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anti-Mouse (Murine) Vitamin D Receptor Antikörper:
anti-Rat (Rattus) Vitamin D Receptor Antikörper:
anti-Human Vitamin D Receptor Antikörper:
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Chemical Polyclonal Vitamin D Receptor Primary Antibody für IF (p), IHC (p) - ABIN682513
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. in International journal of clinical and experimental pathology 2014
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Chemical Polyclonal Vitamin D Receptor Primary Antibody für IHC (p), WB - ABIN3043960
Gao, Wang, Yan, Zeng, Ma, Niu, Zhou, Jiang, Chen: Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats. in PLoS ONE 2016
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Chemical Polyclonal Vitamin D Receptor Primary Antibody für WB - ABIN3042969
Hou, Huang, Luo, Wang, Liu, Deng, Zhang, Liu, Chen: MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR. in American journal of translational research 2017
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Dog (Canine) Polyclonal Vitamin D Receptor Primary Antibody für ELISA, WB - ABIN547464
Malerba, Pignatti: A review of asthma genetics: gene expression studies and recent candidates. in Journal of applied genetics 2005
Human Monoclonal Vitamin D Receptor Primary Antibody für DB, WB - ABIN4251062
Momen-Heravi, Masugi, Qian, Nishihara, Liu, Smith-Warner, Keum, Zhang, Tchrakian, Nowak, Yang, Ma, Bowden, da Silva, Wang, Fuchs, Meyerhardt, Ng, Wu, Giovannucci, Ogino, Zhang: Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study. in International journal of cancer 2017
Chemical Polyclonal Vitamin D Receptor Primary Antibody für ELISA, WB - ABIN2477107
Cheng, Chen, Huang, Chang, Hung: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. in Journal of cellular biochemistry 2006
Chemical Monoclonal Vitamin D Receptor Primary Antibody für IHC (p) - ABIN2477108
Ditsch, Toth, Mayr, Lenhard, Gallwas, Weissenbacher, Dannecker, Friese, Jeschke: The association between vitamin D receptor expression and prolonged overall survival in breast cancer. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012
Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
zebrafish embryos lacking vdrb produced fewer sensory hair cells in the ears and showed disruption of balance and motor coordination.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
investigation of binding of ligands that induce significant conformational changes at the protein level
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
Mice with VDR-deficiency showed spontaneous myocarditis that was characterized as the Th2-biased inflammation.
VDR binds NLRP3 to restrict IL4 gene transcription and prevent biased Th2 polarization.
Vitamin D Receptor in Energy Metabolism Revealed by Profiling of Lysine Succinylome of White Adipose Tissue
Recent studies suggest that in in inflammatory bowel diseases the association of VDR single nucleotide polymorphisms with immune and intestinal pathology may be sex dependent. [review]
While further studies are required to determine the mechanisms, by which vitamin D activity regulates osteoclastic bone resorption, our findings suggest that VDR-mediated activity in mature osteoclasts is required to moderate osteoclastic activity during growth and in ovariectomy-induced bone loss.
Our data indicate abnormal osteoclastogenesis due to the absence of Vdr expression, consistent with direct effects of vitamin D signalling being important for regulating the maturation and resorptive activities of osteoclasts.
We conclude that the relative VDR level and the 1,25D availability to cells, are important co-determinants for whether 1,25D plays a promoting or suppressive role in osteoblast-mediated osteogenic activity.
Taken together, our in vivo studies using ChIP-seq analyses and the mini-gene transgenic mice improve our understanding of the tissue-specific regulatory mechanisms of controlling VDR expression and the mechanisms of action of the VDR.
Low VDR expression is associated with epithelial-mesenchymal transition and metastasis in breast cancer.
These findings suggest that Vdr has a cell-intrinsic function in early erythroid progenitors.
Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
The elevated levels of miR-351 promoted hepatic fibrosis by targeting the vitamin D receptor (VDR), which is an antagonist of SMAD signaling.
the crucial role of VDR in anti-inflammatory effects in lungs
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.
Data suggest that the absence of VDR inhibits atherosclerotic plaque calcification in hypercholesterolemic Apoe(-/-) mice, providing additional insight into the role of vitamin D in atherosclerotic plaque calcification.
Lower expression of VDR, high frequency of Th2 cells and increase in Th2 cytokines occur in the hearts of patients with myocarditis at the end stage of heart failure.
ApaI-polymorphism of the VDR gene is associated with the development of generalized periodontitis in the Ukrainian population
Decreased placental VDR expression contributes to altered expression of TGFbeta3 in fetal growth restriction (FGR), suggesting a mechanistic pathway by which decreased placental VDR expression may contribute to abberant cell-cycle regulation thereby reducing the feto-placental growth in human idiopathic FGR.
1a,25(OH)2D3 restrains the stem celllike properties of ovarian cancer cells by enhancing the expression of VDR, by promoting the expression of betacatenin in the cytoplasm, and by suppressing the expression of CD44. These findings provide a novel insight into the functions of vitamin D in diminishing the stemness of cancer cancer stem celllike cells (CSCs).
High VDR expression is associated with Nonalcoholic Fatty Liver Pathogenesis.
VDR genetic polymorphism may be correlated to lung cancer risk (Meta-Analysis)
Findings demonstrated that VDR ApaI (rs7975232) and VDR BsmI (rs1544410) polymorphisms are correlated with susceptibility to polycystic ovary syndrome (PCOS) in the Asian population; but no association was found for VDR TaqI (rs731236), VDR FokI (rs2228570), and VDR Tru9I (rs757343) with the PCOS susceptibility.
Polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites.
Linear regression analysis showed the mediatory role of VDR and PGC-1alpha on the Resting metabolic rate (RMR)/kg body weight and vitamin D status relationship among obese individuals. Results showed that VDR had a mediatory effect on the relationship between RMR/kg body weight and vitamin D status. However, PGC-1alpha did not affect the relationship between RMR/kg body weight and vitamin D status.
The BsmI AG genotype was more frequent in polycystic ovary syndrome (PCOS) group, while the GG genotype was more frequent in the control group. The frequency of the Taql CC genotype was higher in PCOS group, while the CT genotype was the most frequent in the control group.
Displacement of VDR was significantly correlated with lower histological grade. Clinicians might be able to predict prognosis and decide therapies related to vitamin D analogs using this remarkable biomarker for endometrial carcinoma.
rs2228570, rs3847987, rs2189480, and rs2239179 variants significantly associated with metabolic syndrome in rural population of Henan province in China
Alternative splicing of the class II VDR can also generate ligand-independent isoforms of the receptor capable of modulating target gene expression.
Data obtained suggested that the VDR variants play an important role in regulating adipose tissue activity and adiposity among Han Chinese.
Donor/recipient CYP27A1 rs4674344 and graft VDR rs2228570 may be related to low serum 25(OH)D and may play a major role in the development of fatty liver disease in recipients after living donor liver transplantation.
Study provides evidence that VDR polymorphisms are associated with upper urinary tract stones incidence. [meta-analysis]
Automobile paints workers with ALAD 1-2 genotype showed the positive association of blood lead levels with diastolic blood pressure whereas, a genotypic combination of ALAD 1-2/VDR BB showed the negative association of serum uric acid with BLL.
Variants in the VDR gene were associated with the variability in response to warfarin, emphasizing the possible clinical relevance of nuclear receptor gene variants on the inter-individual variability in drug metabolism.
The study found that Crohn's disease patients who were homozygous for the risk allele presented lower levels of VDR protein in peripheral blood mononuclear cells (PBMCs), and this was associated with an upregulation of IL1beta mRNA and activation of lymphocytic adhesion molecules.
The down-regulation of VDR expression in renal tissues of Lupus Nephritis patients was negatively correlated with renal activity and injury severity.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein