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High ERK1 expression is associated with gastric cancer.
Data suggest that Thr264 in TRPV3 (zeige TRPV3 Proteine) is key ERK1 phosphorylation site mediating EGFR (zeige EGFR Proteine)-induced sensitization of TRPV3 (zeige TRPV3 Proteine) to stimulate signaling pathways involved in regulating skin homeostasis. (TRPV3 (zeige TRPV3 Proteine) = transient receptor potential cation channel subfamily V member-3 (zeige TRPV3 Proteine); ERK1 = extracellular signal-regulated kinase-1; EGFR (zeige EGFR Proteine) = epidermal growth factor receptor (zeige EGFR Proteine))
Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.
These results demonstrate that betaine acts through ERK1/2-PPARgamma (zeige PPARG Proteine) signalling pathway to regulate lipid metabolism in adipogenic-differentiated skeletal muscle cells, which could provide some useful information for controlling muscle lipid accumulation by manipulating ERK1/2 and PPARgamma (zeige PPARG Proteine) signalling pathway.
The present study demonstrated that the downregulation of filaggrin (zeige FLG Proteine) in the epidermis by toluene is mediated by ERK1/2 and STAT3 (zeige STAT3 Proteine)-dependent pathways.
RASSF7 promotes cell proliferation through activating MEK1 (zeige MAP2K1 Proteine)/MEK2 (zeige MAP2K2 Proteine)-ERK1/ERK2 (zeige MAPK1 Proteine) signaling pathway in hepatocellular carcinoma.
SHP-2 (zeige PTPN11 Proteine) may augment the ERK1/2 activity and cell proliferation activity in IL-21 (zeige IL17C Proteine) signaling.
intact keratin filaments are regulators for PKB/Akt (zeige AKT1 Proteine) and p44 (zeige GTF2H2 Proteine)/42 activity, basal and in response to stretch.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (zeige CRK Proteine)/TRAF-6 (zeige TRAF6 Proteine)/ERK (zeige EPHB2 Proteine) MAP kinases pathways has been reported.
Integrated ERK1/ERK2 (zeige MAPK1 Proteine) response to B (zeige TDO2 Proteine)-cell receptor stimulation and SF3B1 (zeige SF3B2 Proteine) gene mutations refine prognosis in chronic lymphocytic leukemia.
M-CSF (zeige CSF1R Proteine)-evoked ERK1/2 activation was decreased, whereas AKT (zeige AKT1 Proteine) activation was enhanced in SHP2 (zeige PTPN11 Proteine)-deficient BMMs. ERK1/2, via its downstream target RSK2 (zeige RPS6KA3 Proteine), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (zeige CSF1R Proteine) receptor at Tyr721 and, consequently, its binding to p85 (zeige ECM1 Proteine) subunit of PI3K and PI3K activation.
Low ERK1 Phosphorylation is associated with low liver regeneration.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
In a retinitis pigmentosa mouse model, TrkC (zeige NTRK3 Proteine) activity generates phosphorylated Erk (zeige EPHB2 Proteine), which upregulates glial TNF-alpha (zeige TNF Proteine), causing selective neuronal death.
A. fumigatus increased PAR-2 expression and elevated disease, PMN infiltration, and proinflammatory cytokine expreERK1 Kinasession through PAR-2, which may be modified by p-ERK1/2.
ERK1 and ERK2 (zeige MAPK1 Proteine) play specific roles in beta cells. ERK2 (zeige MAPK1 Proteine) cannot always compensate for the lack of ERK1 but the absence of a clear-cut phenotype in Erk1 (-/-) mice shows that ERK1 is dispensable in normal conditions.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (zeige CRK Proteine) Pathways and the Interaction with Cell-Surface-HSP70 (zeige HSP70 Proteine).
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.
ERK1 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (zeige CRK Proteine) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (zeige MAPK8 Proteine) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
MAPK3 role in the oocyte maturation
ERK1/2-Akt1 (zeige AKT1 Proteine) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (zeige SH3GL1 Proteine) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (zeige MAPK1 Proteine) pathway
ERK1 and ERK2 (zeige MAPK1 Proteine) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (zeige HSPA1A Proteine) in response to heat stress is dependent on ERK (zeige MAPK1 Proteine) activation in Pac2 (zeige PSMG2 Proteine) cells.
Data define distinct roles for ERK1 and ERK2 (zeige MAPK1 Proteine) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide and this process is related to the EGFR (zeige EGFR Proteine) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (zeige THBS1 Proteine), fibronectin (zeige FN1 Proteine), and vitronectin (zeige VTN Proteine) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Proteine) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Proteine) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (zeige MAPK1 Proteine).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (zeige BCL2L11 Proteine).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (zeige CSF2 Proteine) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (zeige MAPK1 Proteine)-dependent MTOR (zeige FRAP1 Proteine) signal transduction cascades.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK (zeige MAPK1 Proteine) activation mediated PPARgamma (zeige PPARG Proteine) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (zeige PRKAA1 Proteine)/ERK (zeige MAPK1 Proteine)/TSC2/mTOR (zeige FRAP1 Proteine) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Proteine)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (zeige MAPK14 Proteine) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (zeige IGF1 Proteine) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (zeige IGF1R Proteine)
The results suggest that the MPK-1 (zeige MAPK1 Proteine)/ERK (zeige MAPK1 Proteine) regulatory network, including FBF-1, FBF-2, and LIP-1 (zeige CENPJ Proteine), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (zeige FGFR3 Proteine) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (zeige SUV420H1 Proteine) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (zeige MAPK1 Proteine) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (zeige CDC42 Proteine) GTPase (zeige RACGAP1 Proteine).
abscisic acid and jasmonate mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 and MPK6 (zeige MAPK6 Proteine), in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1 (zeige SPINT1 Proteine), HAI2 (zeige SPINT2 Proteine), and HAI3 through ABF/AREB transcription factors
Constitutive active-MPK3 plants are more resistant to the hemibiotrophic pathogen Pseudomonas syringae DC3000.
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (zeige MAPK4 Proteine), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (zeige MAPK6 Proteine) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (zeige MAPK6 Proteine) can both interact with SPOROCYTELESS/NOZZLE (SPL (zeige SGPL1 Proteine)) in vitro and in vivo and can phosphorylate the SPL (zeige SGPL1 Proteine) protein in vitro.
MKK4 (zeige MAP2K4 Proteine), MKK5 (zeige MAP2K5 Proteine), MKK7 (zeige MAP2K7 Proteine), and MKK9, are responsible for the activation of MPK3 and MPK6 (zeige MAPK6 Proteine) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (zeige MAPK1 Proteine) signaling through MKK4 (zeige MAP2K4 Proteine)/5/7/9-MPK3/6 cascades.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase