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There was no association between progesterone receptor expression and lymph node metastases in the epithelial ovarian cancer.An association between progesterone receptor expression and peritoneal metastases in endometrioid or high grade serous carcinoma.
Metaplastic breast cancer (MpBC) group had significantly more cases with no hormone receptors (ER, PR) and HER2 overexpression/gene amplification compared with the other invasive breast cancer types group (ER-, 69% versus 23%, p < 0.001; PR-, 69% versus 28%, p < 0.001; HER2 0/1+, 93% versus 82%, p = 0.019). Most MpBCs (62%) were triple-negative.
this study aimed to investigate the effects of membrane progesterone receptor-alpha subtype activation on proliferation, migration, and invasion of human glioblastoma cells.
Low progesterone receptor alpha and beta expression is associated with endometrial cancer.
Relative to ER, PR and HER2 from medical records, central IHC staining and the addition of Ki67 or combined tumor grade improved accuracy for classifying PAM50-based luminal subtypes.
The reciprocal expression of PGR and FOXO1 was conserved in endometrial samples during the proliferative and secretory phase. Expression of FOXO1 and the loss of PGR during the window of receptivity are interrelated and critical for embryo implantation.
Higher RDI of chemotherapy is associated with better survival for ER+/PR+, HER2- patients and triple-negative breast cancer(TNBC) patients. To optimize survival benefits, RDI should be maintained >/= 85% in ER+/PR+, HER2- patients, and >/= 75% in TNBC patients.
We have confirmed a positive association of specific progesterone receptor gene (PGR) variants (rs590688, rs10895068, and rs1942836) and PGR haplotypes (ATGCCGTC and ATTCGGTC) with an increased risk of recurrent pregnancy loss, thereby supporting a role PGR as an recurrent pregnancy loss candidate locus.
These data predict that under conditions where O-GlcNAc levels are high (breast cancer) progesterone receptor (PR) through an interaction with the modifying enzyme OGT, will exhibit increased O-GlcNAcylation and potentiated transcriptional activity. Therapeutic strategies aimed at altering cellular O-GlcNAc levels may have profound effects on PR transcriptional activity in breast cancer
estimates for gene-expression (GE) were added for ER (gene ESR1), for PGR (gene PGR) and for HER2 (gene ERBB2). Combined results were obtained in each patient via a scoring system based on all three receptors
Significant association between the presence of PROGINS progesterone receptor mutation and Hepatitis E virus seroprevalence in individuals infected with HIV
the estrogen receptor (ER) and progesterone receptor (PR), as well as human epidermal growth factor receptor 2 (Her2neu) expressions in breast tumor cells, were evaluated.
The combined genotype PGR +331TT/CYP17A1 -34AA/CYP19A11531AA is positively associated with endometriosis
We found that the Alu insertion was associated with breast cancer incidence in Indians and Indo-European mixed racial groups, but the association disappeared for patients of Caucasian or Latino decent. Our meta-analysis showed that the Alu-insertion progesterone receptor gene polymorphism was not associated with breast cancer. [Meta-analysis]
findings showed no association between PROGINS and leiomyoma in the overall analysis nor in either of the subgroups, Asian or non-Asian, in all genetic models;. conclusion: The PROGINS polymorphisms cannot be considered a risk factor for developing uterine leiomyoma - Systematic Review and Meta-Analysis
in primary breast tumors, PR-A expression was correlated negatively with miR-92a-3p expression and positively with miR-26b-5p expression. Therefore, hormonal cross-talk of PR-A with ER is probably a fundamental mechanism that enables metastasis of luminal breast cancer.
heterogeneous distribution in deep infiltrating endometriosis
This study aimed to determine the presence and localization of oestrogen receptors (ERs), progesterone receptors (PRs), and androgen receptors (ARs) in both healthy and varicose vein wall cells and their relationship with gender.
These findings suggest that in myometrial cells the repressive activity of PR-A on PR-B increases with advancing gestation and is induced by pro-inflammatory cytokines.
polymorphisms do not predict in vitro fertilization outcome
Endogenous C/EBPbeta and c-Jun stimulated a PR promoter-reporter and these two factors showed promoter occupancy on the endogenous PR gene.
Demonstrate that the transcription factor Forkhead Box O1 (FOXO1) is a critical regulator of endometrial receptivity in vivo. Uterine ablation of Foxo1 using the progesterone receptor Cre (PgrCre) model resulted in infertility due to altered epithelial cell polarity and apoptosis, preventing the embryo from penetrating the luminal epithelium.
Downregulation of the PGRA isoform at the window of receptivity is necessary to produce a receptive environment for the attaching embryo.
PR inactivation in early osteoprogenitor cells but not in mature osteoblasts influenced trabecular bone accrual in a sex-dependent manner. PR deletion in osteoblast lineage cells did not affect cortical bone mass.
Our results identified PIK3IP1 as a novel target of ARID1A and PGR in the murine uterus.
Glandular epithelial androgen receptor (AR) inactivation (with persistent stromal AR action) enhanced PTEN deletion-induced uterine pathology possibly by downregulating progesterone receptor expression in the uterus.
Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes.
loss of PGR impairs kisspeptin secretory machinery and therefore that PGR plays a critical role in regulating kisspeptin secretion.
PR isoforms are differentially regulated by estradiol and that the induction of PR-B expression is associated to specific transcription factors interactions and epigenetic changes in its promoter in embryonic hypothalamic cells.
The results show that mPges-1 may be a direct downstream target gene of the progesterone receptor.
Progesterone receptor antagonism inhibits progestogen-related carcinogenesis and suppresses tumor cell proliferation.
generated a model to study the consequence of increased Notch signaling in female reproduction and provide the first evidence, to our knowledge, that Notch signaling can regulate epigenetic modification of the progesterone receptor
Calvarial cells had more potential to differentiate into osteoblasts and displayed more osteogeic markers after the PR expression was ablated from the Mx1+ cells. This indicates that PRs may play a role in the later stages of osteoblast differentiation.
The effects of dexamethasone on uterine epithelial proliferation occur partially through non-progesterone mechanisms, but also through progesterone receptors.
progesterone receptor is a key contributor to the hypoxic ventilatory response in newborn mice
Progesterone/estrogen receptors are expressed in different epithelial populations, and target non-overlapping pathways in the normal human breast. In breast cancer, PR becomes highly correlated with ER.
Progesterone receptor rapid and nonclassical transcriptional effects govern breast cancer growth.
PgR expression may play an important role in the maturation of cortical connectivity and sensorimotor
RANKL is a direct progesterone receptor (PR) target gene and Stat5a has a novel role as a cofactor in PR-mediated transcriptional signaling in the mammary gland.
Study shows that PR is able to selectively target the endometrial vasculature in a coordinated and sustained permeability response.
results suggest that the dual functions of progesterone, transcription-dependent follicle rupture and transcription-independent oocyte maturation, are mediated by the two forms of PR proteins differentially expressed in the follicle cells and the oocytes
Data suggest that the classical xPR-1, located at the plasma membrane, mediates reinitiation of the meiotic cell cycle in the X. laevis oocyte through a non-genomic mechanism.
Xenopus laevis progesterone receptor is capable of associating with the plasma membrane and this association is through its ligang-binding domain.
The expression of progesterone receptor in the uterotubular junction after deep intrauterine insemination with a reduced number of sperm was lower than after conventional artificial insemination and might influence sperm transportation and fertilization.
The differential distribution and variations in the scores for PGRA and PGRB in various pig ovarian cell types during the cycle may reflect diverse functions for PGRA and PGRB as well as suggest a cell-specific influence of progesterone.
the digitonin-soluble progesterone binding protein has a binding site that differs from that of membrane PR; it is concluded that more than one progesterone receptor is present in porcine spermatozoa.
confirmed presence of specific PR in the oviduct and demonstrated existence of a direct relation between the variations in PR concentrations and the differences in PR binding activity in oviductal ampulla and isthmus during follicular and luteal phases
The expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Pgr is widely distributed in all regions of the zebrafish brain.
The localization of Pgr suggests that it mediates progestin regulation of reproductive signaling in the brain, early germ cell proliferation in testis, and ovarian follicular functions, but not final oocyte or sperm maturation.
11 beta-hydroxysteroid dehydrogenase activity stimulated by DHP via Pgr
In vitro and in vivo effects of PGR knockdown in Luteinized granulosa cells also support the hypothesis that Progesterone enhances its own synthesis in the primate corpus luteum by promoting luteinization.
Data suggest that there are no changes in expression or localization patterns for PGR and PGRMC1 (progesterone receptor membrane component 2) in endometrium in artificially cycled disease-free animals compared with an endometriosis model.
PR activation around the time of mating and a post-mating decline in ovarian estradiol secretion and/or estradiol responsiveness act in parallel to terminate estrus in this species.
Differential time course and tissue specific immunoreactivity for PR in the uterus of the rabbit in two progestational conditions.
expression differences among PGR genotypes in oviduct and uterus and when differences appear during gestation
The wide distribution of PR mRNA in the rabbit brain suggests that progesterone through PR activation is involved in several functions apart from reproductive behavior in rabbits, and that PR expression is up-regulated by estradiol in the rabbit brain.
During early pregnancy mares had the same pattern of progesterone receptor in the endometrium as that reported for other mammals; namely, a loss of progesterone receptor from the endometrial epithelia but continued localization in stromal cells.
microplacentomes gives evidence for a role of placental steroids as regulators of placental function
A differential timing of expression of Pgr and Cebpb in the preovulatory follicles appears to explain the considerably long time-lag from the pgr gene activation to mmp15 gene expression.
These results indicate that ptger4b expression is regulated by a genomic mechanism involving Pgr.
Progesterone upregulation of Gs proteins increases VIP-induced inhibition of intestinal smooth muscle cell contraction mediated by progesterone receptor A.(progesterone receptor A)
The decreasing expression of both progesterone receptors A and B is a physiological mechanism of functional progesterone withdrawal in the guinea pig during late pregnancy and in labor.
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
nuclear receptor subfamily 3 group C member 3
, p4 receptor
, Nuclear receptor subfamily 3 group C member 3
, progesterone receptor
, nuclear progesterone receptor Pgr