TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (N-Term) Peptid

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Proteinname
  • 3'-Tab1
  • MAP3K7IP1
  • 2310012M03Rik
  • Map3k7ip1
  • b2b449Clo
  • TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • TAB1
  • Tab1
Protein Region
N-Term
Spezies
Human
3
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
Hersteller
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Geblockter Antikörper anti-TAB1 Antikörper (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1) (N-Term) (ABIN2785275)
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-MAP3K7IP1 antibody (Catalog #: ARP53182_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Hintergrund The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alias Symbols: 3'-Tab1, MGC57664, TAB1, MAP3K7IP1

Protein Interaction Partner: MAP3K7,MAPK14,XIAP,BMPR1A,MAP3K7,MAPK11,MAPK14,NR2C2,SMAD6,SMAD7,TAB2,TAB3,TRAF2,TRAF6,XIAP,YWHAG,MAP3K7,MAPK14,Rrp1b,SMAD6,SMAD7,TAB2,TAB3,TRAF2,TRAF6,XIAP,ZMYND11

Protein Size: 462
Molekulargewicht 50 kDa
Gen-ID 10454
NCBI Accession NM_153497, NP_705717
UniProt Q8IZW2
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.