anti-Dopamine d2 Receptor (DRD2) Antikörper

Human Dopamine Receptor D2 (DRD2) Interaktionspartner

1. We analysed AMPK phosphorylation, dopamine D2 receptor (D2R), and oestrogen receptor (ER) expression in both BC-sensitive and -resistant PRLoma samples; effects of the AMPK agonist MET (alone or with BC) on in vitro proliferation and apoptosis, xenograft growth and prolactin (PRL) secretion of BC-sensitive and -resistant cells, and ER expression in xenografts.

2. we observed a significant pattern revealing positive associations of striatal as well as extrastriatal DA D2/3 receptors to BOLD response in the thalamo-striatal-cortical circuit, which supports white matter functioning

3. The DRD2 Taq1A (A2/A1 or C/T) polymorphism is associated with Wilson disease and some of its clinical attributes. The A1A1 genotype of DRD2 Taq1A polymorphism was significantly more common among patients with rigidity.

4. The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface.

5. Meta-analysis suggested that a significant association between DRD2 TaqIA polymorphism and Parkinson disease under the recessive genetic mode, and additive genetic models, especially in Caucasians.

6. Role of TaqI DRD2 (rs1800497) and DRD4 VNTR Polymorphisms in Posttraumatic Stress Disorder

7. These data suggest that DRD2 Taq1 gene polymorphisms influence the eating behavior and preference/intake frequency/craving of certain high-fat foods in Malaysian adults, but their role in obesity and adiposity is still inconclusive and needs further investigation.

8. The Met allele of the rs6275 SNP is associated with lower DRD2 receptor density, resulting in less auto-regulating, pre-synaptic activity and higher dopamine signaling.The Met/Met homozygotes had greater average moderate to vigorous physical activity during the Lifestyle training interventions.

9. The DRD2 Taq I polymorphism had statistically significant effects on posttraumatic stress disorder

10. The association between the DRD2 gene promoter region polymorphisms and Schizophrenia in the northern Chinese Han population was not found.

11. we failed to identify any associations of DRD2 rs1800497, DRD4 120 bp Ins, or DRD4 exon III polymorphisms with aggression in African populations of Hadza and Datoga

12. The current meta-analysis suggests that ANKK1 Taq1A and DRD2 C957T polymorphisms have limited if any effect on the performance on executive function tasks in healthy adults.

13. Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.

14. Fourteen healthy adult subjects underwent PET with [(18)F]fallypride, a radiotracer with strong affinity for DRD2, and fMRI (on a separate day) while performing a reward valuation task. [(18)F]fallypride binding potential, reflecting DRD2 availability, in the midbrain correlated positively with neural activity associated with expected value, specifically in the left ventral striatum/caudate.

15. Meta-analysis found that the minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking and higher plasma cotinine levels. This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent response during reward anticipation and with higher DRD2 gene expression in the striatum, but not with TTC12 or ANKK gene expression.

16. Perinatal hypoxia could influence neural development through different biological pathways depending on D2 receptor genotype.

17. Expression analysis indicated that miR-4301 was inversely correlated with DRD2 expression in breast cancer specimens. qRT-PCR showed that miR-4301 negatively regulated DRD2 expression. Downregulation of DRD2 expression in MDA-MB-231, MCF-7, and SKBR3 cells suppressed cell proliferation and promoted apoptosis.

18. Association studies of DRD2 receptor genes and schizophrenia have yielded varying results across different Indian populations.

19. In the presented study, one of selected polymorphisms of DRD2 gene, revealed to be correlated with substance use disorder (at the limit of statistical significance), which could suggest its impact on dependence endophenotype. The presented research was a pilot study, so it requires replication on a larger group of patients to verify and confirm obtained outcomes.

20. The rs6277 polymorphism in the DRD2 gene is an important variant that is thought to regulate D2 receptor availability in the striatum.

Cow (Bovine) Dopamine Receptor D2 (DRD2) Interaktionspartner

1. Studied a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to fescue toxicosis.

Mouse (Murine) Dopamine Receptor D2 (DRD2) Interaktionspartner

1. Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.

2. Suppressed proliferation and migration of mammary tumor cells chiefly by antagonizing dopamine receptor D2.

3. The authors show that genetic depletion of RGS9-2 mimics the D2 receptor loss of DYT1 dystonia striatum, whereas RGS9-2 overexpression rescues both receptor levels and electrophysiological responses in Dyt1 striatal neurons.

4. results suggest that the stimulation of D2R increases leptin production and may have a tissue-specific pro-inflammatory effect in adipocytes

5. The absence of the D2 dopamine receptor (D2R) increased impulsive behavior in mice, whereas restoration of D2R expression specifically in the central amygdala of D2R knockout mice normalized their enhanced impulsivity.

6. Drd2 signaling in the striatum alters the relationship between effort expenditure and extracellular dopamine.

7. Drd2 and Htr3a genes may play the key role in the synchronization of other genes of neurotransmitter systems in the ventral tegmental area of depressive male mice.

8. The reduction in goal-directed behavior is associated with dysfunction of D2R signaling via increased peripheral PYY.

9. The finding confirm the role of the dopamine D2 autoreceptors in reversal learning and suggest a broader involvement in behavioral inhibition mechanisms.

10. Results present evidence for the role of D2 dopamine receptors in structural alterations induced by the administration of the typical antipsychotic haloperidol and that chronic administration of clozapine has a limited influence on brain structure.

11. Impaired recruitment of dopamine neurons occurred during working memory in mice with striatal D2 receptor overexpression.

12. Findings show that loss-of-function of dopamine receptor type 2-expressing striatal medium spiny neurons (D2-MSNs) within ventrolateral striatum (VLS) is sufficient to reduce goal-directed behaviours.

13. Dopamine 2 receptor upregulation is associated with obesity.

14. D1/D2 medium spiny neurons in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease.

15. The present study evaluates the behavioral effects of pharmacological manipulation and genetic blockade of A2A R and D2 R within the frame of such a predominant striatal heteromeric population.

16. DRD2 in primary mesencephalic neurons had a significant regulative effect on the adipogenesis genes.

17. Dopamine D2 receptor deletion from parvalbumin interneurons in mouse causes an impaired inhibitory activity in the ventral hippocampus and a dysregulated dopaminergic system resulting in schizophrenia-like phenotypes.

18. boosting dopamine signaling in the striatum by acute cocaine administration reveals that absence of D2L, but not of D2S, strongly impairs the motor and cellular response to the drug, in a manner similar to the ablation of both isoforms. These results suggest that when the dopamine system is challenged, D2L signaling is required for the control of striatal circuits regulating motor activity.

19. These findings suggest the importance of Paraventricular Thalamus inhibition by D2Rs in modulating the sensitivity to cocaine, a finding that may have novel implications for human drug use.

20. This study explored the spatial distribution of D2 medium-sized spiny neurons across the rostral-caudal axis of the striatum using D2-eGFP double transgenic mice.

Rhesus Monkey Dopamine Receptor D2 (DRD2) Interaktionspartner

1. Study shows that blocking dopamine D1Rs or stimulating dopamine D2Rs increased low-frequency theta and alpha oscillations known to be involved in learning and memory. In contrast, only D1R inhibition enhanced high-frequency beta oscillations, whereas only D2R stimulation increased gamma oscillations linked to top-down and bottom-up attentional processing.

2. findings highlight complementary modulatory contributions of dopamine d1 & d2 receptors to the neuronal circuitry mediating executive functioning and goal-directed behavior.

3. Extrastriatal D2, D3, and D4 receptor activation in external pallidal segments also influences direct pathway elements in the basal ganglia under normal and parkinsonian conditions.

4. Mapped associations occur between changes in D2 and D3 dopamine receptor occupancy and brain hemodynamics

5. These data provide evidence for a predisposition to self-administer cocaine based on dopamine D2 receptor availability, and demonstrate that the brain dopamine system responds rapidly following cocaine exposure.

Horse (Equine) Dopamine Receptor D2 (DRD2) Interaktionspartner

1. The amount of dopamine d1 receptor, dopamine D2 receptor, and follicle stimulating hormone receptor mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.

Pig (Porcine) Dopamine Receptor D2 (DRD2) Interaktionspartner

1. The pig DRD2 gene was cloned, investigated its distribution in tissues and polymorphisms were identified.

2. The increase in NOS protein seen in both the endothelium and vascular smooth muscle in response to cerebral vasospasm is enhanced by dopamine in a D(2)R-dependent mechanism.

Fruit Fly (Drosophila melanogaster) Dopamine Receptor D2 (DRD2) Interaktionspartner

1. Damb receptor uniquely activates Gq to mobilize Ca(2+) signaling with greater efficiency and dopamine sensitivity

2. Findings suggest a role for dopamine D1-like receptor Dop1R2 in the repression of genes that coordinate metamorphosis.

3. Results suggest that the activation state of DAMB protein contributes to oxidative stress susceptibility in Drosophila and lead to a proposed model for paraquat neurotoxicity.

4. DD2R gene is expressed in the fat body, and its expression is higher in young females than in sexually mature females. The DD2R gene expression was not detected in ovarian follicular cells.

Guinea Pig Dopamine Receptor D2 (DRD2) Interaktionspartner

1. Dopamine D2 receptor play role in memory consolidation.