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anti-Human AKT3 Antikörper:
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Human Polyclonal AKT3 Primary Antibody für DB - ABIN389853
Huang, Gonzalez, Toy, Banerjee, Kleer: Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. in Cancer research 2010
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Human Polyclonal AKT3 Primary Antibody für ICC, IF - ABIN4279075
Vredeveld, Possik, Smit, Meissl, Michaloglou, Horlings, Ajouaou, Kortman, Dankort, McMahon, Mooi, Peeper: Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. in Genes & development 2012
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Human Monoclonal AKT3 Primary Antibody für ELISA, WB - ABIN968952
Easton, Cho, Roovers, Shineman, Mizrahi, Forman, Lee, Szabolcs, de Jong, Oltersdorf, Ludwig, Efstratiadis, Birnbaum: Role for Akt3/protein kinase Bgamma in attainment of normal brain size. in Molecular and cellular biology 2005
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Human Monoclonal AKT3 Primary Antibody für ELISA, WB - ABIN965532
Stahl, Sharma, Cheung, Zimmerman, Cheng, Bosenberg, Kester, Sandirasegarane, Robertson: Deregulated Akt3 activity promotes development of malignant melanoma. in Cancer research 2004
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Human Polyclonal AKT3 Primary Antibody für ELISA, WB - ABIN250324
Zinda, Johnson, Paul, Horn, Konicek, Lu, Sandusky, Thomas, Neubauer, Lai, Graff: AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon. in Clinical cancer research : an official journal of the American Association for Cancer Research 2001
Human Monoclonal AKT3 Primary Antibody für FACS, IF - ABIN2452528
Veillette, Grenier, Brasseur, Fréchette-Frigon, Leblanc, Parent, Asselin: Regulation of the PI3-K/Akt survival pathway in the rat endometrium. in Biology of reproduction 2013
Human Monoclonal AKT3 Primary Antibody für IHC, ELISA - ABIN1043749
Bogen, Jensen, Hvalby, Walaas: Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse. in Seminars in cell & developmental biology 2011
Report frequency of genetic variation in Akt3 and discuss link to disease.
AKT3 Splice Variants are associated with HPV-Positive Oropharyngeal Cancers.
Results show that AKT3 influences outcome of pneumococcal meningitis in human patients; validated the findings in a mouse experimental pneumococcal meningitis model.
High AKT3 expression is associated with triple-negative breast cancer.
This study showed that activating mutations of AKT3 are associated with a much broader spectrum of developmental brain disorders in children, with several clinical phenotypes determined partially by the type of mutation and level of mosaicism.
MiR (zeige MLXIP Antikörper)-511-3p may serve as a prognostic factor and tumor suppressor in prostate cancer, very likely through inverse regulation of its downstream target gene of AKT3.
Studies found AKT3 to be important in coordinating mitochondrial biogenesis with growth factor-induced increase in cellular energy demands. This isoform also plays an important role in platelet activation and thrombosis. [review]
miR (zeige MLXIP Antikörper)-29b prevents angiogenesis/tumorigenesis in breast cancer cell by targeting Akt3 and inducing VEGF (zeige VEGFA Antikörper) and C-myc (zeige MYC Antikörper) arrest in breast cancer cells.
AKT3 expression is markedly upregulated in AKT (zeige AKT1 Antikörper) inhibitor-resistant cells. Induction of AKT3 is regulated epigenetically by the bromodomain and extra terminal domain proteins. Importantly, knockdown of AKT3, but not AKT1 (zeige AKT1 Antikörper) or AKT2 (zeige AKT2 Antikörper), in resistant cells restores sensitivity to MK2206.
miR (zeige MLXIP Antikörper)-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway.
findings provide novel insight into the neurodevelopmental role of Akt3, identify a non-redundant role for Akt3 in the development of prefrontal cortical-mediated cognitive function and show that Akt3 is potentially the dominant regulator of AKT (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling in brain
these results indicate that PI3K and Akt ( Akt1 (zeige AKT1 Antikörper)-Akt3)play distinct roles, and that PI3K stimulates Akt (zeige AKT1 Antikörper)-independent pathways that are important for GLUT4 (zeige SLC2A4 Antikörper) translocation.
Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (zeige WNK1 Antikörper)/SGK1 (zeige SGK1 Antikörper)/Cdc42 (zeige CDC42 Antikörper) pathway.
The predominant AKT (zeige AKT1 Antikörper) isoform in the central nervous system, AKT3, induces much more robust axon regeneration than AKT1 (zeige AKT1 Antikörper) and that activation of mTORC1 and inhibition of GSK3beta (zeige GSK3b Antikörper) are two critical parallel pathways for AKT (zeige AKT1 Antikörper)-induced axon regeneration.
Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4 (zeige S100A4 Antikörper).
In viable Akt (zeige AKT1 Antikörper) three-isoforms conditional knockout mice, total Akt (zeige AKT1 Antikörper) levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt3-/-)mice.
untreated Akt1 (zeige AKT1 Antikörper) and Akt2 (zeige AKT2 Antikörper)/Akt3 double knockout mice display significant hearing loss, indicating a role for these isoforms in normal hearing.
MicroRNA-207 enhances radiation-induced apoptosis by targeting Akt3 in cochlea hair cells.
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
, RAC-gamma serine/threonine protein kinase
, RAC-gamma serine/threonine-protein kinase
, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
, protein kinase Akt-3
, protein kinase B gamma
, AKT3 kinase
, protein kinase B, gamma
, thymoma viral proto-oncogene 3
, v-akt murine thymoma viral oncogene 3
, protein kinase B gamma-like protein
, v-akt murine thymoma viral oncogene-like 3
, LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase