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the suppression of Nrf2 (zeige NFE2L2 Proteine) attenuates adipogenesis and decreases FGF21 (zeige FGF21 Proteine) expression through PPARgamma in 3T3-L1 cells.
data demonstrated that reduction of Pparg expression in T-helper cells is critical for spontaneous SLE-like autoimmune disease development; we also revealed a novel function of PPARgamma in lymphocyte trafficking and cross talk between Th17 and B cells.
the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein alpha (C/EBPa (zeige CEBPA Proteine)), CCAAT enhancer-binding protein beta (C/EBPb (zeige CEBPB Proteine)), and gamma receptors by peroxisome proliferators (PPARg), during adipogenesis
these findings identified an important role of renal tubular epithelium-targeted PPAR-gamma in maintaining the normal epithelial phenotype and opposing fibrogenesis, possibly via antagonizing oxidative stress
Activation of PPARgamma in hematopoietic stem cells impaired hematopoietic repopulation. PPARgamma inhibition by shRNA or chemical compounds significantly improves the repopulating ability of Fancd2-/- HSCs.
Study found that the metabolic master regulator PGC-1alpha is differentially affected by ALS-associated mutations in brain vs. peripheral tissues. Increased PGC-1alpha activity in peripheral tissue contributes to the metabolic phenotype, while in the CNS blunting of the PGC-1alpha response renders motoneurons vulnerable.
DBZ is a putative PPARgamma agonist that prevents HFD-induced obesity-related metabolic syndrome and reverse gut (zeige GUSB Proteine) dysbiosis. DBZ may be used as a beneficial probiotic agent to improve HFD-induced obesity-related metabolic syndrome in obese individuals
Altogether, the authors demonstrate that Dnmt3a (zeige DNMT3A Proteine) and Dnmt3b (zeige DNMT3B Proteine) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma.
FBXO9 (zeige FBXO9 Proteine) directly interacted with PPAR gamma through the activation function-1 domain and ligand-binding domain. FBXO9 (zeige FBXO9 Proteine) decreased the protein stability of PPAR gamma through induction of ubiquitination.
inhibition of Hsp90 (zeige HSP90 Proteine) in Sec61a1 (zeige SEC61A1 Proteine) mutant hepatocytes also reduced Ppargamma protein levels and signaling.
Findings suggest that despite their proposed involvement in the regulation of inflammatory processes in multiple sclerosis (MS), PPARalpha (zeige PPARA Proteine), PPARbeta (zeige PPARD Proteine)/delta, and PGC-1alpha proteins are not potential biomarkers of neuroinflammation in MS, and indicate a preferential role of PPARgamma in the endogenous regulation of autoimmune response in the human central nervous system within its receptor family.
combined administration of small-interfering RNA (siRNA) transfection with PPARgamma ligands induced downregulation of SOX2 (zeige SOX2 Proteine) and MMP2 (zeige MMP2 Proteine) activity together with inhibition of sphere-forming activity regardless of poly(ADP-ribose) polymerase (PARP (zeige PARP1 Proteine)) cleavage. Taken together, our findings suggest that a combination therapy using PPARgamma ligands and its inhibitor could be a potential therapeutic strategy targeting glioblastom...
High concentrations of DINCH urinary metabolites activate human PPAR-gamma.
UCP2 (zeige UCP2 Proteine) is a key mediator of hypoxia-triggered chemoresistance in non-small cell lung cancer cells via repression of peroxisome proliferator-activated receptor gamma.
MERS-CoV S protein (zeige CDSN Proteine) binds to DPP4 (zeige DPP4 Proteine) to suppress macrophage activation via induction of IRAK-M (zeige IRAK3 Proteine), PPARgamma and the immunosuppressive cytokine IL-10 (zeige IL10 Proteine).
our findings provide novel insights into the role of PPARgamma in inhibiting breast cancer progression
Results demonstrate that phosphorylation of PPARgamma at Ser84 is up-regulated in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) tumors. The study provides the first evidence that the novel roles of PPARgamma are linked to glycolysis by PFKFB4 (zeige PFKFB4 Proteine) for the regulation of glycolysis and proliferation in HCC (zeige FAM126A Proteine) cells.
These results indicated that AKT (zeige AKT1 Proteine)-PPARgamma signaling pathway mediated HG-induced lipid deposition by upregulating CD36 (zeige CD36 Proteine) expression in HK-2 (zeige HK2 Proteine) cells and that inhibition of AKT (zeige AKT1 Proteine)-PPARgamma signaling pathway had the potential beneficial effects of reducing lipid deposition in diabetic kidney.
Consumption of a high-fat, high-calorie meal is associated with an increase in intracellular co-localization of PPARgamma mRNA and protein in monocytes.
The results suggest the higher expression of miR (zeige MYLIP Proteine)-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (zeige FRAP1 Proteine) and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 (zeige IGF1 Proteine) secretion and gene expression in response to dietary protein.
The regulatory role of microRNA miR (zeige MYLIP Proteine)-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR (zeige MYLIP Proteine)-27b-3p]
an Enhancer box and a binding site for a cooperative co-activator of MyoD (zeige MYOD1 Proteine) are present in the promoter region of porcine PPARgamma.
The data suggest that there is local cooperation between resistin (zeige RETN Proteine) and PPARgamma expression in the porcine ovary. Resistin (zeige RETN Proteine) significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin (zeige RETN Proteine) expression; thus, PPARgamma is a new key regulator of resistin (zeige RETN Proteine) expression and function.
Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (zeige MSTN Proteine) in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD (zeige MYOD1 Proteine) expression.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK (zeige MAPK1 Proteine) activation mediated PPARgamma phosphorylation.
Resveratrol activated sirtuin 1 (Sirt1 (zeige SIRT1 Proteine)) gene expression and increased adipose triglyceride lipase (ATGL (zeige PNPLA2 Proteine)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (zeige SIRT1 Proteine) regulation pattern for PPARgamma to that of ATGL (zeige PNPLA2 Proteine) in adipocytes.
The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.
Increasing dietary DE linearly enhanced the expression of PPARgamma in adipose tissues but not skeletal muscle of Rongchang piglets.
Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB (zeige NFKB1 Proteine) activation through a mechanism partly dependent on PPARgamma activation.
PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.
An Asp7Gly substitution in PPARG is associated with adiposity.
upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta (zeige CEBPB Proteine) and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 (zeige FFAR2 Proteine) gene expression in adipocytes.
A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.
study demonstrates the co-expression of DLX3 (zeige DLX3 Proteine), PPARG and SP1 (zeige SP1 Proteine) in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.
oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells
study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP (zeige PTPN2 Proteine), only the lesioned putamen had increased PPAR-gamma
Aleglitazar, a dual PPARalpha (zeige PPARA Proteine)/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.
vitamin E supplementation affords protection by decreasing MMP-1 (zeige MMP1 Proteine) and increasing PPARg, GSTa (zeige GSTa2 Proteine), and ABCA1 (zeige ABCA1 Proteine) levels in aortae of rabbits fed a cholesterol-rich diet
Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.
PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 (zeige PTGS2 Proteine) down-regulation and 3beta-HSD (zeige HAL Proteine) up-regulation, with a consequent PGF2alpha decrease and progesterone increase.
In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.
Tongxinluo can inhibit the expression of MMP-3 (zeige MMP3 Proteine) and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
Niacin Reduces serum level and adipose mRNA expression of leptin (zeige LEP Proteine) and up-regulates PPARgamma and CD36 (zeige CD36 Proteine) mRNA expression in hypercholesterolemic rabbits.
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase (zeige PIK3CA Proteine), Akt (zeige AKT1 Proteine), and eNOS (zeige NOS3 Proteine) pathway in a rabbit model of myocardial infarction.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
peroxisome proliferator activated receptor gamma
, peroxisome proliferative activated receptor gamma
, peroxisome proliferator-activated receptor gamma
, peroxisome proliferator activator receptor gamma
, nuclear receptor subfamily 1 group C member 3
, peroxisome proliferator activated receptor gamma 2
, peroxisome proliferator activated receptor gamma 4
, Nuclear receptor subfamily 1 group C member 3
, PPAR gamma
, peroxisome proliferator-activated nuclear receptor gamma variant 1
, peroxisome proliferator-activated receptor gamma 1
, peroxisome proliferator activator receptor, gamma
, PPAR gamma 2
, xPPAR gamma
, peroxisome proliferative activated receptor, gamma
, peroxisome proliferator-activated receptor gamma 2
, peroxisome proliferator-activated receptor gamma 1-a
, peroxisome proliferator-activated receptor gamma 1-b
, PPAR gamma 1
, peroxisome proliferator activated receptor gamma-1
, peroxisome proliferator-activated receptor-gamma