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anti-Human MAPK6 Antikörper:
anti-Rat (Rattus) MAPK6 Antikörper:
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Rat (Rattus) Monoclonal MAPK6 Primary Antibody für BI, IF - ABIN967749
Clark, Hynes: Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. in The Journal of biological chemistry 1996
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Human Monoclonal MAPK6 Primary Antibody für FACS, ELISA - ABIN966092
Déléris, Rousseau, Coulombe, Rodier, Tanguay, Meloche: Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. in Journal of cellular physiology 2008
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Human Monoclonal MAPK6 Primary Antibody für FACS, ELISA - ABIN969115
Klinger, Turgeon, Lévesque, Wood, Aagaard-Tillery, Meloche: Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK (zeige PRKAA1 Antikörper)/p38 MAPK (zeige MAPK14 Antikörper)-ERK3 (zeige MAPK4 Antikörper)/mTORC1 pathways. ERK3 (zeige MAPK4 Antikörper) is a newfound potential prognostic predictor and a tumor suppressor in ICC.
Study revealed a post-translational regulation of TDP2 (zeige TDP2 Antikörper) activity and discovered a new role of ERK3 (zeige MAPK4 Antikörper) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (zeige TOP2A Antikörper) inhibitors.
MAPK6 could rescue the cell growth induced by miR499a and HBV
ERK3 (zeige MAPK4 Antikörper) regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3 (zeige NCOA3 Antikörper)/SP-1 (zeige PSG1 Antikörper)-mediated VEGFR2 (zeige KDR Antikörper) expression.
These findings further expand distinct roles of cyclin D3 (zeige CCND3 Antikörper) and suggest the potential activity of ERK3 (zeige MAPK4 Antikörper) in cell proliferation.
Cdc14A (zeige CDC14A Antikörper) forms a stable complex with atypical mitogen-activated protein kinase (zeige MAPK1 Antikörper) Erk3 (zeige MAPK4 Antikörper) in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain.
identify the Erk3 (zeige MAPK4 Antikörper) protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK (zeige MAPK1 Antikörper) signaling.
A previously unknown role for ERK3 (zeige MAPK4 Antikörper) in promoting lung cancer cell invasiveness by phosphorylating SRC-3 (zeige NCOA3 Antikörper) and regulating SRC-3 (zeige NCOA3 Antikörper) proinvasive activity by site-specific phosphorylation.
ERK3 (zeige MAPK4 Antikörper) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 (zeige CDKN1A Antikörper) but not that of substrates ubiquitinated on internal lysine residues.
ERK3 (zeige RYK Antikörper) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular-regulated kinase 3 (ERK3 (zeige RYK Antikörper)) specifically interacts with the MAPK-activated protein kinase 5 (MK5 (zeige MAPKAPK5 Antikörper) or PRAK (zeige MAPKAPK5 Antikörper)) in vitro and in vivo.
Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5 (zeige MAPKAPK5 Antikörper)).
p38gamma (zeige MAPK12 Antikörper) MAP kinase (zeige MAPK1 Antikörper) (SAPK3/p38gamma (zeige MAPK12 Antikörper)) was shown to catalyse phosphorylation of SAP97 (zeige DLG1 Antikörper).
Results show that Cdo (zeige CDO1 Antikörper) is important for full Abl kinase activity, and Abl (zeige ABL1 Antikörper) is necessary for full activation of p38 MAPK (zeige MAPK14 Antikörper), during myogenic differentiation.
Genetic and biochemical evidences not only show that MEK1 (zeige MAP2K1 Antikörper)-MPK6 cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1 (zeige MAP2K1 Antikörper)-MPK6 cascade functions via working downstream of H2O2 and upstream of NO.
that MPK3 (zeige MAPK3 Antikörper)/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF (zeige CEBPZ Antikörper) expression and freezing tolerance in plants
BASL polarization leads to elevated nuclear MPK6 signaling and lowered SPCH abundance in one of the two daughter cells. Therefore, two daughter cells are differentiated by BASL polarity-mediated differential suppression of SPCH, which may provide developmental plasticity in plant stem cell asymmetric cell division.
results indicated that AIK1-MKK5 (zeige MAP2K5 Antikörper)-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (zeige MAPK1 Antikörper) cascade.
MPK6 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3 (zeige MAPK3 Antikörper)/MPK6 cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
MPK6-mediated regulation of MYB15 plays an important role in cold stress signaling in Arabidopsis.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 (zeige MAPK3 Antikörper) and MPK6 can both interact with SPOROCYTELESS/NOZZLE (SPL (zeige SGPL1 Antikörper)) in vitro and in vivo and can phosphorylate the SPL (zeige SGPL1 Antikörper) protein in vitro.
AIK1-MKK5 (zeige MAP2K5 Antikörper)-MPK6 cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
, MAP kinase 6
, MAP kinase isoform p97
, MAPK 6
, extracellular signal-regulated kinase 3
, extracellular signal-regulated kinase, p97
, protein kinase, mitogen-activated 5
, protein kinase, mitogen-activated 6
, Erk-3 related
, mitogen activated protein kinase 4
, mitogen activated protein kinase 6
, protein kinase, mitogen activated kinase 4
, extracellular related kinase 3
, mitogen-activated protein kinase 6