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TGFalpha modulates epithelial-mesenchymal transition (EMT) markers and NFkappaB signaling pathway in colon cancer cells.
The frequency of A allele in all the case groups and control groups was 50% and 2%, respectively, in the cleft lip cases was 50%, and in the cleft lip and palate cases was 50%. There was a statistically significant difference between genotype frequency of TGFalpha/HinfI polymorphisms in nsCL cases, nsCL+P cases, and nsCL +/- P cases compared with controls (p = 0.029, p = 0.024, and p = 0.0365, respectively).
The abnormally elevated expression of EGF and TGF-alpha are closely associated with the occurrence and development of chronic pancreatitis and pancreatic cancer
MiR-199a-5p may mediate cleft lip with or without cleft palate by regulating key target gene TGFA.
this study demonstrated that TP73-AS1 regulated Colorectal cancer (CRC)progression by acting as a competitive endogenous RNA to sponge miR-194 to modulate the expression of TGFa
There was evidence suggestive of gene-gene joint-effects between MTHFR-TGFA for nsCP but not for nsCL+/-P.
TGFA TaqI polymorphism was not associated with the risk of nonsyndromic cleft lip and/or palate in Iranian children.
We identi fi ed a signi fi cant association between the SNP rs2862851 and disease status of knee Osteoarthritis. Allelic analyses showed that the T allele of this SNP signi fi cantly elevated the risks of Osteoarthritis. Haplotype-based analyses have also identi fi ed a strong association signal between one haplotype block, including rs2862851, and the disease status of knee Osteoarthritis.
Results suggest a long non-coding RNA MALAT1/MIR376A/transforming growth factor alpha (TGFA) axis mediates osteosarcoma (OS) cell proliferation and tumor progression.
The association of the TGFA gene with NS-CL+/-P in Korean populations was not clearly found. However, the etiologic effect of the TGFA gene on NS-CL+/-P patients should be investigated in terms of maternal genotype influence.
These results support that two SNPs are associated with nonsyndromic CL/P but not for CP in northern Chinese populations.
There were no significant differences in GE area of infertile and fertile women. C-C motif chemokine 11 (P=0.048), TGFalpha (P=0.049), IFNgamma (P=0.033) and interleukin-1 alpha (P=0.047) were significantly elevated in uterine lavage from infertile women <35years compared to fertile but not in women 35years
results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFalpha-TGFalpha-EGFR.
In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 and TREH) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human Osteoarthritis, which may serve as a new target for future therapies.
Our study showed that TGFA/TGFB3/MSX1 gene polymorphisms were associated with congenital NSHI. The distribution of genotype frequencies and allele frequencies of TGFA rs3771494, TGFB3 rs3917201 and rs2268626, and MSX1 rs3821949 and rs62636562 were significantly different between the case and the control groups
TGFA gene expression is regulated by MiR-374a in lung adenocarcinoma.TGFA plays role in lung adenocarcinoma cell proliferation and invasion.
Overall, our findings indicated that intratumoral administration of TGFalphaL3-SEB effectively inhibited the growth of breast tumors through induction of necrosis and suppressing proliferation and angiogenesis without systemic toxicity.
TGFA expression decreased after 10 and 30min of treatment even when transcription was not inhibited. We found that activation of PI3K was necessary for triiodothyronine to modulate HIF1A and TGFA expression
This is the first demonstration that miR-490-3P might act as a suppressor in endometrial cancer tumorigenesis and progression by targeting TGFalpha.
miR-505 acts as tumor suppressor in endometrial cancer by regulating TGF-alpha.
upregulation of TGFalpha or FGF2 expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
Tgfa null mice are equally susceptible to spontaneous osteoarthritis development during aging.
Here the authors show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFalpha, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles.
TGF-alpha contributes to the progression of diabetic kidney disease.
Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFalpha in eyelid stroma.
c-Myc and transforming growth factor alpha enhance the development of hepatic lesions due to mutant beta-catenin in transgenic mice.
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
findings suggest that elevated PHD4 levels disturb the angiogenic balance in osteosarcoma via induction of the TGF-alpha pathway and inhibit tumor growth by reducing the expression of HIF-2alpha
Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
TGFalpha appears to be an important growth factor regulating the conversion of cartilage to bone during the process of endochondral ossification.
These results imply that TGFalpha stimulates proliferation of endometrial stromal cells through multiple mechanisms, including its regulation of Igfbp3 and Mmp3 transcription.
ADAM-17 and TGF-alpha are strongly and locally upregulated following adult mice cortical damage.
Different mechanisms regulate neurogenesis in neonatal and adult olfactory epithelium; fibroblast growth factor (FGF)2 and TGFalpha may have different roles throughout development.
beta-catenin controlled both cell-autonomous and non-cell-autonomous hepatocyte proliferation, through direct transcriptional and complex control of cyclin D1 gene expression and of the expression of a new target gene, Tgfalpha.
variable TGF-alpha expression may explain, in part, the genetic susceptibility to chronic kidney disease (CKD) progression.
our results suggest that TGFalpha overexpression in mouse urogenital organs alone may not be responsible for tumor formation and epithelial hyperplasia, but is involved in bladder outlet obstruction
This may be the first report of the expression of carcinogenesis-related molecules such as EGFR, K-ras, Cox2 and TGFalpha during chronic pancreatitis.
EGFR-dependent increases in receptor ligands TGFa and PTGS2 likely drive diet-related tumor promotion
TGFalpha has a role in the development of preneoplastic melanocytic lesions in the eye but not the skin
TGF-alpha produced primarily in the somatotrophs mediates the stimulatory effects of estrogen on the DNA replication of pituitary cells in a paracrine or autocrine manner
TGF-alpha might affect astrocytic hypertrophy without affecting microgliosis not only in the normal condition, but also in the pathological condition.
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, protransforming growth factor alpha
, transforming growth factor alpha
, transforming growth factor, alpha
, transforming growth factor-alpha
, waved 1
, TGF alpha