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Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2007346
Dinarello: Biologic basis for interleukin-1 in disease. in Blood 1996
Show all 6 Pubmed References
IL1A polymorphism rs2856838 may contribute to risk of colorectal cancer in Han Chinese population; rs3783550, rs1609682, rs3783521 seem to be pathogenic variants for colorectal cancer in females.
Neutrophil extracellular traps promote endothelial cell activation and increased thrombogenicity through concerted action of IL-1alpha and cathepsin G and tissue factor production.
IL-1alpha and not IL-1beta is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue
signaling driven by HER2 promotes chronic inflammation needed to support cancer stem-like cell maintenance in HER2-positive breast cancers
Study shows reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression.
these results suggested that the activation of the expression of S100A8 induced by IL1a in TR146 epithelial cells involves a mechanism by which the binding activity of C/EBPB to the specific site (113/109) of the S100A8 promoter is increased.
IL-1A (-889) gene polymorphism has a role in the pathogenesis of acne vulgaris. We suggest that the triggering or exacerbating effect of diet on acne may be related to IL-1A (-889) gene polymorphism.
Serum levels of IL-1alpha and IL12 were higher in cirrhotic than non -cirrhotic patients and higher in the diabetic patients. IL-1alpha and IL-12 are good markers for monitoring liver disease progression in cirrhotic and diabetic Hepatitis C patients.
The present study finds that IL-1 alpha -899C/T polymorphism is associated with the risk of intervertebral disc degeneration.
Inflammatory cytokines interleukin (IL)-1alpha, IL-1beta and interferon-gamma-induced protein (IP)-10 are biomarkers for detecting asymptomatic STIs and vaginal dysbiosis (bacterial vaginosis (BV) or intermediate microbiota).
IL1A (-889C/T: rs1800587:C > T, +4845G/T:rs17561G>T) and IL1B (-31C/T:rs1143627:T > C, -511C/T:rs16944C>T and +3954C/T:rs1143634:C > T) were genotyped through direct sequencing
Literature review suggests that for IL1B SNP rs1143634, EARR and CP have an opposite genetic profile. For IL1A SNP, our hypothesis could not be confirmed.
T allele of 4845G>T associated with male infertility
Interleukin-1 alpha (IL-1alpha) can be expressed by epithelial tumor cells, from which it is either secreted or released upon necrotic cell death [Review].
Based on the available data, C/T genotype of the rs1800587 polymorphism within IL1A gene may be associated with an increased Graves' disease risk.
IL-1 was positively related with increased BMI overweight and obesity
IL-1alpha is detectable in the majority of patients with infrarenal abdominal aortic aneurysms.
Meta-analysis suggests that the IL-1B rs16944 polymorphism is a susceptibility risk factor for febrile seizures in Caucasian and Asian populations. The IL-1B rs1143627, IL-1B rs1143634, and IL-1A rs1800587 polymorphisms are not associated with febrile seizure risk.
The IL-1b+3954 C/T polymorphism significantly increases RAS risk. In addition, the IL-10-1082 G/A polymorphism provided protective effects for RAS in the Asian population
The single nucleotide polymorphism (SNP) of IL-1beta gene (rs3917356G>A) increased the risk of HCC in the recessive model (p<0.001, OR=2.58, 95% CI=1.53-4.33), whereas other SNPs in IL-1alpha and IL-1RA showed no significant association between Hepatocellular carcinoma patients and controls.
IL-1 alpha/beta plays a positive role in muscle regeneration by coordinating the initial interactions among inflammatory microenvironments and satellite cells.
The alarmin IL-1alpha released upon ozone-induced tissue damage and inflammation is mediated by MyD88 signaling in epithelial cells.
IL-1alpha is required for a downstream signaling cascade of innate immunity for efficient clearance of Brucella
early Aspergillus fumigatus fungal conidium germination drives greater lung damage and IL-1alpha-dependent inflammation
High Il-1a expression is associated with inflammation.
Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1, and MMP1 in multinucleated macrophages.
Together, these data suggest that caspase-11/IL-1alpha pathway plays an important role in defending against Klebsiella pneumoniae by recruiting neutrophils in the early stage of infection.
These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr expression.
Following vasectomy, IL1alpha, IL1beta, IL1ra, IL10, and TNF-alpha may mediate immune reaction in whole epididymis, whereas IL6 and TGF-beta1 may mediate regionally different immune response primarily in the lower part of epididymis.
Since neither IL-1alpha nor IL-1beta depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta have a similar and probably complementary role in FHF progression
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
In response to chemically induced colitis, this microbial landscape promoted the release of IL-1alpha, which acted as a critical driver of colitis and colitis-associated cancer.
our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis.
Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.
endothelial cells were identified as the primary cellular source of G-CSF during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.
Key aspects of IL-1alpha biology and regulation especially with regard to inflammation are reviewed. Review.
data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1
IL-1alpha signaling and DNA damage is important for triggering a sterile inflammatory cascade .
As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.
Constitutive suppression of IL-1alpha maintains quiescence of endothelium and that terminal complement complexes remove that suppression, allowing IL-1alpha transcription and, ultimately, activation of endothelium to proceed.
These findings suggest that the elevated levels of IL-1alpha found in the osteoarthritis environment heighten fibroblast-like synoviocytes sensitivity to fluid shear by altering both intercellular communication and individual cell sensitivity, which could affect downstream functions and contribute to progression of the disease state
Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.
Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF(2alpha) and PGE(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
These results suggest that IL-1alpha and IL-1beta are produced by the stromal cells, that IL-1beta is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen activator in bovine endometrial cells.
We propose that induction of collagenase-1 by IL-1alpha in both WF and NF depends on a unique combination of cell type-specific signaling pathways.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
, interleukin-1 alpha
, preinterleukin 1 alpha
, interleukin 1 alpha
, interleukin 1-alpha
, precursor interleukin 1 alpha
, Interleukin-1 alpha
, precursor interleukin-1alpha