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Our results found that, in the mice with T2D and AD, the activators of PPARg/AMPK (zeige PRKAA1 Proteine) signaling pathway significantly increased the expression level of IDE (zeige IDE Proteine), and decreased the accumulation of Ab40 and Ab42, as well as alleviated the spatial learning and recognition impairments.
PPARgamma functions as a checkpoint, guarding against inflammation, and is permissive for alternative activation of macrophages by facilitating glutamine metabolism
Inhibition of this phosphorylation results in deregulation of p53 signaling, and biochemical studies show that PPARgamma physically interacts with p53 in a manner dependent on S273 phosphorylation.
Direct regulation of mitochondrially encoded electron transport chain gene expression by mitochondrial PPARgamma2, in part, underlies the isoform-specific role for PPARgamma2 in brown adipocytes.
L-Carnitine alleviated epithelial mesenchymal transformation-associated renal fibrosis caused by perfluorooctanesulfonate through a Sirt1 (zeige SIRT1 Proteine)- and PPARgamma-dependent mechanism.
Pgc-1beta (-/-) hearts show pro-arrhythmic instabilities attributable to altered action potential conduction and activation rather than recovery characteristics.
CACUL1 reciprocally regulates SIRT1 (zeige SIRT1 Proteine) and LSD1 (zeige KDM1A Proteine) to repress PPARgamma and inhibit adipogenesis.
results support a stimulatory effect of Pb on adipogenesis which involves ERK (zeige EPHB2 Proteine) activation and C/EBPbeta (zeige CEBPB Proteine) upregulation prior to PPARgamma and adipogenesis activation.
Overexpressing STAMP2 (zeige STEAP4 Proteine) attenuates adipose tissue angiogenesis and insulin (zeige INS Proteine) resistance in diabetic ApoE (zeige APOE Proteine)(-/-) /LDLR (zeige LDLR Proteine)(-/-) mouse via a PPARgamma/CD36 (zeige CD36 Proteine) pathway.
demonstrate that chronic ethanol ingestion activates peroxisome proliferator-activated receptor gamma (PPARgamma) and its target gene, monoacylglycerol O-acyltransferase 1 (MGAT1 (zeige MOGAT1 Proteine))
participation rates in the genotype-based recall study were 31%, 44%, and 40%, and accordingly we included 12, 15, and 13 individuals with Pro12Pro, Pro12Ala, and Ala12Ala variants of PPARG, respectively
Here we have shown for the first time, that ligand- or insulin (zeige INS Proteine)-mediated activation of PPARgamma in human hepatoma cell line HepG2 causes the downregulation of C3 gene expression and protein secretion
Interactions between SOD2 (zeige SOD2 Proteine) and PPAR-gamma SNPs regarding mortality influence were detected in diabetic ESRD patients.
Data suggest that up-regulation of NPY (zeige NPY Proteine) inhibits proliferation of adipose-derived stem cells while promoting adipogenesis and up-regulating expression of white adipocyte biomarkers PPARG, CEBPA (zeige CEBPA Proteine), CIDEC (zeige CIDEC Proteine), and RIP140 (zeige NRIP1 Proteine). (NPY (zeige NPY Proteine) = neuropeptide Y (zeige NPY Proteine); CEBPA (zeige CEBPA Proteine) = CCAAT/enhancer-binding protein alpha (zeige CEBPA Proteine); CIDEC (zeige CIDEC Proteine) = cell death-inducing DFFA-like effector C (zeige CIDEC Proteine); RIP140 (zeige NRIP1 Proteine) = nuclear receptor interacting protein 1 (zeige NRIP1 Proteine))
The presence of Pro12Pro and C14131C genotypes is related to higher TAG level in CTD.
Low PPARG expression is associated with childhood obesity.
The results propose that PPARgamma may act as a master regulator of the transcription of several genes involved in late-onset Alzheimer's disease pathogenesis.
Polymorphism of PPARG is associated with late onset of type 2 diabetes mellitus.
PPARgamma gene rs2921190 polymorphism was correlated with the susceptibility to northwest dryness syndrome.
Phosphorylation of S273 of PPARgamma occurs in cancer cells on exposure to DNA damaging agents.
The results of the present study suggested that PPARG may mediate porcine placental angiogenesis, by interfering with hypoxia inducible factor, vascular endothelial growth factor (zeige VEGF Proteine) and angiopoietinmediated signaling.
The results suggest the higher expression of miR (zeige MYLIP Proteine)-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (zeige FRAP1 Proteine) and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 (zeige IGF1 Proteine) secretion and gene expression in response to dietary protein.
The regulatory role of microRNA miR (zeige MYLIP Proteine)-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR (zeige MYLIP Proteine)-27b-3p]
an Enhancer box and a binding site for a cooperative co-activator of MyoD (zeige MYOD1 Proteine) are present in the promoter region of porcine PPARgamma.
The data suggest that there is local cooperation between resistin (zeige RETN Proteine) and PPARgamma expression in the porcine ovary. Resistin (zeige RETN Proteine) significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin (zeige RETN Proteine) expression; thus, PPARgamma is a new key regulator of resistin (zeige RETN Proteine) expression and function.
Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (zeige MSTN Proteine) in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD (zeige MYOD1 Proteine) expression.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK (zeige MAPK1 Proteine) activation mediated PPARgamma phosphorylation.
Resveratrol activated sirtuin 1 (Sirt1 (zeige SIRT1 Proteine)) gene expression and increased adipose triglyceride lipase (ATGL (zeige PNPLA2 Proteine)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (zeige SIRT1 Proteine) regulation pattern for PPARgamma to that of ATGL (zeige PNPLA2 Proteine) in adipocytes.
The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.
Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB (zeige NFKB1 Proteine) activation through a mechanism partly dependent on PPARgamma activation.
PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.
An Asp7Gly substitution in PPARG is associated with adiposity.
upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta (zeige CEBPB Proteine) and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 (zeige FFAR2 Proteine) gene expression in adipocytes.
A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.
study demonstrates the co-expression of DLX3 (zeige DLX3 Proteine), PPARG and SP1 (zeige SP1 Proteine) in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.
oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells
study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP (zeige PTPN2 Proteine), only the lesioned putamen had increased PPAR-gamma
Aleglitazar, a dual PPARalpha (zeige PPARA Proteine)/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.
vitamin E supplementation affords protection by decreasing MMP-1 (zeige MMP1 Proteine) and increasing PPARg, GSTa (zeige GSTa2 Proteine), and ABCA1 (zeige ABCA1 Proteine) levels in aortae of rabbits fed a cholesterol-rich diet
Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.
PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 (zeige PTGS2 Proteine) down-regulation and 3beta-HSD (zeige HAL Proteine) up-regulation, with a consequent PGF2alpha decrease and progesterone increase.
In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.
Tongxinluo can inhibit the expression of MMP-3 (zeige MMP3 Proteine) and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
Niacin Reduces serum level and adipose mRNA expression of leptin (zeige LEP Proteine) and up-regulates PPARgamma and CD36 (zeige CD36 Proteine) mRNA expression in hypercholesterolemic rabbits.
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase (zeige PIK3CA Proteine), Akt (zeige AKT1 Proteine), and eNOS (zeige NOS3 Proteine) pathway in a rabbit model of myocardial infarction.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
peroxisome proliferator activated receptor gamma
, peroxisome proliferative activated receptor gamma
, peroxisome proliferator-activated receptor gamma
, peroxisome proliferator activator receptor gamma
, nuclear receptor subfamily 1 group C member 3
, peroxisome proliferator activated receptor gamma 2
, peroxisome proliferator activated receptor gamma 4
, Nuclear receptor subfamily 1 group C member 3
, PPAR gamma
, peroxisome proliferator-activated nuclear receptor gamma variant 1
, peroxisome proliferator-activated receptor gamma 1
, peroxisome proliferator activator receptor, gamma
, PPAR gamma 2
, xPPAR gamma
, peroxisome proliferative activated receptor, gamma
, peroxisome proliferator-activated receptor gamma 2
, peroxisome proliferator-activated receptor gamma 1-a
, peroxisome proliferator-activated receptor gamma 1-b
, PPAR gamma 1
, peroxisome proliferator activated receptor gamma-1
, peroxisome proliferator-activated receptor-gamma