Vitamin D Receptor (VDR) (N-Term) Peptid
VDR
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN986049
Kurzübersicht für Vitamin D Receptor (VDR) (N-Term) Peptid (ABIN986049)
Target
Vitamin D Receptor (VDR)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-VDR antibody (Catalog #: P100895_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Vitamin D Receptor (VDR) peptide
VDR Reaktivität: Human, Maus, Ratte, Hund Wirt: Synthetic BP, Imm
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Vitamin D Receptor (VDR)
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Substanzklasse
- Chemical
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Hintergrund
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VDR is the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Thus, alternative splicing results and multiple transcript variants encoding the same protein appears. This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: NR1I1
Protein Interaction Partner: CDK7,GTF2B,KDM5A,NCOA1,NCOA2,NCOA3,RXRA,SMAD3,ACVR1,BAG1,CCND3,CDK7,CREBBP,CSNK2A1,FGR,GABARAPL1,GABARAPL2,GTF2B,HMGN3,HR,JUN,KDM5A,MED1,NCOA1,NCOA2,NCOA6,NR0B2,NR1H2,NRIP1,PPP1CA,PPP2CA,PSMC5,RXRA,RXRB,RXRG,SMAD3,SNW1,SNW1,STAT1,TDG,TRIM24,VDR,ZBTB16,BAG1,BAZ1B,FOS,JUN,KDM5A,MED1,MED12,MED13,MED14,MED16,MED21,MED24,MED6,NCOA2,NCOA3,NCOR1,NCOR2,Ncoa2,POU1F1,POU2F1,RB1,RUNX1,RUNX1T1,RXRA,SMARCA4,SNW1,STAT1,TDG,THRAP3,TRRAP,VDR,ZBTB16
Protein Size: 427 -
Molekulargewicht
- 48 kDa
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Gen-ID
- 7421
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NCBI Accession
- NM_000376, NP_000367
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UniProt
- P11473
Target
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