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Apocynin may act as a novel molecular candidate to protect against vascular smooth muscle cell osteogenic switching/vascular calcification through suppressing ERK1/2 pathway.
GHRH agonist MR-409 increase phosphorylation of AKT and ERK1/2 in dermal fibroblasts.
telomere stability is under direct control of one of the major pro-oncogenic signaling pathways (RAS/RAF (zeige RAF1 Proteine)/MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine)) via TRF2 (zeige TERF2 Proteine) phosphorylation.
Data suggest that inability of lithium, an anti-manic agent, to regulate circadian rhythms in cells from patient with bipolar disorder reflects reduced ERK1/2 activity and MAP kinase (zeige MAPK1 Proteine) signaling through ELK1 (zeige ELK1 Proteine). (ERK (zeige EPHB2 Proteine) = extracellular signal-related kinase; ELK1 (zeige ELK1 Proteine) = ETS-domain protein (zeige ELK3 Proteine) ELK1 (zeige ELK1 Proteine))
Report differential expression of EZH2 (zeige EZH2 Proteine) protein in small cell and aggressive B-cell non-Hodgkin lymphomas and differential regulation of EZH2 (zeige EZH2 Proteine) expression by p-ERK1/2 and MYC (zeige MYC Proteine) in aggressive B-cell lymphomas.
Data indicate that PD0325901 inhibited extracellular signal-regulated kinases ERK1/2 phosphorylation.
Findings suggest that ERK1/2-mediated Cdk2 (zeige CDK2 Proteine)/cyclin A (zeige CCNA2 Proteine) signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
Endoplasmic reticulum stress contributes to nefazodone-induced toxicity in HepG2 cells and ERK1/2 signaling pathway plays an important role.
ERK1 Directly Interacts With JNK1 (zeige MAPK8 Proteine) Leading to Regulation of JNK1 (zeige MAPK8 Proteine)/c-Jun (zeige JUN Proteine) Activity and Cell Transformation.
egulation of apoptosis was far more sensitive than regulation of proliferation. IGF1 (zeige IGF1 Proteine) and insulin (zeige INS Proteine) activated PKB (Akt/PKB (zeige AKT1 Proteine)) rapidly and consistently maintained its phosphorylation. Activation of ERK1/2 was only observed in response to IGF1 (zeige IGF1 Proteine).
Betacellulin (zeige BTC Proteine) promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1/Erk2 (zeige MAPK1 Proteine).
North American ginseng inhibits myocardial NOX2 (zeige CYBB Proteine)-ERK1/2-TNF-alpha (zeige TNF Proteine) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (zeige GFAP Proteine)-positive astrocytes for normal neurodevelopment.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 or Erk2 (zeige MAPK1 Proteine) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (zeige CD44 Proteine) expression, and increased CD44 (zeige CD44 Proteine) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (zeige ICAM1 Proteine) and VCAM-1 (zeige VCAM1 Proteine) by activating the ERK1/2 pathway, resulting in the expression of ETB (zeige EDNRB Proteine) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (zeige NFkBP65 Proteine), ERK1, ERK2 (zeige MAPK1 Proteine) and STAT1 (zeige STAT1 Proteine) pathways.
MAPK3/1 participates in primordial follicle activation through mTORC1-KITL (zeige KITLG Proteine) signaling.
At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway.
ERK1/2-Akt1 (zeige AKT1 Proteine) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (zeige SH3GL1 Proteine) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (zeige MAPK1 Proteine) pathway
ERK1 and ERK2 (zeige MAPK1 Proteine) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (zeige HSPA1A Proteine) in response to heat stress is dependent on ERK (zeige MAPK1 Proteine) activation in Pac2 (zeige PSMG2 Proteine) cells.
Data define distinct roles for ERK1 and ERK2 (zeige MAPK1 Proteine) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide and this process is related to the EGFR (zeige EGFR Proteine) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (zeige THBS1 Proteine), fibronectin (zeige FN1 Proteine), and vitronectin (zeige VTN Proteine) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Proteine) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Proteine) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (zeige MAPK1 Proteine).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (zeige BCL2L11 Proteine).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (zeige CSF2 Proteine) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (zeige MAPK1 Proteine)-dependent MTOR (zeige FRAP1 Proteine) signal transduction cascades.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK (zeige MAPK1 Proteine) activation mediated PPARgamma (zeige PPARG Proteine) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (zeige PRKAA1 Proteine)/ERK (zeige MAPK1 Proteine)/TSC2/mTOR (zeige FRAP1 Proteine) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Proteine)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (zeige MAPK14 Proteine) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (zeige IGF1 Proteine) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (zeige IGF1R Proteine)
The results suggest that the MPK-1 (zeige MAPK1 Proteine)/ERK (zeige MAPK1 Proteine) regulatory network, including FBF-1, FBF-2, and LIP-1 (zeige CENPJ Proteine), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (zeige FGFR3 Proteine) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (zeige SUV420H1 Proteine) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (zeige MAPK1 Proteine) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (zeige CDC42 Proteine) GTPase (zeige RACGAP1 Proteine).
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (zeige MAPK4 Proteine), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (zeige MAPK6 Proteine) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (zeige MAPK6 Proteine) can both interact with SPOROCYTELESS/NOZZLE (SPL (zeige SGPL1 Proteine)) in vitro and in vivo and can phosphorylate the SPL (zeige SGPL1 Proteine) protein in vitro.
MKK4 (zeige MAP2K4 Proteine), MKK5 (zeige MAP2K5 Proteine), MKK7 (zeige MAP2K7 Proteine), and MKK9, are responsible for the activation of MPK3 and MPK6 (zeige MAPK6 Proteine) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (zeige MAPK1 Proteine) signaling through MKK4 (zeige MAP2K4 Proteine)/5/7/9-MPK3/6 cascades.
Phosphatase AP2C1, as well as AP2C1-targeted MPK3 and MPK6 (zeige MAPK6 Proteine), are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.
Results demonstrated the contribution of MPK3 and MPK6 (zeige MAPK6 Proteine) to riboflavin-induced resistance.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 12
, MAPK 12
, extracellular signal-regulated kinase 6
, mitogen-activated protein kinase 12
, stress-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase