    UniProt
    Q8SPW0
    Pathways
    T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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