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The expression RORalpha is significantly elevated under hypoxic conditions in keratinocytes in an HIF-1alpha (zeige HIF1A ELISA Kits) dependent manner.
Retinoid-related orphan receptor alpha-regulated development of the mouse cerebellum has a distinct critical period for (1) lengthening Purkinje cell (PC) primary dendrite stems and the eventual increase in the thickness of the molecular layer and (2) the establishment of mGluR (zeige GRM8 ELISA Kits) signaling and associated removal of surplus climbing fibers from PCs.
findings strongly suggest that CLDND1 is a direct RORalpha target
TRIB3 (zeige TRIB3 ELISA Kits) promotes acute promyelocytic leukemia (zeige PML ELISA Kits) progression through stabilization of the oncoprotein PML (zeige PML ELISA Kits)-RARalpha (zeige RARA ELISA Kits) and inhibition of p53 (zeige TP53 ELISA Kits)-mediated senescence.
Retinoid-related orphan receptor alpha (RORalpha) reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMP-activated protein kinase (AMPK (zeige PRKAA2 ELISA Kits)), therefore, both RORalpha and AMPK (zeige PRKAA1 ELISA Kits) are potential targets for the intervention and therapy in gastric carcinoma.
the RAR-related orphan receptor-a gene (RORA) and the Peroxisome Proliferator-Activated Receptor Gamma (zeige PPARG ELISA Kits), Coactivator 1 Alpha gene (PPARGC1A (zeige PPARGC1A ELISA Kits) or PGC-1alpha (zeige PPARGC1A ELISA Kits)) were significantly associated with the Li response. Our results suggest genetic associations between Li response and these two close biological partners: PPARGC1A (zeige PPARGC1A ELISA Kits) and RORA involved in circadian rhythms and bioenergetics processes in Li response
The present study is to determine if any relation exists between RORA rs11639084 and rs4774388 gene polymorphisms on the individual susceptibility of multiple sclerosis.
Association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China.
The RORA intronic SNP rs11632098 was associated with greater odds of reporting depressive symptoms in older adults.
A common SNP in the RORA gene (rs2899663) was associated with a 21% reduced odds of placental abruption.
study reports cloning and expression pattern of zebrafish ROR alpha orthologues rora1 and rora2; both rora1 and rora2 are spatially expressed in the retina and tectum; expression of rora2 was further observed in the cerebellum
that retinoic acid receptor-related orphan receptor alpha is a novel transcriptional regulator of SEMA3E (zeige SEMA3E ELISA Kits)-mediated neurovascular coupling in pathological retinal angiogenesis
The deficiency of LXRalpha (zeige NR1H3 ELISA Kits) decreased glucose uptake after MI, resulting in a metabolic shift that suppressed glucose metabolism, which was in association with adverse cardiac remodeling.
Data suggest that inflammatory response in macrophages, white adipocytes, and white adipose tissue in obese mice, includes up-regulation of expression of Rora; in adipose tissue, overexpression of Rora or treatment with Rora agonist enhances expression of cytokines, promotes macrophage infiltration, up-regulates expression of genes involved in ER stress response, and enhances signaling seen in unfolded protein response.
these findings reveal that RORalpha regulates macrophage M2 polarization via activation of AMPKalpha (zeige GRK4 ELISA Kits)
RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3 (zeige SOCS3 ELISA Kits)-dependent inflammation
This study showed that spontaneous Rora mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
the inhibition of NF-kappaB (zeige NFKB1 ELISA Kits) by melatonin, but not that of NLRP3 (zeige NLRP3 ELISA Kits), was blunted in RORalpha (sg/sg) mice, indicating that functional RORalpha transcription factor is necessary for the initiation of the innate immune response against inflammation.
Rora induces the mRNA level of antioxidant enzymes, superoxide dismutase 2 (zeige SOD2 ELISA Kits) and glutathione peroxidase 1 (zeige GPX1 ELISA Kits), through the Rora response elements located in the upstream promoters of Sod2 (zeige SOD2 ELISA Kits) and Gpx1 (zeige GPX1 ELISA Kits).
The nuclear receptors retinoic acid receptor (zeige RARA ELISA Kits)-related orphan receptors-alpha and gammat (RORalpha and RORgammat) play critical roles in the development of TH17 cells.
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.
nuclear receptor ROR-alpha
, RAR-related orphan receptor A
, RAR-related orphan receptor alpha
, nuclear receptor RZR-alpha
, nuclear receptor subfamily 1 group F member 1
, retinoic acid receptor-related orphan receptor alpha
, retinoid-related orphan receptor alpha
, thyroid hormone nuclear receptor alpha variant 4
, transcription factor RZR-alpha
, retinoid-related orphan receptor alpha 2
, retinoid-related orphan receptor-alpha