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Brain gene expression of PADI2, ZNF385A, PSD2, and A2ML1 and DNA methylation dysregulations are implicated in the alteration of brain tissue properties associated with late-life cognitive decline above and beyond the influence of common neuropathologic conditions.
Results suggest that RZF is a shuttling regulatory protein expressed in photoreceptors of the human retina that may be involved in mRNA or protein regulation of photoreceptor-specific genes and therefore have role in retinal disease mechanisms.
DISC1 binds ITPR1 mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity.
Hzf and HuR independently associate with the 3'UTR of p53 mRNA and together regulate the translation of p53 mRNA and regulate the nuclear export of p53 mRNA in response to signals that induce p53 activation.
Hzf is essential for megakaryopoiesis and hemostasis in vivo
Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA, a process that is impaired in Hzf mutant mice
In the present study we demonstrated that mice lacking Hzf (Hzf(-/-) mice) exhibited severe impairments of motor coordination and cerebellum-dependent motor learning.
Hzf determines cell survival under genotoxic stress by modulating p53 transactivation.
Hzf physically interacts with the 3' untranslated region of C/EBPalpha mRNA to enhance its translation during adipogenesis.
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004
hematopoietic zinc finger protein
, retinal zinc finger protein
, zinc finger protein 385
, zinc finger protein 385A