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Human PAX6 Protein expressed in Wheat germ - ABIN1314075
Maucksch, Firmin, Butler-Munro, Montgomery, Dottori, Connor: Non-Viral Generation of Neural Precursor-like Cells from Adult Human Fibroblasts. in Journal of stem cells & regenerative medicine 2014
SHH (zeige SHH Proteine)-dependent E-ligase Midline1 (zeige MID1 Proteine) regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development.
signaling via Pax6 expression through Shp2-binding sites of XFrs3 is necessary for the eye development in Xenopus laevis
Our results show that the expression of Pax6 and Pax7 (zeige PAX7 Proteine) is widely maintained in the adult brain of Xenopus
This study revealed an outstanding mutation pattern in non-coding PAX6 regions confirming that PAX6 remains the major gene for aniridia.
This is the first report on the mutational spectrum of PAX6 in aniridia patients of Cypriot ancestry.
Deletions of the 3 ' regulatory regions downstream of paired box protein (PAX6) abrogate its expression leading to aniridia due to PAX6 haploinsufficiency in a 44-year-old mother and her 13-year-old son.
The results demonstrated that miR874 may serve tumor suppressive roles in pancreatic ductal adenocarcinoma (PDAC) by directly targeting PAX6. Therefore, miR874 may exhibit potential applications for treatment of patients with PDAC.
PAX6 was upregulated in Colorectal cancer tissues and was negatively correlated with miR383 expression.
PAX6 knockdown recapitulated effects similar to those observed following miR (zeige MLXIP Proteine)-655 overexpression regarding the proliferation, invasion and apoptosis of retinoblastoma (RB)cells. Rescue experiments demonstrated that restoration of PAX6 expression reversed the tumour-suppressing roles of miR (zeige MLXIP Proteine)-655 in RB cells
excessive PAX6 expression in insulin (zeige INS Proteine)-challenged endometrial epithelial cells may contribute to the uncontrollable endometrial epithelial proliferation in polycystic ovarian syndrome
overexpression of CHD1L (zeige CHD1L Proteine) in embryonic cells upregulated the expression of ectoderm genes, especially PAX6
PAX6 mutations explained 96.7% of aniridia phenotypes in this study with only 3 of 91 probands lacking pathogenic variants in the gene.
Mutation screening of PAX6 gene helped in identifying a novel heterozygous pathogenic variation g. 31801757dupG (c. 216-19dupG) that resulted in a frameshift mutation that extended into exon 7.
Some polymorphisms in PAX6 are associated with growth traits at some ages, and may be used as candidates for marker-assisted selection in beef cattle breeding program.
a novel regulatory relationship between the retinal pigmented epithelium (RPE (zeige RPE Proteine)) transcription factors Pax6 and Sox9 (zeige SOX9 Proteine) that controls the timing of RPE (zeige RPE Proteine) differentiation and the adjacent choroid maturation, is reported.
PAX6 can substitute for LHX2 (zeige LHX2 Proteine) and override NFIA (zeige NFIA Proteine)-induced astrogliogenesis in developing hippocampus in vivo.
these results not only reveal a novel function for LHX2 (zeige LHX2 Proteine) in regulating dorsoventral patterning in the telencephalon, but also identify PAX6 as a fundamental regulator of where the hem can form, and therefore implicate this molecule as a determinant of hippocampal positioning.
Comparative functional analyses revealed that the neurogenic function of Pax6 is highly conserved in the developing mouse and chick pallium, whereas stage-specific binary functions of Pax6 in neurogenesis are unique to mouse neuronal progenitors, consistent with Pax6-dependent temporal regulation of Notch (zeige NOTCH1 Proteine) signaling. Pax6-dependent enhancer activity of Dbx1 (zeige DBX1 Proteine) is extensively conserved between mammals and chick.
These results demonstrate a novel role for Tlx3 (zeige TLX3 Proteine) and indicate that Pax6-Tlx3 (zeige TLX3 Proteine) expression and interaction is part of a region specific regulatory network in cerebellum and its deregulation during development could possibly lead to Autistic spectral disorders (ASD (zeige GUSB Proteine)).
Pax6 (and IBA1 (zeige AIF1 Proteine)) co-localize in the brain and also interact physically.
Pax6 normally represses Cdca7 (zeige CDCA7 Proteine) expression in the lateral cortex and that repression of Cdca7 (zeige CDCA7 Proteine) in cells of this region is required for their production of a normal complement of Tbr2 (zeige EOMES Proteine)-expressing intermediate progenitors
this Pax6 (fl) allele provides a useful addition to the existing Pax6 allelic series and this study demonstrates the utility of using compound heterozygotes with null alleles to unmask cryptic effects of floxed alleles.
Data show that Pax6 acts in RPCs to control differentiation of multiple late-born neuronal cell types.
Study finds that Pax6 is initially distributed contiguously throughout a large domain of the anterior neural plate of zebrafish, including the presumptive eye fields and the dorsal diencephalon. After evagination of the optic vesicle, Pax6 becomes restricted to all proliferating cells of the pigment epithelial and neural layers of the retina.
Pax6 has an evolutionarily conserved function in establishing the temporospatial expression of Shh (zeige SHH Proteine) in the mid-diencephalic organizer in vertebrates.
loss of Pax6b or Hb9 (zeige MNX1 Proteine) independently results in the loss of insulin (zeige INS Proteine) expression, the data reveal a novel cross-talk between the two essential regulators of early beta-cell differentiation.
The results suggest that decreased Pax6 expression is permissive for axon regeneration and extensive searching, while higher levels of Pax6 are associated with restoration of topography.
This study supports the hypothesis that the Pax6 transcription factor is also a signaling molecule with direct non-cell autonomous activity.
following a postulated whole-genome duplication event in an ancestral teleost, duplicates pax6a and pax6b encode transcription factors required for eye, brain, olfactory system, and pancreas development
Pax6 interacts with itself via both the paired domain and the homeodomain. Pax6 interaction with itself superactivates Pax6 mediated transactivation.
This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
paired box protein Pax-6
, paired box 6
, paired box gene 6
, paired box homeotic gene 6
, paired box gene 6 a
, aniridia type II protein
, paired box homeotic gene-6
, paired box gene 6 (aniridia, keratitis)
, paired box protein PAX6
, paired box gene 6 b
, paired domain transcription factor variant B
, paired-type homeodomain Pax-6 protein
, Dickie's small eye
, small eye
, paired box protein Pax[Zf-a]