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Studies suggest that the rs2718058 near gene NME8 on chromosome 7p14.1 might not play a major role in the genetic predisposition to late-onset Alzheimer's disease (LOAD) in the North Han Chinese.
Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, DSST, and WFT, respectively, in whites.
NME8 locus polymorphism is associated with cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease.
GPR141-NME8 locus had strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with history of smoking. identified 2 suggestive loci for periodontitis in a Japanese population.
Our approach yielded 26 candidate genes differentially expressed between patients (Osteoarthritis) and controls. The presence of allelic imbalances confirms cis-regulatory mechanisms for RHOB and TXNDC3.
genetic association of RHOB and TXNDC3 with osteoarthritis was detected
Primary ciliary dyskinesia is caused by an SNP-induced modification of the ratio of two physiological isoforms of TXNDC3 generated by alternative splicing.
The minor allele frequencies of TXNDC3 in East Asian individuals are significantly different from those in United Kingdom control individuals.
Txndc2 and Txndc3 are critically important in protecting spermatozoa against the increases in oxidative stress associated with paternal age.
data indicate that spermatid-specific thioredoxin-2 incorporation into the sperm fibrous sheath(FS) lags well behind FS assembly, suggesting it is required during the final stages of sperm tail maturation
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.
sperm-specific thioredoxin 2
, spermatid-specific thioredoxin-2
, thioredoxin domain containing 3 (spermatozoa)
, thioredoxin domain-containing protein 3
, spermatid-specific thioredoxin-2 protein