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Human Polyclonal AKT3 Primary Antibody für DB - ABIN389853
Huang, Gonzalez, Toy, Banerjee, Kleer: Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. in Cancer research 2010
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Human Polyclonal AKT3 Primary Antibody für ICC, IF - ABIN4279075
Vredeveld, Possik, Smit, Meissl, Michaloglou, Horlings, Ajouaou, Kortman, Dankort, McMahon, Mooi, Peeper: Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. in Genes & development 2012
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Human Monoclonal AKT3 Primary Antibody für ELISA, WB - ABIN968952
Easton, Cho, Roovers, Shineman, Mizrahi, Forman, Lee, Szabolcs, de Jong, Oltersdorf, Ludwig, Efstratiadis, Birnbaum: Role for Akt3/protein kinase Bgamma in attainment of normal brain size. in Molecular and cellular biology 2005
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Human Monoclonal AKT3 Primary Antibody für ELISA, WB - ABIN965532
Stahl, Sharma, Cheung, Zimmerman, Cheng, Bosenberg, Kester, Sandirasegarane, Robertson: Deregulated Akt3 activity promotes development of malignant melanoma. in Cancer research 2004
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Human Polyclonal AKT3 Primary Antibody für ELISA, WB - ABIN250324
Zinda, Johnson, Paul, Horn, Konicek, Lu, Sandusky, Thomas, Neubauer, Lai, Graff: AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon. in Clinical cancer research : an official journal of the American Association for Cancer Research 2001
Human Monoclonal AKT3 Primary Antibody für FACS, IF - ABIN2715859
Veillette, Grenier, Brasseur, Fréchette-Frigon, Leblanc, Parent, Asselin: Regulation of the PI3-K/Akt survival pathway in the rat endometrium. in Biology of reproduction 2013
Human Monoclonal AKT3 Primary Antibody für IHC, ELISA - ABIN1043749
Bogen, Jensen, Hvalby, Walaas: Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse. in Seminars in cell & developmental biology 2011
miR (zeige MLXIP Antikörper)-30a-3p may be a promising biomarker for the early screening of high-risk populations and early diagnosis of Lung adenocarcinoma (LUAD). Our studies provide insights into identifying novel potential biomarkers for diagnosis and prognosis of LUAD
these findings illustrated that cir (zeige KCNJ5 Antikörper)-ZNF609 (zeige ZNF609 Antikörper) took part in the onset of HSCR (zeige EDNRB Antikörper) through the crosstalk with AKT3 by competing for shared miR (zeige MLXIP Antikörper)-150-5p.
Results found that TR4 (zeige NR2C2 Antikörper) promotes the AKT3 expression through transcriptional regulation to drive the EMT (zeige ITK Antikörper) phenotype and enhance the seminoma cell proliferation and invasion.
Akt1 (zeige AKT1 Antikörper)-Akt3 activity (according to Thr308 phosphorylation) is not associated with proliferative processes in the tumor tissue of the thyroid.
The results of this study indicated AKT (zeige AKT1 Antikörper) isoforms have different roles and downstream substrates in glioblastoma. and they indicate AKT3 delays tumor progression.
Report frequency of genetic variation in Akt3 and discuss link to disease.
AKT3 Splice Variants are associated with HPV-Positive Oropharyngeal Cancers.
Results show that AKT3 influences outcome of pneumococcal meningitis in human patients; validated the findings in a mouse experimental pneumococcal meningitis model.
High AKT3 expression is associated with triple-negative breast cancer.
This study showed that activating mutations of AKT3 are associated with a much broader spectrum of developmental brain disorders in children, with several clinical phenotypes determined partially by the type of mutation and level of mosaicism.
The authors find in Mus (zeige TRPV6 Antikörper) musculus, each AKT (zeige AKT1 Antikörper) isoform has a unique expression pattern in the hippocampus. AKT1 (zeige AKT1 Antikörper), but not AKT2 (zeige AKT2 Antikörper) or AKT3, is required for late long term potetiation (LTD) through regulating activity-induced protein synthesis. Interestingly, AKT (zeige AKT1 Antikörper) activity inhibits mGluR (zeige GRM8 Antikörper)-LTD, with overlapping functions for AKT1 (zeige AKT1 Antikörper) and AKT3.
Behavioral data on Akt3-/- and Akt1 (zeige AKT1 Antikörper)-/- mice demonstrated that Akt3 but not Akt1 (zeige AKT1 Antikörper) is required for spatial learning. Histological analyses on synapse, dendrite, and myelin markers suggested that Akt3 but not Akt1 (zeige AKT1 Antikörper) is important for the white matter integrity, and that Akt (zeige AKT1 Antikörper) single isoform does not play a pivotal role on neuronal survival.
findings provide novel insight into the neurodevelopmental role of Akt3, identify a non-redundant role for Akt3 in the development of prefrontal cortical-mediated cognitive function and show that Akt3 is potentially the dominant regulator of AKT (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling in brain
these results indicate that PI3K and Akt ( Akt1 (zeige AKT1 Antikörper)-Akt3)play distinct roles, and that PI3K stimulates Akt (zeige AKT1 Antikörper)-independent pathways that are important for GLUT4 (zeige SLC2A4 Antikörper) translocation.
miR (zeige MLXIP Antikörper)-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway.
Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (zeige WNK1 Antikörper)/SGK1 (zeige SGK1 Antikörper)/Cdc42 (zeige CDC42 Antikörper) pathway.
The predominant AKT (zeige AKT1 Antikörper) isoform in the central nervous system, AKT3, induces much more robust axon regeneration than AKT1 (zeige AKT1 Antikörper) and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT (zeige AKT1 Antikörper)-induced axon regeneration.
Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4 (zeige S100A4 Antikörper).
In viable Akt (zeige AKT1 Antikörper) three-isoforms conditional knockout mice, total Akt (zeige AKT1 Antikörper) levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt3-/-)mice.
These findings are important because Wnt (zeige WNT2 Antikörper), BMPR2 (zeige BMPR2 Antikörper), and Akt3 promote neurogenesis and cell survival, processes crucial for lifelong viral latency.
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
, RAC-gamma serine/threonine protein kinase
, RAC-gamma serine/threonine-protein kinase
, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
, protein kinase Akt-3
, protein kinase B gamma
, AKT3 kinase
, protein kinase B, gamma
, thymoma viral proto-oncogene 3
, v-akt murine thymoma viral oncogene 3
, protein kinase B gamma-like protein
, v-akt murine thymoma viral oncogene-like 3
, LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase