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PARP1 (zeige PARP1 Proteine) inhibitor also suppressed the aldosterone secretion in response to the angiotensin II. Together, these results suggest PARP1 (zeige PARP1 Proteine) is a prime coregulator for Nurr1.
Data expand the understanding of the mechanism by which the NR4A2 nuclear receptor can facilitate DNA DSB repair.
An association was identified in a Mexican population between genotype and mRNA expression levels of NR4A2 in patients with Parkinson's disease.
miR (zeige MLXIP Proteine)-34 was identified as a direct negative regulator of NR4A2. A novel regulatory network linking p53 (zeige TP53 Proteine), miR (zeige MLXIP Proteine)-34, and NR4A2 was revealed, in which p53 (zeige TP53 Proteine) can overcome its inhibition by endogenous NR4A2 through upregulating miR (zeige MLXIP Proteine)-34.
Nurr1 was induced during intestinal regeneration after I/R injury. Nurr1 promoted proliferation of intestinal epithelial cells after H/R injury. Nurr1 inhibited p21 (zeige CDKN1A Proteine) expression in a p53 (zeige TP53 Proteine)-independent manner. Nurr1 inhibited p21 (zeige CDKN1A Proteine) gene transcription by binding to p21 (zeige CDKN1A Proteine) promoter directly.
Our findings of a de novo deletion of NR4A2 in an individual with mild intellectual disability and prominent speech and language impairment provides further evidence for NR4A2 haploinsufficiency being causative for neurodevelopmental and particularly language phenotypes
Findings support that Notch1 (zeige NOTCH1 Proteine)/NR4A2 co-regulate HCC (zeige FAM126A Proteine) cell functions by playing oncogenic roles and regulating the associated downstream signaling pathways.
NR4A sub-family of nuclear orphan receptors (Nor-1 (zeige NR4A3 Proteine), Nurr-1 and Nur-77 (zeige NR4A1 Proteine)) may have a role in trophoblastic cell differentiation.
this study shows over-expression of NR4A2 mRNA in peripheral CD4 (zeige CD4 Proteine)+ T cells of Sjogren's syndrome patients
NR4A2 and NR4A3 (zeige NR4A3 Proteine) are components of a downstream transcriptional response to PKA activation in the neutrophil, and that they positively regulate neutrophil survival and homeostasis.
The study comprehensively evaluated the association of NR4A2 variation with PD, and the results failed to demonstrate that the NR4A2 polymorphisms significantly associated with PD except for rs35479735, suggesting that more studies are needed to elucidate if NR4A2 is a risk of PD.
The Nurr1 expression may play a significant role in regulating inflammation in the brain.
Knockdown of DJ-1 (zeige PARK7 Proteine) attenuates Nurr1 activity.
Overexpression of Nurr1 and Pitx3 (zeige PITX3 Proteine) in iPSCs could efficiently program induced pluripotent stem cells into functional dopaminergic-like neurons. This finding may have an impact on future stem cell therapy of Parkinson's disease.
Overexpression and knockdown of Nr4a2 demonstrated that Nr4a2 orchestrates the expression of immunoregulatory genes, hence inducing a tolerogenic phenotype in bone marrow derived dendritic cells (DC) in mice. The findings suggest a previously unidentified role for Nr4a2 as a regulator of dendritic cell tolerogenicity and demonstrate its potential as therapeutic target in DC-associated pathophysiologies.
Nurr1 defect induces early experimental autoimmune encephalomyelitis (EAE) onset and increases inflammatory infiltrates in spinal cord suggesting a Nurr1 role in the early phase of EAE
Nr4a2 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions.
Results indicate that Nurr1 overexpression in olfactory bulb stem cells induces the formation of two populations of mature dopaminergic neurons with features of the ventral mesencephalon or of the olfactory bulb
Nurr1 +/- genotype predisposes mice to T. gondii-induced alterations in behaviors that involve dopamine neurotransmission
The authors show herein that Nurr1 and Foxa2 (zeige FOXA2 Proteine) interact to protect midbrain dopaminergic neurons against various toxic insults, but their expression is lost during aging and degenerative processes.
data indicate a conserved evolutionary role of Nr4a2 proteins in specification of the neurotransmitter phenotype
Results shed new light on NR4A2 function in the dopamine differentiation pathway, and stress the effect of dopamine dysregulation on the control of locomotor activity.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
nuclear receptor subfamily 4, group A, member 2
, nuclear receptor
, nuclear receptor related 1
, nuclear receptor subfamily 4 group A member 2
, Nuclear receptor subfamily 4 group A member 2
, NGFI-B/nur77 beta-type transcription factor homolog
, T-cell nuclear receptor NOT
, immediate-early response protein NOT
, intermediate-early receptor protein
, nur related protein-1, human homolog of
, orphan nuclear receptor NR4A2
, orphan nuclear receptor NURR1
, transcriptionally inducible nuclear receptor related 1
, transcriptionally-inducible nuclear receptor
, NUR-related factor 1
, nuclear orphan receptor HZF-3
, nuclear receptor subfamily 4 group A member 2 variant TINUR
, nuclear receptor subfamily 4 group A member 2 variant NURR1a
, nuclear receptor subfamily 4 group A member 2 variant NURR1b
, nuclear receptor subfamily 4 group A member 2 variant NURR1c
, nuclear receptor subfamily 4 group A member 2 variant NURR2c
, nur related protein 1
, regenerating liver nuclear receptor 1
, nerve growth factor 1b
, neural orphan nuclear receptor