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Human Integrin beta 2 Protein expressed in HEK-293 Cells - ABIN2713476
De Franceschi, Peuhu, Parsons, Rissanen, Vattulainen, Salmi, Ivaska, Pouwels: Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. in PLoS ONE 2015
The ITGB2 variant rs2230531 was examined in an independent cohort of Tasmanian patients with hematologic malignancies (HM) to see if its presence correlated with chronic lymphocytic leukemia. The variant was found in several lymphoid and myeloid HMs (zeige CTSC Proteine), so if contributes to the risk of HM, it does so broadly across HM subtypes in this population.
Data suggest that the residue volume at phenylalanine (Phe) in alpha1-helix is critical for alpha(L)/beta(2) integrin (CD49a (zeige ITGA1 Proteine)/CD18) activation and binding with soluble/immobilized ICAM1 (zeige ICAM1 Proteine) (intercellular cell adhesion molecule 1 (zeige CADM1 Proteine)).
an integrated strategy of whole genome and transcriptome analysis enabled identification of LB-ITGB2-1 as HLA-B*15:01-restricted MiHAs encoded by an alternative transcript. The alternative ITGB2 transcript was shown to be expressed in leukemic cells of different origins.
Neutrophil rolling over E-selectin (zeige SELE Proteine) at precise shear stress transmits tension and catch-bond formation with L-selectin (zeige SELL Proteine) via sLe(x), resulting in focal clusters that deliver a distinct signal to upshift beta2-integrins to a high-affinity state. Rivipansel effectively blocked formation of selectin catch-bonds, revealing a novel mechanotransduction circuit
CD177 (zeige CD177 Proteine) signals in a beta2 integrin-dependent manner to orchestrate a set of activation-mediated mechanisms that impair human neutrophil migration.
Extracellular ISG15 (zeige ISG15 Proteine) signals cytokine secretion through the LFA-1 (zeige ITGAL Proteine) integrin receptor (CD11a (zeige ITGAL Proteine)/CD18) in natural killer cells.
findings suggest the partitioning in soluble CD18 to reflect a compensatory anti-inflammatory response syndrome and hyperinflammation, respectively, manifested as part of sepsis.
activation of LFA-1 (zeige ITGAL Proteine) (alphaLbeta2) and Mac-1 (zeige ITGAM Proteine) (alphaMbeta2), two subfamilies of integrin beta2 complexes, on human primary monocytes following platelet releasate treatment
data suggest that regulation of LFA-1 (zeige ITGAL Proteine) is one reason for the different activity of NK cells during differentiation
The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser (zeige SIGLEC1 Proteine) in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta (zeige YWHAZ Proteine) binding site that modulates integrin alphaM(PS)beta2 outside-in signaling
Data show CD18 is selectively required for T helper 2, but not T helper 1, homing and has a minimal influence on T-effector development.
Adhesive properties of the leukocyte integrin Mac-1 (zeige ITGAM Proteine) are not required for macrophage accumulation in adipose tissue. Instead, Mac-1 (zeige ITGAM Proteine) modulates inflammatory gene expression in macrophages.
in T cells, PI3Kdelta attenuates the activation of Rac1, but sustains the activation of Rap1.
An intracellular pool of LFA-1 (zeige ITGAL Proteine) in naive CD8 (zeige CD8A Proteine)(+) T cells plays a key role in T cell activation and differentiation.
CD18 deficiency curbs methionine-choline-deficient-mediated liver injury by limiting the activation of innate immune cells in the liver without compromising intrahepatic cytokine activation
results identify a role for Caveolin (Cav (zeige CA5A Proteine))1in membrane organization and beta2 integrin Lfa1 (zeige ITGAL Proteine) function in primary CD8 (zeige CD8A Proteine) T cells.
Coro1A (zeige CORO1A Proteine) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
These results identify CD47 (zeige CD47 Proteine) as an important regulator of LFA-1 (zeige ITGAL Proteine) and VLA-4 integrin-adhesive functions in T cell proliferation.
both GDF-15 (zeige GDF15 Proteine) and TGF-beta1 (zeige TGFB1 Proteine) counteract chemokine (zeige CCL1 Proteine)-induced integrin activation on neutrophils via the ALK-5 (zeige TGFBR1 Proteine)/TGF-betaRII heterodimer.
Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (zeige SELL Proteine) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (zeige CA2 Proteine)+]i, diminished annexin V (zeige ANXA5 Proteine) expression on the cell surface, and decreased caspase 3 (zeige CASP3 Proteine) activity in lysates
The I-EGF (zeige EGF Proteine)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (zeige ORM1 Proteine) and inhibited the chemotaxis of monocytes
Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Intact signal peptide of CD18, the beta-subunit (zeige POLG Proteine) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
CR3 (zeige ITGAM Proteine) plays a cardinal (zeige CARD8 Proteine) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
The expression of zona pellucida glycoprotein 3 (zeige ZP3 Proteine) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
early CD18 downregulation is profitable for the host in a situation with an intense LPS (zeige IRF6 Proteine) stimulus
It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.
Integrin CD11c (zeige ITGAX Proteine)/CD18 alpha-chain (zeige FCGRT Proteine) phosphorylation is functionally important.
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, complement receptor C3 beta-subunit
, complement receptor C3 subunit beta
, integrin beta chain, beta 2
, integrin beta-2
, leukocyte cell adhesion molecule CD18
, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
, Mac-1 beta
, lymphocyte function associated antigen 1
, macrophage antigen-1 beta
, CD18 subunit
, Leu-CAM receptor
, integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2)
, integrin beta 2 subunit
, CD18 leukocyte adhesion molecule
, antigen CD18
, integrin beta-2 chain
, integrin beta 2
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
, macrophage antigen 1 (mac-1) beta subunit)
, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, Complement receptor C3 subunit beta
, Integrin beta-2
, integrin beta-2 subunit
, integrin subunit beta 2 S homeolog
, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)