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Human NFKBIA Protein expressed in Escherichia coli (E. coli) - ABIN2004994
Scherer, Brockman, Chen, Maniatis, Ballard: Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. in Proceedings of the National Academy of Sciences of the United States of America 1995
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this study shows changes of NF-kB expression levels induced by cell-free DNA in different cell types
the results of real-time PCR and western blotting revealed that Huaier extract decreased p65 and c-Met expression and increased IkappaBalpha expression, while paclitaxel increased p65 expression and reduced IkappaBalpha and c-Met expression.The molecular mechanisms may be involved in the inhibition of the NF-kappaB pathway and c-Met expression
Colorectal cancer cases showed an increase in the frequency of NFkappaBIA-881G allele in Egyptian subjects.
association between polymorphisms and progression of chronic hepatitis B Virus infection among Chinese Han Population
miR-668 was upregulated in radioresistant human breast cancer cell lines MCF-7R and T-47DR, which targeted IkappaBalpha, activated the NF-kappaB pathway and thus increased the radioresistance of breast cancer cells.
We showed that pristimerin suppressed tumor necrosis factor a (TNFalpha)-induced IkappaBa phosphorylation, translocation of p65, and expression of NFkappaB-dependent genes. Moreover, pristimerin decreased cell viability and clonogenic ability of Uveal melanoma (UM)cells. A synergistic effect was observed in the treatment of pristimerin combined with vinblastine, a frontline therapeutic agent, in UM.
Data collectively demonstrate the functional importance of IkappaBalpha-mediated stripping of NFkappaB from DNA in the kinetic control of NFkappaB signaling.
These findings indicate that genetic polymorphisms of NFKB1A rs696, pre-miR-146a rs2910164 and pre-miR-499 rs3746444 may represent novel markers of AT susceptibility.
XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IkappaBalpha and overcomes acquired proteasome inhibitor resistance in human multiple myeloma.
Molecular docking analysis indicated that transcription factor NF-kappaB was one of the potential molecular targets modulated by DTTF. Specifically, the drug blocked the TNFalpha-induced phosphorylation of upstream IkappaBalpha kinase in a time-dependent manner leading to the suppression of NF-kappaB activation and nuclear translocation
FBXO32 activates NF-kappaB through IkappaBalpha degradation in inflammatory and genotoxic stress
We show that HOTAIR regulates activation of NF-kB by decreasing Ik-Ba (NF-kB inhibitor) and establish that by inducing prolonged NF-kB activation and expression of NF-kB target genes during DNA damage, HOTAIR has a critical role in cellular senescence and platinum sensitivity
The results showed that NFKB1 and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.
Double phosphorylation-induced structural changes in the signal-receiving domain of IkappaBalpha in complex with NF-kappaB have been described.
Here, the authors report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (RelA-p50) heterodimer induced by DNA or IkappaBalpha binding.
Sam68 is essential for DNA damage-induced NF-kappaB activation and colon tumorigenesis.
Specifically, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB components in the cytoplasm. Since HIV-1 utilizes NF-kappaB to promote proviral transcription, the BCA2-mediated inhibition of NF-kappaB significantly decreases the transcriptional activity of HIV-1.
This study found that NFKBIA mRNAs was significantly expressed in normal tissues compared with glioma specimens.
Findings indicate the prognostic value of NFKB inhibitor alpha (NFKBIA) in lower-grade gliomas (LGGs).
W346 effectively inhibited tumor necrosis factor (TNF-a)-induced NF-kappaB activation by suppressing IKK phosphorylation, inhibiting IkB-a degradation, and restraining the accumulation of NF-kappaB subunit p65 nuclear translocation. W346 also affected NF-kappaB-regulated downstream products involved in cycle arrest and apoptosis.
These results indicate that dihydroartemisinin represses RANKL-induced osteoclastogenesis of bone marrow macrophages through reduced NFATc1 expression and impaired phosphorylation of IkappaBalpha.
Combined computational and biochemical studies indicated that the extent of NF-kappaB-responsive expression of Nfkbia, which encodes IkappaBalpha, inversely correlated with cross-talk. The Nfkbia promoter showed enhanced responsiveness to NF-kappaB activation in macrophages compared to that in fibroblasts
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB(p65), miR-196b-3p, Meis2, and PPP3CC is formed during the emergence of castration-resistant prostate cancer.
Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.
SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.
We found potential links between the alterations in expression of Tsc22d3, Nfkbia and Pdyn, and different aspects of susceptibility to stress.
Specific and constitutive deletion of the inhibitor of NF-kappaB (IkappaBalpha) in eosinophils in vivo reduced apoptosis during helminth infection
GRK6 directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha-induced NF-kappaappaB signaling.
Results demonstrate novel roles of TNFRII in the regulation of Abeta production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII levels and elevating phosphorylated IkappaBalpha by SUMOylation.
Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IkappaBalpha.
Dengue virus protease interacts with both NF-kappaB inhibitor alpha (IkappaBalpha) and NF-kappaB inhibitor beta (IkappaBbeta), cleaving them in a mouse hemorrhage model.
The results indicate that following heat shock treatment, HuR translocates from the nucleus to the cytoplasm, forming stress granules and regulating the translation of IkBalpha mRNA without affecting the half-life.
Data show that inhibition of nuclear factor-kappaB (NF-kappaB) in IKBM protects the mice from monocrotaline (MCT)-induced pulmonary arterial hypertension and right ventricular hypertrophy.
Wedelolactone inhibited lipopolysaccharide -induced NF-kappaB p65 activation via the degradation and phosphorylation of IkappaB-alpha and subsequent translocation of the NF-kappaB p65 subunit to the nucleus.
Iron caused apoptosis mainly by the intrinsic pathway via the down-regulation of IkappaBalpha with a concomitant up-regulation of NF-kB as well as the phosphorylation of ERKs and p38 MAP kinases.
ZBTB20 specifically binds to +1 to +60 region of IkappaBalpha gene promoter after Toll-like receptor activation and can inhibit IkappaBalpha gene transcription, govern IkappaBalpha protein expression, and finally promote NF-kappaB activation.
Pancreas-specific deletion of IkappaBalpha results in nuclear translocation of RelA and reduces acute pancreatitis induction and trypsin activation in mice after administration of cerulein or L-arginine.
Data show that NEMO forms a complex with IKKbeta and IkappaBalpha.
The consequences of the disruption of Npr1 gene on proinflammatory responses of nuclear factor kappa B, inhibitory kappa B kinase, and inhibitory kappa B alpha (NF-kappaB, IKK, IkappaBalpha) in the kidneys of mutant mice, was determined.
Myeloid IkappaBalpha deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques.
An oligonucleotidebased method was applied to construct the vector for conditional targeting of porcine IkappaBalpha. This method was free from PCR amplification during the assembling of the different vector elements, avoiding introduction of unwanted mutations.
IkappaB-alpha protein was stabilized by COMMD1, which attenuated NF-kappaB signaling during Toll-like receptor ligand and tumor necrosis factor alpha treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.
NFKBIA has a role as a marker of NF-kappaB/p65 activation in the early embryo.
NF-kappaB has a role in increasing PDGF-B transcription
AIP1 is a novel transducer in TNF-induced TRAF2-dependent activation of ASK1 that mediates a balance between JNK versus NF-kappaB signaling
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
, NF-kappa-B inhibitor alpha
, major histocompatibility complex enhancer-binding protein MAD3
, nuclear factor of kappa light chain gene enhancer in B-cells
, I kappa B-alpha
, NF-kappaB inhibitor alpha
, REL-associated protein pp40
, Rel-associated pp40
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light polyp gene enhancer in B-cell 1
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha
, IkappaB alpha
, NF-kappaB inhibitor alpha-like protein A
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a