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Human CDK2 Protein expressed in Wheat germ - ABIN1348934
Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". in Molecular and cellular biology 2006
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CDK2 may have key functions in neuroblastoma (zeige ARHGEF16 Proteine) progression by regulating the expression of neoplastic genes.
The authors show that human Cyclin (zeige PCNA Proteine)-Dependent-Kinases (CDKs) target the RAD9 (zeige RAD9A Proteine) subunit of the 9-1-1 checkpoint clamp (zeige PDZK1 Proteine) on Thr292, to modulate DNA damage checkpoint activation. Thr292 phosphorylation on RAD9 (zeige RAD9A Proteine) creates a binding site for Polo-Like-Kinase1 (PLK1), which phosphorylates RAD9 (zeige RAD9A Proteine) on Thr313.
this study suggests that CDK2 and CDK9 (zeige CDK9 Proteine) are potential therapeutic targets in Neuroblastoma (zeige ARHGEF16 Proteine) (NB) and that abrogating CDK2 and CDK9 (zeige CDK9 Proteine) activity by small molecules like dinaciclib is a promising strategy and a treatment option for NB patients
LINC00958 acts as an oncogenic gene in the gliomagenesis through miR (zeige MLXIP Proteine)-203-CDK2 regulation, providing a novel insight into glioma tumorigenesis.
These compounds bind CDK2/ Cyclin A (zeige CCNA2 Proteine), inhibit its kinase activity, compete with substrate binding, but not with ATP, and dock onto the T-loop of CDK2. The best compound also binds CDK4 (zeige CDK4 Proteine) and CDK4 (zeige CDK4 Proteine)/Cyclin D1 (zeige CCND1 Proteine), but not CDK1 (zeige CDK1 Proteine).
CDK2 contributes to S81-AR phosphorylation and transactivation while CDK4 (zeige CDK4 Proteine) was not shown to be involved in this process.
Our findings provide a rationale for clinical use of Bcl-2 (zeige BCL2 Proteine) family inhibitors in combination with CDK2 inhibitors for treatment of Mcl-1 (zeige MCL1 Proteine)-dependent colorectal tumours associated with expression of Bcl-2 (zeige BCL2 Proteine), Bcl-XL (zeige BCL2L1 Proteine) and Bcl-w (zeige BCL2L2 Proteine) proteins. In addition, we have shown potential of CDK2 inhibitors for treatment of tumours expressing R273H mutant p53 (zeige TP53 Proteine).
Analysis of genomic data from TCGA demonstrated coamplification of CCNE1 (zeige CCNE1 Proteine) and AKT2 (zeige AKT2 Proteine) Overexpression of Cyclin E1 (zeige CCNE1 Proteine) and AKT (zeige AKT1 Proteine) isoforms, in addition to mutant TP53 (zeige TP53 Proteine), imparted malignant characteristics in untransformed fallopian tube secretory cells, the dominant site of origin of high-grade serous ovarian cancer
WHSC1L1 (zeige WHSC1L1 Proteine) and H3K36me2 are enriched in the gene bodies of the cell cycle-related genes CDC6 (zeige CDC6 Proteine) and CDK2, implying that WHSC1L1 (zeige WHSC1L1 Proteine) directly regulates the transcription of these gene
Findings suggest that ERK1/2-mediated Cdk2/cyclin A (zeige CCNA2 Proteine) signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
evidence that cyclin A1 (zeige CCNA1 Proteine)-associated activity is a mediator of apoptosis and that cyclin A1 (zeige CCNA1 Proteine)/Cdk2 is sufficient to induce apoptosis
Identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres.
CDK2 phosphorylates polyQ-AR specifically at Ser (zeige SIGLEC1 Proteine)(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 activity.
CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals
Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (zeige CCNE1 Proteine)/cdk2 promoting hepatocarcinogenesis.
This approach allowed us to determine the identity of cyclin E (zeige CCNE1 Proteine) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (zeige PCNA Proteine) E1and cyclin E2 (zeige CCNE2 Proteine))and its associated kinase, Cdk2, in different mouse organs.
RingoA (zeige SPDYA Proteine) is an important activator of Cdk2 at meiotic telomeres.
Foxo3 (zeige FOXO3 Proteine) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21 (zeige CDKN1A Proteine), PCNA (zeige PCNA Proteine) and cdk2, but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.
PI3-kinase (zeige PIK3CA Proteine) and Akt (zeige AKT1 Proteine) participate in insulin (zeige INS Proteine) stimulation of p34cdc2 (zeige CDK1 Proteine) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.
an essential role for UHRF1 (zeige UHRF1 Proteine) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (zeige CCNA2 Proteine) during early vertebrate development
cyclin D1 (zeige CCND1 Proteine), CDK2 and CDK4 (zeige CDK4 Proteine) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
our results indicate that an ATM (zeige ATM Proteine)-P53 (zeige TP53 Proteine)-P21 (zeige CDKN1A Proteine) DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, Cyclin-dependent kinase 2-interacting protein
, cyclin-dependent kinase 2 interacting protein
, cyclin-dependent kinase 2-interacting protein
, MGC84068 protein
, cyclin dependent kinase 2-alpha
, cyclin-dependent kinase 2
, CDC2 homolog Eg1 protein kinase
, Cell division protein kinase 2