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Results suggest a long non-coding RNA MALAT1/MIR376A/transforming growth factor alpha (TGFA) axis mediates osteosarcoma (OS) cell proliferation and tumor progression.
The association of the TGFA gene with NS-CL+/-P in Korean populations was not clearly found. However, the etiologic effect of the TGFA gene on NS-CL+/-P patients should be investigated in terms of maternal genotype influence.
There were no significant differences in GE area of infertile and fertile women. C-C motif chemokine 11 (P=0.048), TGFalpha (P=0.049), IFNgamma (P=0.033) and interleukin-1 alpha (zeige IL1A Proteine) (P=0.047) were significantly elevated in uterine lavage from infertile women <35years compared to fertile but not in women 35years
results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFalpha (zeige TNF Proteine)-TGFalpha-EGFR (zeige EGFR Proteine).
In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 (zeige FGFR3 Proteine) and TREH (zeige TREH Proteine)) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human Osteoarthritis, which may serve as a new target for future therapies.
Our study showed that TGFA/TGFB3 (zeige TGFB3 Proteine)/MSX1 (zeige MSX1 Proteine) gene polymorphisms were associated with congenital NSHI. The distribution of genotype frequencies and allele frequencies of TGFA rs3771494, TGFB3 (zeige TGFB3 Proteine) rs3917201 and rs2268626, and MSX1 (zeige MSX1 Proteine) rs3821949 and rs62636562 were significantly different between the case and the control groups
TGFA gene expression is regulated by MiR (zeige MLXIP Proteine)-374a in lung adenocarcinoma.TGFA plays role in lung adenocarcinoma cell proliferation and invasion.
Overall, our findings indicated that intratumoral administration of TGFalphaL3-SEB effectively inhibited the growth of breast tumors through induction of necrosis and suppressing proliferation and angiogenesis without systemic toxicity.
TGFA expression decreased after 10 and 30min of treatment even when transcription was not inhibited. We found that activation of PI3K (zeige PIK3CA Proteine) was necessary for triiodothyronine to modulate HIF1A (zeige HIF1A Proteine) and TGFA expression
This is the first demonstration that miR (zeige MLXIP Proteine)-490-3P might act as a suppressor in endometrial cancer tumorigenesis and progression by targeting TGFalpha.
upregulation of TGFalpha or FGF2 (zeige FGF2 Proteine) expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
Tgfa null mice are equally susceptible to spontaneous osteoarthritis development during aging.
Here the authors show that the mammalian rhomboid protease RHBDL4 (zeige RHBDL3 Proteine) (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR (zeige EGFR Proteine) ligand TGFalpha, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles.
TGF-alpha contributes to the progression of diabetic kidney disease.
c-Myc (zeige MYC Proteine) and transforming growth factor alpha enhance the development of hepatic lesions due to mutant beta-catenin (zeige CTNNB1 Proteine) in transgenic mice.
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
findings suggest that elevated PHD4 (zeige P4HTM Proteine) levels disturb the angiogenic balance in osteosarcoma via induction of the TGF-alpha pathway and inhibit tumor growth by reducing the expression of HIF-2alpha (zeige EPAS1 Proteine)
Interaction between IRF6 (zeige IRF6 Proteine) and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
These results imply that TGFalpha stimulates proliferation of endometrial stromal cells through multiple mechanisms, including its regulation of Igfbp3 (zeige IGFBP3 Proteine) and Mmp3 (zeige MMP3 Proteine) transcription.
ADAM-17 (zeige ADAM17 Proteine) and TGF-alpha are strongly and locally upregulated following adult mice cortical damage.
Different mechanisms regulate neurogenesis in neonatal and adult olfactory epithelium; fibroblast growth factor (FGF)2 (zeige FGF2 Proteine) and TGFalpha may have different roles throughout development.
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, protransforming growth factor alpha
, transforming growth factor alpha
, transforming growth factor, alpha
, transforming growth factor-alpha
, waved 1