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STMN1 expression was higher in basal-type cell lines than in luminal-type cell lines, and overall survival and post-progression survival in the high STMN1 expression breast cancer patients were shorter than in low STMN1 expression patients. High STMN1 expression is a possible marker of breast cancer aggressiveness in association with proliferation, phenotype and cancer stem cell type
we found upregulated expression of STMN1 in the atypical/anaplastic meningioma group, relative to that in the benign meningioma group. STMN1, therefore, is a promising target to improve cure rates in meningioma cases.
An increased risk of sporadic atypical meningioma recurrence can be found in cases with elevated expression of STMN1.
The miR (zeige MLXIP Proteine)-34a/STMN1/betaIII-tubulin (zeige TUBB3 Proteine) axis maintains the microtubule cytoskeleton in osteosarcoma, and combining miR (zeige MLXIP Proteine)-34a with microtubule inhibitors can be investigated as a novel therapeutic strategy.
These findings suggest that Cdc2 (zeige CDK1 Proteine) is positively associatd with the development of taxol resistance. The Cdc2 (zeige CDK1 Proteine) inhibitor, purvalanol A, enhanced the cytotoxic effects of taxol through Op18/stathmin.
these results showed that stathmin expression was significantly up-regulated in LAC (zeige LCT Proteine), which may act as a biomarker for LAC (zeige LCT Proteine). Furthermore, silence of stathmin inhibiting LAC (zeige LCT Proteine) cell growth indicated that stathmin may be a promising molecular target for LAC (zeige LCT Proteine) therapy.
Increased stathmin correlated with pathologic grade, lymphatic invasion, advanced stage and poor survival of non-small cell lung cancer (NSCLC), which indicated that stathmin could serve as a potential biomarker of NSCLC
Results showed that patients with cancer displayed a higher stathmin expression than those of non-cancer individuals, and overexpression of stathmin correlated with tumor cell differentiation, lymph node invasion and high TNM (zeige ODZ1 Proteine) stage. [review]
High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Pancreatic Cancer.
miR (zeige MLXIP Proteine)-223 might serve as an onco-suppressor that enhances susceptibility to docetaxel by downregulating STMN1 in gallbladder cancer, highlighting its promising therapeutic value.
The data suggest that STMN1 mediates the progesterone production by modulating the promoter activity of Star and Cyp11a1 (zeige CYP11A1 Proteine).
EGFR (zeige EGFR Proteine) suppression of mitotic regulators including Rcc2 (zeige RCC2 Proteine) and Stathmin 1 are a mechanism for catagen induction in mouse skin
We identified stathmin as a key molecule aiding in septin (zeige SEPT6 Proteine)-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7 (zeige SEPT7 Proteine)-null fibroblasts
Overexpressing stathmin reduces complement receptor 3 (zeige ITGAM Proteine)-mediated phagocytosis and cellular activation, implicating a pivotal inhibitory role for stathmin in classically activated macrophages.
Stathmin cooperates with p27(kip1 (zeige CDKN1B Proteine)) to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression.
The protein profiles during murine embryo implantation were clarified. Stathmin 1 might be a potential regulator of embryo implantation.
Results show an important role for stathmin during adult neurogenesis in the subgranular zone of the mouse hippocampus; propose that stathmin controls the transition from neuronal precursors to early postmitotic neurons
Stathmin mutations disrupt changes in microtubule stability, GluA2 (zeige GRIA2 Proteine) localization, synaptic plasticity and memory.
Stmn deletion does not prolong the lifespan of spinal muscular atrophy-like mice, suggesting that stathmin dysregulation and microtubule disruption are not a cause but rather a consequence of SMA (zeige SMN1 Proteine) pathology.
stathmin expression is dispensable for tumor onset, at least in mice, thus making stathmin a virtually exclusive marker of aggressive disease and a promising therapeutic target for advanced cancers.
Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle.
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.
leukemia-associated phosphoprotein p18
, oncoprotein 18
, phosphoprotein 19
, phosphoprotein p19
, stathmin 1/oncoprotein 18
, transmembrane protein C1orf215
, leukemia associated phosphoprotein p18
, leukemia-associated gene protein
, leukemia-associated cytosolic phosphoprotein stathmin
, stathmin 1 a
, stathmin 1/oncoprotein 18b
, stathmin 1
, stathmin 1 b
, stathmin 1b
, stathmin clone XO35