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We investigate the impact of central histology (n = 772), immunohistochemistry for intrinsic subtyping and IHC4, and dichotomous (GG) or continuous (GGI) genomic grade (n = 472) on patient outcome and benefit from taxane chemotherapy, focusing on HR+/HER2 (zeige ERBB2 Proteine)(HR: ER and/or PR)- patients (n = 459)
progesterone receptor expression status correlates with final pregnancy outcome
RA induced loss of PR binding only at the proximal site. Interestingly, RARalpha (zeige RARA Proteine) was recruited to the -1.1 kb PRE and the -130 bp PRE/RARE regions with P4, but not RA alone or RA plus P4
C/EBPbeta (zeige CEBPB Proteine) negatively regulates PR-B expression in glioblastoma cells.
Evaluation of progesterone expression in axillary lymph node metastasis of ER-positive, HER2 (zeige ERBB2 Proteine)-negative breast cancer may enable prediction of patients who are less likely to benefit from adjuvant tamoxifen.
findings suggest that GATAD2B (zeige GATAD2B Proteine) serves as an important mediator of progesterone-progesterone receptor suppression of proinflammatory and contractile genes during pregnancy; decreased GATAD2B (zeige GATAD2B Proteine) expression near term may contribute to the decline in progesterone receptor function, leading to labor
We sought to determine the relation between 17-alpha hydroxyprogesterone caproate plasma concentrations, progesterone receptor single nucleotide polymorphisms and single nucleotide polymorphisms in CYP3A4 (zeige CYP3A4 Proteine) and CYP3A5 (zeige CYP3A5 Proteine) and spontaneous preterm birth.
the estrogen- (ER), progesterone- (PgR) and HER2/neu (zeige ERBB2 Proteine) receptor status of the primary tumor with brain metastases in a series of 24 consecutive breast cancer patients, is reported.
we found that combinatorial MK-2206+progesterone treatments decreased angiogenesis and proliferation in the Pten(d/d) conditional mouse model of endometrial cancer. Taken together, these findings suggest that a combinatorial therapeutic approach utilizing Akt (zeige AKT1 Proteine) inhibitors with progestins may improve the efficacy of progestin therapy for the treatment of endometrial cancer.
The interplay between intracellular progesterone receptor and PRKCA (zeige PKCa Proteine)-PRKCD (zeige PKCd Proteine) plays a key role in migration and invasion of human glioblastoma cells.
Glandular epithelial androgen receptor (AR (zeige AR Proteine)) inactivation (with persistent stromal AR action) enhanced PTEN deletion-induced uterine pathology possibly by downregulating progesterone receptor expression in the uterus.
Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes.
loss of PGR impairs kisspeptin secretory machinery and therefore that PGR plays a critical role in regulating kisspeptin secretion.
PR isoforms are differentially regulated by estradiol and that the induction of PR-B expression is associated to specific transcription factors interactions and epigenetic changes in its promoter in embryonic hypothalamic cells.
The results show that mPges-1 (zeige PTGES Proteine) may be a direct downstream target gene of the progesterone receptor.
Progesterone receptor antagonism inhibits progestogen-related carcinogenesis and suppresses tumor cell proliferation.
generated a model to study the consequence of increased Notch (zeige NOTCH1 Proteine) signaling in female reproduction and provide the first evidence, to our knowledge, that Notch (zeige NOTCH1 Proteine) signaling can regulate epigenetic modification of the progesterone receptor
Calvarial cells had more potential to differentiate into osteoblasts and displayed more osteogeic markers after the PR expression was ablated from the Mx1+ cells. This indicates that PRs may play a role in the later stages of osteoblast differentiation.
progesterone receptor is a key contributor to the hypoxic ventilatory response in newborn mice
Progesterone receptor rapid and nonclassical transcriptional effects govern breast cancer growth.
Data suggest that the classical xPR-1, located at the plasma membrane, mediates reinitiation of the meiotic cell cycle in the X. laevis oocyte through a non-genomic mechanism.
Xenopus laevis progesterone receptor is capable of associating with the plasma membrane and this association is through its ligang-binding domain.
The expression of progesterone receptor in the uterotubular junction after deep intrauterine insemination with a reduced number of sperm was lower than after conventional artificial insemination and might influence sperm transportation and fertilization.
the digitonin-soluble progesterone binding protein (zeige PGRMC1 Proteine) has a binding site that differs from that of membrane PR; it is concluded that more than one progesterone receptor is present in porcine spermatozoa.
The expression of mRNAs for ERalpha (zeige ESR1 Proteine), ERbeta (zeige ESR2 Proteine) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Pgr is widely distributed in all regions of the zebrafish brain.
The localization of Pgr suggests that it mediates progestin regulation of reproductive signaling in the brain, early germ cell proliferation in testis, and ovarian follicular functions, but not final oocyte or sperm maturation.
11 beta-hydroxysteroid dehydrogenase activity stimulated by DHP (zeige DPYS Proteine) via Pgr
In vitro and in vivo effects of PGR knockdown in Luteinized granulosa cells also support the hypothesis that Progesterone enhances its own synthesis in the primate corpus luteum by promoting luteinization.
Data suggest that there are no changes in expression or localization patterns for PGR and PGRMC1 (zeige PGRMC1 Proteine) (progesterone receptor membrane component 2 (zeige PGRMC2 Proteine)) in endometrium in artificially cycled disease-free animals compared with an endometriosis model.
expression differences among PGR genotypes in oviduct and uterus and when differences appear during gestation
During early pregnancy mares had the same pattern of progesterone receptor in the endometrium as that reported for other mammals; namely, a loss of progesterone receptor from the endometrial epithelia but continued localization in stromal cells.
These results indicate that ptger4b expression is regulated by a genomic mechanism involving Pgr.
Progesterone upregulation of Gs proteins increases VIP (zeige Vip Proteine)-induced inhibition of intestinal smooth muscle cell contraction mediated by progesterone receptor A.(progesterone receptor A)
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
nuclear receptor subfamily 3 group C member 3
, p4 receptor
, Nuclear receptor subfamily 3 group C member 3
, progesterone receptor
, nuclear progesterone receptor Pgr