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data indicate that SWAP-70 may be involved in regulating motility of trophoblast cells during embryonic implantation and placentation.
Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs).
findings show characteristic changes in the lipidome of CD11c (zeige ITGAX Proteine)+ immune cells upon their activation, and reveal an important role of SWAP-70 in the selective generation and localization of ceramides
DEF6 (zeige DEF6 Proteine) and SWAP70 are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology
SWAP-70 is not a typical oncogene (zeige RAB1A Proteine), but is required for spontaneous transformation of mouse embryo fibroblasts.
These findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks.
Cells expressing the mutant SWAP-70 exhibited faster growth than the parental or wild-type SWAP-70-expressing cells underscoring its role in neoplastic transformation.
SWAP-70 is not required for podosome formation and F-actin turnover in dendritic cells.
SWAP-70 deficiency reveals two pathways that contribute to spontaneous maturation of DCs.
SWAP-70 controls IgE production through regulation of the antagonistic STAT6 and BCL6 occupancy of the germline IgE promoter
A novel function of the F-actin binding and regulatory protein (zeige TGFB1 Proteine) SWAP-70 in osteoclast biology, is reported.
Expression of switch-associated protein 70 is associated with lymphocyte activation and reduced disability in multiple sclerosis.
These data show a key role for SWAP70 as a scaffold for tethering the peripheral actin cage to phagosomes.
SWAP70 appears to act as a molecular intermediate between vGPCR and endothelial activation.
SWAP70 may be a target of miR (zeige MLXIP Proteine)-145, and it might have a potential oncogenic function.
Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in Multiple Sclerosis relapse pathogenesis
The unwinding of the C-terminal alpha-helix could regulate the functions of SWAP-70 at the plasma membrane surface.
findings suggest that regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure
Overexpression of SWAP-70 altered the actin organization and lamellipodial morphology
the binding activity of SWAP-70 to non-muscle F-actin is required for membrane ruffling.
surface expression of SWAP-70 on HIV-1 infected cells as well as PBMCs; SWAP-70 may serve as a marker for T cell differentiation as well as for HIV-1 infection
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
SWAP switching B-cell complex 70kDa subunit
, SWAP-70 protein
, switch-associated protein 70-like
, SWAP complex protein, 70 kDa
, switch-associated protein 70
, SWA-70 protein
, SWAP complex protein