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Human AMH Protein expressed in HEK-293 Cells - ABIN2714759
Signorile, Petraglia, Baldi: Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis in endometriosis cells. in Journal of experimental & clinical cancer research : CR 2014
Gdf9 (zeige GDF9 Proteine) significantly suppressed the expression of amh while increased that of activin beta subunits (inhbaa (zeige INHBA Proteine) and inhbb (zeige INHBB Proteine)) in vitro.
These data suggest that an important aspect of Fsh (zeige BRD2 Proteine) bioactivity in stimulating spermatogenesis is implemented by restricting the different inhibitory effects of Amh and by counterbalancing them with stimulatory signals, such as Igf3.
amh controls the balance between proliferation and differentiation of male germ cells.
nuclear receptor subfamily 5, group A, member 1b is a new candidate for sex determination and differentiation in a way similar to steroidogenic factor 1 (zeige NR5A1 Proteine), possibly involving AMH
zebrafish Anti-Mullerian hormone (Amh) is regulated by sox9a, sox9b, and cyp19a1a during gonad development
amh is a candidate gene down-regulating cyp19a1a, leading to "juvenile ovary-to-testis" transformation.
It was shown that the male-to-female sex reversal phenotype in hotei medaka mutants is not a direct consequence of anti-Mullerian hormone signaling in supporting cells, but is instead mediated by germ cells.
AMH is a poor independent predictor of live birth outcome in either fresh or frozen embryo transfer.
AMH, IGF1 (zeige IGF1 Proteine) and leptin (zeige LEP Proteine) levels in follicular fluid have no relation to the fertility disorders caused by endometriosis or fallopian tube damage, though they are biomarkers for anovulatory fertility disorders.
serum levels between women with insulin (zeige INS Proteine) resistance and without insulin (zeige INS Proteine) resistance in polycystic ovary syndrome were not significantly different
Data suggest that serum levels of AMH are down-regulated during second half of gestation in (1) women with gestational diabetes, (2) pregnant women with type 2 diabetes, and (3) control pregnant women. A positive association between AMH and testosterone levels was observed in all groups. Also, serum AMH levels are negatively associated with maternal age in the population studied.
Data confirm that serum levels of AMH decline as function of age (not menstrual cycle) in women ages 20-50; here, results of ELISA assays of serum levels of AMH vary according to kit used. These studies were conducted at a fertility clinic in Poland; serum AMH is proposed as biomarker for ovarian reserve.
AMH single nucleotide polymorphism is associated with Endometriosis-associated infertility.
This study demonstrated the existence of an AMH-FOXL2 (zeige FOXL2 Proteine) relationship in hGCs. AMH is capable of increasing both gene and protein expression of FOXL2 (zeige FOXL2 Proteine). Because FOXL2 (zeige FOXL2 Proteine) induces AMH transcription, these ovarian factors could be finely regulated by a positive feedback loop mechanism to preserve the ovarian follicle reserve.
Data suggest that circulating AMH influences development of human brain; high levels of circulating AMH are unique to developing boys; here, boys age 5-6 years exhibit up-regulation of circulating AMH but are delayed in maturity index (judged by drawings) as compared to girls age 5-6 years. This study was conducted in New Zealand.
The combination of GDF9 (zeige GDF9 Proteine) + BMP15 (zeige BMP15 Proteine) potently stimulates AMH expression in primary cumulus cells.
Surface plasmon resonance analysis showed no significant association between FS288 and AMHC (zeige MYH6 Proteine) , suggesting that FS288 indirectly regulates AMH signaling. Activin A (zeige INHBA Proteine), a direct target of FS288, did not itself induce reporter activity in P19 (zeige CDKN2D Proteine) cells, but did prevent the FS288-induced increase in AMH signaling. Hence, local concentrations of FS288 and Activin A (zeige INHBA Proteine) may influence the response of some cell types to AMH.
These results suggest that AMH acts on the Mullerian duct in male mice by exuding into the interstitium surrounding the testis cord and infiltrating through the cranial region from the testis to the mesonephros.
AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons.
AMH and FOXL2 (zeige FOXL2 Proteine) collaboratively work to reserve ovarian follicles. AMH is an endogenous target gene of FOXL2 (zeige FOXL2 Proteine).
Up-regulation of SOX9 (zeige SOX9 Proteine) in sertoli cells from testiculopathic patients accounts for increasing anti-mullerian hormone expression via impaired androgen receptor (zeige AR Proteine) signaling.
Male mice require AMH to undergo normal social development.
Data show that Purkinje cells express receptors for Mullerian inhibiting substance (MIS), and that MIS(-/-) male mice have female-like numbers of Purkinje cells and a female-like size to other parts of their cerebellum.
MIS may be involved in anterograde rather than autocrine or retrograde regulation of neurons.
FSH (zeige BRD2 Proteine) and cAMP stimulate AMH transcription by granulosa cells. FSH (zeige BRD2 Proteine) and LH have an additive effect, which may be important in polycystic ovary syndrome.
This suggests that MIS is one of the determinants of "boy"-specific behavior.
Anti-Mullerian hormone inhibits activation and growth of bovine ovarian follicles in vitro and is localized to growing follicles.
This study showed that antral follicle counts (AFC) and AMH levels were repeatable when determined at an unknown stage of follicular growth and expected day of follicular wave emergence, but repeatability was greater for AMH than AFC.
The effects of castration and other surgical intervention on the blood levels of anti-Muellerian hormone, inhibin A (zeige INHA Proteine), gonadotropins, and gonadotropin receptors in bull calves are reported.
Results from these studies indicate that AMH signaling plays a role in both regulating granulosa cell proliferation and preventing granulosa cells from 5- to 8-mm follicles from undergoing premature differentiation before follicle selection.
These findings indicate the followings: AMH mRNA levels decrease in both dominant and secondary follicles during follicular deviation; granulosa cells from heathy follicles express more AMH mRNA compared to subordinate follicles undergoing atresia and FSH (zeige BRD2 Proteine) stimulates AMH and AMHR2 (zeige AMHR2 Proteine) mRNA expression in granulosa cells of co-dominant follicles.
Measurement of AMH concentration in the plasma of cows can help to predict their capacity for embryo production in response to gonadotrophin treatment.
In first study to investigate the blood profile and immunohuistochemistry of anti-Mullerian hormone in bovine granulosa-theca cell tumors, the findings indicated that anti-Mullerian hormone is a novel biomarker for granulosa-theca cell tumors in cattle.
Regulation of anti-Mullerian hormone production in the cow.
Intrafollicular AMH was not a marker of cystic development in the cow, but low AMH concentrations in cysts were associated with luteinization.
AMH expression is modulated by androgens in bovine granulosa cells from small follicles.
Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome.
, anti-Mullerian hormone
, anti-mullerian hormone
, Mullerian inhibiting factor
, Mullerian inhibiting substance
, anti-Muellerian hormone
, muellerian-inhibiting substance
, Mullerian inhibitory substance
, Anti - Mullerian hormone (Mulerian inhibiting substance)