SWAP Switching B-Cell Complex 70kDa Subunit Proteine (SWAP70)

Human SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70) Interaktionspartner

1. Expression of switch-associated protein 70 is associated with lymphocyte activation and reduced disability in multiple sclerosis.

2. These data show a key role for SWAP70 as a scaffold for tethering the peripheral actin cage to phagosomes.

3. SWAP70 appears to act as a molecular intermediate between vGPCR and endothelial activation.

4. SWAP70 may be a target of miR-145, and it might have a potential oncogenic function.

5. Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in Multiple Sclerosis relapse pathogenesis

6. The unwinding of the C-terminal alpha-helix could regulate the functions of SWAP-70 at the plasma membrane surface.

7. findings suggest that regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure

8. protein that functions as the only B cell-specific component of an isotype switch recombination

9. Overexpression of SWAP-70 altered the actin organization and lamellipodial morphology

10. the binding activity of SWAP-70 to non-muscle F-actin is required for membrane ruffling.

11. surface expression of SWAP-70 on HIV-1 infected cells as well as PBMCs; SWAP-70 may serve as a marker for T cell differentiation as well as for HIV-1 infection

12. SWAP-70 may be involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation in primates.

Mouse (Murine) SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70) Interaktionspartner

1. Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs).

2. findings show characteristic changes in the lipidome of CD11c+ immune cells upon their activation, and reveal an important role of SWAP-70 in the selective generation and localization of ceramides

3. DEF6 and SWAP70 are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology

4. SWAP-70 is not a typical oncogene, but is required for spontaneous transformation of mouse embryo fibroblasts.

5. These findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks.

6. Cells expressing the mutant SWAP-70 exhibited faster growth than the parental or wild-type SWAP-70-expressing cells underscoring its role in neoplastic transformation.

7. SWAP-70 is not required for podosome formation and F-actin turnover in dendritic cells.

8. SWAP-70 deficiency reveals two pathways that contribute to spontaneous maturation of DCs.

9. SWAP-70 controls IgE production through regulation of the antagonistic STAT6 and BCL6 occupancy of the germline IgE promoter

10. A novel function of the F-actin binding and regulatory protein SWAP-70 in osteoclast biology, is reported.

11. regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure.

12. SWAP-70 regulates erythropoiesis by controlling alpha4 integrin.

13. in a dose-dependent manner, SWAP-70 controls IRF-4 protein expression and thereby regulates the initiation of plasma cell differentiation

14. SWAP-70-374 can activate some signaling pathways, including the ERK1/2 pathway, to transform MEFs

15. These data demonstrate SWAP-70 as a novel regulator of S1P signaling necessary for dendritic cell motility and endocytosis.

16. regulator of the cell adhesion and B-cell differentiation

17. In mast cells SWAP-70 plays a role both in establishing the initial competence to degranulate and to develop into mature mast cells.

18. SWAP-70 is an important regulator of specific effector pathways in c-kit signaling, including mast cell activation, migration, and cell adhesion

19. These data identify SWAP-70 as a transient component of early macropinosomes.

20. SWAP-70 deficiency uncouples germinal center formation from T-dependent antibody and long-lived plasma cell production and causes extrafollicular generation of high-affinity plasma cells, but does not adequately support the memory response.

Rhesus Monkey SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70) Interaktionspartner

1. data indicate that SWAP-70 may be involved in regulating motility of trophoblast cells during embryonic implantation and placentation.