PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. PDZK1 may play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 may potentiate the CFTR chloride channel activity. It may function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. PDZK1 may be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
Alias Symbols: CAP70, CLAMP, NHERF3, PDZD1, NHERF-3
Protein Interaction Partner: ABCA1,ABCC2,AKAP10,CFTR,CLCN3,GFAP,PDZK1IP1,PEX5,SCARB1,SLC15A2,SLC17A1,SLC22A11,SLC22A12,SLC22A4,SLC22A5,SLC26A6,SLC9A3,SLCO1A2,SSTR5,ABCC2,AKAP10,CFTR,CLCN3,FARP2,GFAP,PDZK1IP1,PEX5,SCARB1,SLC17A1,SLC22A12,SLC22A4,SLC34A3,SLC9A3,SLC9A3R1,SLC9A3R2,SLK,UBE2I
Protein Size: 370