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These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
U1 localized in the preoptic area, periventricular hypothalamic and tectal regions, and dorsal part of the trigeminal motor nucleus and several nuclei of the dorsal telencephalon.
Results describe the distribution of urotensin I, UIIalpha and UIIbeta mRNAs in different organs and the cellular localization of the three mRNAs in the spinal cord by in situ hybridization (ISH) histochemistry.
REVIEW: Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?
In women with chronic pelvic pain, infertility, or both symptoms, the probability of endometriosis (positive predictive value) increased consistently with the increase of plasma Ucn1 levels.
Study found reduced miR-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced its levels.
In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma.
UCN I is secreted from human glioblastoma cells by exocytosis through constitutive secretory granules.
Findings identify Ucn as a potential mediator that inhibits TGFbeta1 oncogenic signaling in breast neoplasm.
In women with adnexal endometrioma versus teratoma, the medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (p > 0.05), respectively.
Ucn1 prevents the development of atherosclerosis by suppressing EC inflammatory response and proliferation, macrophage foam cell formation, and VSMC migration and proliferation
These data suggest that UVB-stimulated Ucn1 contributes to TRP1 production via the transcription of both Nurr-1 and Nur77. Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.
down-regulated expression in the placenta and maternal serum during intrahepatic cholestasis of pregnancy may impair the blood flow regulation of the utero-placental-fetal unit and contribute to fetal distress
Production of CRF and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria.
Cardioplegic arrest failed to induce cardiac myocyte overexpression of urocortin in diabetic hearts.
Urocortin expression inversely correlates with higher tumor grade and advanced tumor stage in gastric adenocarcinomas.
all neonates expressed UCN1 in the Edinger-Westphal nucleus independent of the degree of neuropathological injury.
Ucn is both an essential chondrocyte survival signal peptide and a chondroprotective agent in the presence of pro-apoptotic stimuli.
A detailed conformational model for the CRF1R-Ucn1 complex based on the many ligand-receptor interactions determined was here and eventually revealed unique features of peptide ligand binding to class B GPCRs.
during the midluteal phase of the cycle, metformin may decrease the production of corticotropin-releasing hormone and UCN in the endometrium.
in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation.
Data suggest that low urocortin-1 concentration in midtrimester amniotic fluid is an early indicative marker of preterm birth.
Serum urocortin could not predict women who delivered preterm among women with signs of preterm labor.
Genetic deletion of Ucn1 reduced high levels of intake and preference across 2 weeks of continuous access drinking when alcohol concentrations were increased from 10 to 20 to 40%. Ucn1 deletion did not alter low-level drinking when the alcohol concentration remained at 10%.
Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus
it is shown that CRH and UCN upregulate galectin-1 expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1.
This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
CNTF activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo.
The absence of the CB1 receptor alters the Ucn1 mRNA and peptide levels in Edinger-Westphal nucleus neurones, concomitant with an augmented stress response and increased anxiety-like behaviour.
EWcp-Ucn1 neurons play an important role in EtOH intake, preference, and reward.
CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise
Data suggest that UCN regulates osteoclast resorption by suppressing osteoclast maturation/function via suppression of constitutively active cation channel (CRFR2beta) with properties of canonical transient receptor potential 1 (TRPC1) channel.
Ucn1 gene was downregulated in 5-HTT KO and upregulated in 5-HTT TG mice which exhibit opposite changes in anxiety-related behavior; findings suggesti this peptide can be involved in behavioral changes observed in 5-HTT mutant mice
This study provides provide evidence for leptin actions that go beyond the hypothalamus and proposes that leptin can directly influence the activity of the midbrain Ucn1 neurons.
The lack of brain Ucn 1 immunoreactivity at birth and the gradual postnatal increase in Ucn 1 in the perioculomotor area suggests that this peptide plays a greater behavioral role in adulthood than during the early postnatal development of an organism.
Ucn1, CART and nesfatin-1/NUCB2 are specifically involved in the response of Edinger-Westphal nucleus neurons to acute stress in the mouse
Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior.
Edinger-Westphal nucleus urocortin-expressing neurons mount a response to acute challenge in transgenic mice overexpressing corticotropin-releasing factor.
Urocortin induces macrophage apoptosis via Corticotropin-Releasing Factor Receptor-2.
Dorsal raphe is a neuroanatomical substrate of urocortin 1-induced reductions in feeding.
UCN and AM prevent lethal endotoxemia by decreasing the local and systemic levels of a wide spectrum of inflammatory mediators, including cytokines, chemokines, and the acute phase protein serum amyloid A
CRF and urocortin promote the survival of cultured cerebellar GABAergic neurons through the type 1 CRF receptor
An important role for UCN1 in the HPA axis adaptation to repeated restraint and in the corticosterone response to a cold environment.
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
, urocortin, preproprotein