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Human NFKBIA Protein expressed in Escherichia coli (E. coli) - ABIN2004994
Scherer, Brockman, Chen, Maniatis, Ballard: Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. in Proceedings of the National Academy of Sciences of the United States of America 1995
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Combined computational and biochemical studies indicated that the extent of NF-kappaB (zeige NFKB1 Proteine)-responsive expression of Nfkbia, which encodes IkappaBalpha, inversely correlated with cross-talk. The Nfkbia promoter showed enhanced responsiveness to NF-kappaB (zeige NFKB1 Proteine) activation in macrophages compared to that in fibroblasts
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB (zeige NFKB1 Proteine)(p65 (zeige NFkBP65 Proteine)), miR (zeige MLXIP Proteine)-196b-3p, Meis2 (zeige MEIS2 Proteine), and PPP3CC (zeige PPP3CC Proteine) is formed during the emergence of castration-resistant prostate cancer.
Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.
SM22alpha (zeige TAGLN Proteine) is a phosphorylation-regulated (zeige PHAX Proteine) suppressor of IKK (zeige CHUK Proteine)-IkappaBalpha-NF-kappaB (zeige NFKB1 Proteine) signaling cascades.
We found potential links between the alterations in expression of Tsc22d3 (zeige TSC22D3 Proteine), Nfkbia and Pdyn (zeige PDYN Proteine), and different aspects of susceptibility to stress.
Specific and constitutive deletion of the inhibitor of NF-kappaB (zeige NFKB1 Proteine) (IkappaBalpha) in eosinophils in vivo reduced apoptosis during helminth infection
GRK6 (zeige GRK6 Proteine) directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 (zeige GRK6 Proteine) suppresses TNF-alpha (zeige TNF Proteine)-induced NF-kappaappaB signaling.
Results demonstrate novel roles of TNFRII (zeige TNFRSF1B Proteine) in the regulation of Abeta (zeige APP Proteine) production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII (zeige TNFRSF1B Proteine) levels and elevating phosphorylated IkappaBalpha by SUMOylation.
Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IkappaBalpha.
Dengue virus protease interacts with both NF-kappaB inhibitor alpha (IkappaBalpha) and NF-kappaB (zeige NFKB1 Proteine) inhibitor beta (IkappaBbeta (zeige NFKBIB Proteine)), cleaving them in a mouse hemorrhage model.
the results of real-time PCR and western blotting revealed that Huaier extract decreased p65 and c-Met expression and increased IkappaBalpha expression, while paclitaxel increased p65 expression and reduced IkappaBalpha and c-Met expression.The molecular mechanisms may be involved in the inhibition of the NF-kappaB pathway and c-Met expression
association between polymorphisms and progression of chronic hepatitis B Virus infection among Chinese Han Population
miR (zeige MLXIP Proteine)-668 was upregulated in radioresistant human breast cancer cell lines MCF-7R and T-47DR, which targeted IkappaBalpha, activated the NF-kappaB (zeige NFKB1 Proteine) pathway and thus increased the radioresistance of breast cancer cells.
We showed that pristimerin suppressed tumor necrosis factor a (TNFalpha)-induced IkappaBa phosphorylation, translocation of p65, and expression of NFkappaB-dependent genes. Moreover, pristimerin decreased cell viability and clonogenic ability of Uveal melanoma (UM)cells. A synergistic effect was observed in the treatment of pristimerin combined with vinblastine, a frontline therapeutic agent, in UM.
Data collectively demonstrate the functional importance of IkappaBalpha-mediated stripping of NFkappaB from DNA in the kinetic control of NFkappaB signaling.
These findings indicate that genetic polymorphisms of NFKB1A rs696, pre-miR (zeige MLXIP Proteine)-146a rs2910164 and pre-miR (zeige MLXIP Proteine)-499 rs3746444 may represent novel markers of AT susceptibility.
XPO1 (zeige XPO1 Proteine) inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IkappaBalpha and overcomes acquired proteasome inhibitor resistance in human multiple myeloma.
Molecular docking analysis indicated that transcription factor NF-kappaB (zeige NFKB1 Proteine) was one of the potential molecular targets modulated by DTTF. Specifically, the drug blocked the TNFalpha (zeige TNF Proteine)-induced phosphorylation of upstream IkappaBalpha kinase in a time-dependent manner leading to the suppression of NF-kappaB (zeige NFKB1 Proteine) activation and nuclear translocation
FBXO32 (zeige FBXO32 Proteine) activates NF-kappaB (zeige NFKB1 Proteine) through IkappaBalpha degradation in inflammatory and genotoxic stress
The results showed that NFKB1 (zeige NFKB1 Proteine) and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.
An oligonucleotidebased method was applied to construct the vector for conditional targeting of porcine IkappaBalpha. This method was free from PCR amplification during the assembling of the different vector elements, avoiding introduction of unwanted mutations.
IkappaB-alpha protein was stabilized by COMMD1 (zeige COMMD1 Proteine), which attenuated NF-kappaB (zeige NFKB1 Proteine) signaling during Toll (zeige TLR4 Proteine)-like receptor ligand and tumor necrosis factor alpha (zeige TNF Proteine) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.
NFKBIA has a role as a marker of NF-kappaB (zeige NFKB1 Proteine)/p65 (zeige SYT1 Proteine) activation in the early embryo.
NF-kappaB (zeige NFKB1 Proteine) has a role in increasing PDGF-B (zeige PDGFB Proteine) transcription
AIP1 (zeige PDCD6IP Proteine) is a novel transducer in TNF (zeige TNF Proteine)-induced TRAF2 (zeige TRAF2 Proteine)-dependent activation of ASK1 (zeige MAP3K5 Proteine) that mediates a balance between JNK (zeige MAPK8 Proteine) versus NF-kappaB (zeige NFKB1 Proteine) signaling
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
NF-kappa-B inhibitor alpha
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light polyp gene enhancer in B-cell 1
, major histocompatibility complex enhancer-binding protein MAD3
, nuclear factor of kappa light chain gene enhancer in B-cells
, I kappa B-alpha
, NF-kappaB inhibitor alpha
, REL-associated protein pp40
, Rel-associated pp40
, IkappaB alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha