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This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.
SCY1 family protein kinase
, N-terminal kinase-like protein
, SCY1-like 1 (S. cerevisiae)
, n-terminal kinase-like protein-like
, SCY1-like protein 1
, coated vesicle-associated kinase of 90 kDa
, likely ortholog of mouse N-terminal kinase-like protein
, telomerase regulation-associated protein
, telomerase transcriptional element-interacting factor
, telomerase transcriptional elements-interacting factor
, teratoma-associated tyrosine kinase
, 105 kDa kinase-like protein
, SCY1-like 1 splice variant 13
, SCY1-like 1 splice variant 15
, mitosis-associated kinase-like protein NTKL
, ubiquitous protein kinase-like (105 kDa)