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We found that the thyroid hormone receptor (TRalpha 3) has a differential expression profile. Thyroid hormone (zeige PTH Proteine) is critical for normal brain development. Our results showed that there is a possible link between IGF1 (zeige IGF1 Proteine)/IGF1R (zeige IGF1R Proteine) and the TRalpha 3 and that over expression of IGF1R (zeige IGF1R Proteine) in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons.
Downregulation of NR1D1 (zeige NR1D1 Proteine) in MCF7 cells resulted in resistance to doxorubicin, both in vitro and in vivo Analysis of four public patient data sets indicated that NR1D1 (zeige NR1D1 Proteine) expression correlates positively with clinical outcome in breast cancer patients who received chemotherapy. Our findings suggest that NR1D1 (zeige NR1D1 Proteine) and its ligands provide therapeutic options that could enhance the outcomes of chemotherapy in breast cancer patients
THRA predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB (zeige THRB Proteine) is expressed at lower levels and is upregulated during hADSC differentiation.
Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha (zeige NR1D1 Proteine) specificity for the NCoR (zeige NCOR1 Proteine) corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR (zeige NCOR1 Proteine).
8 different THRA gene abnormalities have been described in 14 patients from 9 families with phenotypes including short stature, dysmorphic syndrome, psychoneuromotor disorders, constipation and bradycardia. Review.
Data show that ubiquitin E3 ligase Siah2 (zeige SIAH2 Proteine) depletion delays circadian degradation of nuclear hormone receptor (zeige NR0B1 Proteine) RevErbalpha (Nr1d1 (zeige NR1D1 Proteine)) and lengthens period length.
The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases.
the role of NR1D1 (zeige NR1D1 Proteine) polymorphisms in the regulation of Nuclear receptor REV-ERBalpha (zeige NR1D1 Proteine) and circadian rhythms regulation
associations between NR1D1 (zeige NR1D1 Proteine), RORA (zeige RORA Proteine) and RORB (zeige RORB Proteine) genes and bipolar disorder.(
CRY2 (zeige CRY2 Proteine) and REV-ERB ALPHA (zeige NR1D1 Proteine) as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA (zeige NR1D1 Proteine) is an important gene associated with MS.
the Gata-1 (zeige GATA1 Proteine) gene was a T3-directly regulated gene and that TRa1PV could impair erythropoiesis via repression of the Gata-1 (zeige GATA1 Proteine) gene and its regulated genes. These results provide new insights into how TRa1 (zeige HSP90B1 Proteine) mutants acted to cause erythroid abnormalities in patients with mutations of the THRA gene.
Using domain exchanges and individual amino acid switches between THRA1 and THRB2 (zeige THRB Proteine), three amino acids were identified in helix 10 of the THRB2 (zeige THRB Proteine) ligand-binding domain that are required for negative regulation and are absent in THRA1.
Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh (zeige IHH Proteine) gene.
Hippocampal transcriptome profile of persistent memory rescue in a mouse model of Thra1 mutation-mediated resistance to thyroid hormone (zeige PTH Proteine) has been reported.
deletion of TRalpha (zeige GNAT1 Proteine) in ApoE (zeige APOE Proteine)(-/-) mice alters cardiac structure and contractility; both could contribute to blunted BP response to physical exercise and impaired exercise performance
Data (including data from studies in knockout mice) suggest mitochondrial T3Ralpha in brown adipose tissue is key to regulation of energy metabolism; knockout mice exhibit hypermetabolism/hyperphagia, but not cold intolerance/defective thermogenesis.
Data (including data from studies in mutant strains of mice) suggest Thra1 (but not Thrb (zeige THRB Proteine)) plays role in myogenesis, cell proliferation, and resistance to T3 (triiodothyronine) in skeletal myoblasts; Thra1 promotes muscle regeneration after injury.
In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad (zeige SMAD1 Proteine) signaling.
regions of the Xenopus and mouse Klf9 (zeige KLF9 Proteine) genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC.
Data show that TRbeta (zeige THRB Proteine) deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process.
Data provide evidence that zebrafish represents a valid model to study in vivo the thyroid hormone (zeige PTH Proteine) (TH) action, and the molecular mechanisms underlying the two syndromes of TH resistance, RTHa and RTHb.
zebrafish uses both alternative splicing and differential expression of TRalpha genes to diversify the cellular response to thyroid hormones.
there is considerable evidence that TRalpha plays an important role in fat deposition in porcine adipose tissue.
Furthermore, molecular and transgenic studies have shown that unliganded TRalpha accomplishes these via the recruitment of histone deacetylase (HDAC (zeige HDAC1 Proteine))-containing corepressor complexes to repress the expression of TH-inducible genes
Type 2 iodothyronine deiodinase (zeige DIO2 Proteine) activity is required for the death of thyroid hormone receptor (TRalpha)-transfected tail muscle cells induced by a low level of thyroid hormone (zeige PTH Proteine).
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 (zeige TBL1XR1 Proteine) complexes by unliganded thyroid hormone (zeige PTH Proteine) receptors in transcriptional repression during vertebrate development.
Data show that thyroid hormone (zeige PTH Proteine) receptors directly mediate the developmental effects of thyroid hormone (zeige PTH Proteine) in individual organs by regulating target gene expression in these organs.
investigated the role of steroid receptor coactivator (zeige SRA1 Proteine) 3 (SRC3 (zeige NCOA3 Proteine)) in gene activation by thyroid hormone receptor (TR) in vivo during development
Binding of liganded thyroid hormnone receptor to the target promoter is reduced when arginine methyltransferase 1 (zeige DNMT1 Proteine) was overexpressed, accompanied by a slight reduction in histone methylation.
PRMT1 functions transiently as a coactivator in thyroid hormone (zeige PTH Proteine) (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.
T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, V-erbA-related protein 1
, nuclear receptor Rev-ErbA-alpha
, nuclear receptor subfamily 1 group D member 1
, Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1)
, avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1
, c-erb-A thyroid hormone receptor
, nuclear receptor subfamily 1 group A member 1
, TR alpha 1
, TR alpha 2
, nuclear receptor subfamily 1 group A member 1-A
, thyroid hormone receptor alpha 1
, thyroid hormone receptor alpha-1
, thyroid hormone receptor alpha-A
, TR beta
, nuclear receptor subfamily 1 group A member 2
, ERBA-related 7
, V-erbA-related protein 7
, thyroid hormone receptor alpha
, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
, thyroid normone nuclear receptor alpha variant 1
, triiodothyronine receptor
, thyroid hormone receptor alpha2
, thyroid hormone receptor alpha 2
, c-erb-A protein
, thyroid hormone receptor alpha1
, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog)
, thyroid hormone receptor beta2
, thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)