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anti-Human MAPK14 Antikörper:
anti-Rat (Rattus) MAPK14 Antikörper:
anti-Mouse (Murine) MAPK14 Antikörper:
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Human Polyclonal MAPK14 Primary Antibody für FACS, IF - ABIN1882176
Cheung, Campbell, Nebreda, Cohen: Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. in The EMBO journal 2003
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Human Monoclonal MAPK14 Primary Antibody für ICC, FACS - ABIN1724830
Li, Zheng, Li, Ma: Unfractionated heparin inhibits lipopolysaccharide-induced inflammatory response through blocking p38 MAPK and NF-?B activation on endothelial cell. in Cytokine 2012
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Human Monoclonal MAPK14 Primary Antibody für IHC, ELISA - ABIN1724904
Chung, Tang, Sun, Chou, Yeh, Yu, Sun: Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
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p38 (zeige CRK Antikörper) capital EM, Cyrilliccapital A, Cyrilliccapital ER, Cyrilliccapital KA, Cyrillic participates in the pathogenesis of epithelial-to-mesenchymal transition through Wnt (zeige WNT2 Antikörper) pathway.
The Cox (zeige COX8A Antikörper) proportional hazard models revealed that IL12Rb2 (zeige IL12RB2 Antikörper) and p38MAPK predicted a long OS. To the best of our knowledge, the present study is the first to reveal a close association between IL12Rb2 (zeige IL12RB2 Antikörper) and p38MAPK, and their possible function in nonsmall cell lung cancer progression
Data show that miR (zeige MLXIP Antikörper)-625-3p induces oxaliplatin resistance by abrogating MAP2K6 (zeige MAP2K6 Antikörper)-p38 (zeige CRK Antikörper)-regulated apoptosis and cell cycle control networks.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (zeige CRK Antikörper)/TRAF-6 (zeige TRAF6 Antikörper)/ERK (zeige EPHB2 Antikörper) MAP kinases pathways has been reported.
The cytotoxicity induced by EB1 (zeige MAPRE2 Antikörper) gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase..this signaling cascade, however not nuclear factor-kappaB-mediated signaling, induced the expression of cyclooxygenase-2 (zeige PTGS2 Antikörper), a key effector of apoptotic death.
Data, including data using network analysis, suggest that angiotensinogen (AGT (zeige AGT Antikörper)), mitogen-activated protein kinase-14 (MAPK14), and prothrombin (zeige F2 Antikörper) (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
The role of p38 MAP kinase signaling in metastatic clear cell renal cell carcinoma (zeige MOK Antikörper)
Rhythmic luciferase activity from clock gene luciferase reporter cells lines was used to test the effect of p38 MAPK inhibition on clock properties as determined using the damped sine fit and Levenberg-Marquardt algorithm.Glioma treatment with p38 MAPK inhibitors may be more effective and less toxic if administered at the appropriate time of the day.
Hsp27 (zeige HSPB1 Antikörper) and P38MAPK could be used as prognostic factors in Esophageal squamous cell carcinoma.
High p38MAPK expression is associated with non-small cell lung cancer metastasis.
P38 and JNK (zeige MAPK8 Antikörper) have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Adult zebrafish cardiomyocytes express active p38alpha MAPK (zeige MAPK1 Antikörper), which is switched off upon entry into mitosis.
Dkk3r regulates p38a phosphorylation to maintain Smad4 (zeige SMAD4 Antikörper) stability, in turn enabling the Smad2 (zeige SMAD2 Antikörper).Smad3a.Smad4 complex to form and activate the myf5 (zeige MYF5 Antikörper) promoter.
results suggest that ET-1 (zeige EDN1 Antikörper)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (zeige NOX1 Antikörper)-PKCalpha (zeige PKCa Antikörper)-p(38)MAPK (zeige MAPK1 Antikörper) and NFkappaB-MT1MMP (zeige MMP14 Antikörper) signaling pathways along with a marked decrease in TIMP-2 (zeige TIMP2 Antikörper) expression in the cells
cross-talk between p(38)MAPK (zeige MAPK1 Antikörper) and Gialpha play a pivotal role for full activation of cPLA2 (zeige PLA2G4A Antikörper) during ET-1 (zeige EDN1 Antikörper) stimulation of pulmonary artery smooth muscle cells.
MAPK14 signalling pathway is largely involved in heat-induced sperm damage.
p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.
Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.
p38 phosphorylation and MMP13 (zeige MMP13 Antikörper) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data suggest that the p38 and JNK (zeige MAPK8 Antikörper) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter (zeige SLC12A1 Antikörper) involves activation of p38 and JNK (zeige MAPK8 Antikörper) MAPKs
These data suggest a differential requirement of JNK1 (zeige MAPK8 Antikörper) and p38 MAPK in TNF (zeige TNF Antikörper) regulation of E2F1 (zeige E2F1 Antikörper). Targeted inactivation of JNK1 (zeige MAPK8 Antikörper) at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (zeige TNF Antikörper)-mediated EC dysfunction.
p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.
These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK (zeige JAK3 Antikörper) signalling in a Drosophila model of Myeloproliferative neoplasms.
ROS (zeige ROS1 Antikörper)/JNK (zeige MAPK8 Antikörper)/p38/Upd (zeige UROD Antikörper) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.
Data show that the genetic interaction between p38b MAPK (zeige MAPK1 Antikörper) and Rack1 (zeige GNB2L1 Antikörper) controls muscle aggregate formation, locomotor function, and longevity.
The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase (zeige MAPK1 Antikörper) can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.
found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles
Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.
The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.
p38b MAPK (zeige MAPK1 Antikörper) plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.
the D-p38b gene is regulated by the DREF (zeige ZBED1 Antikörper) pathway and DREF (zeige ZBED1 Antikörper) is involved in the regulation of proliferation and differentiation of Drosophila ISCs (zeige NFS1 Antikörper) and progenitors
These findings uncovered the molecular mechanisms by which p38alpha MAPK (zeige MAPK1 Antikörper) regulates osteoclastogenesis and coordinates osteoclastogenesis and osteoblastogenesis.
Praja1 (zeige PJA1 Antikörper) promotes skeletal myogenesis through degradation of EZH2 (zeige EZH2 Antikörper) upon p38alpha activation.
These results suggested that the thrombinstimulated synthesis of IL6 (zeige IL6 Antikörper) was limited by HSP90 (zeige HSP90 Antikörper) in osteoblasts, and that the effects of HSP90 (zeige HSP90 Antikörper) were exerted at the point between Rhokinase and p38 MAPK.
Overall, the authors showed that CCN1 (zeige CCNA2 Antikörper) increased IL-1beta (zeige IL1B Antikörper) production via p38 MAPK signaling, indicating a role for CCN1 (zeige CCNA2 Antikörper) protein in regulating inflammation in psoriasis.
we have identified novel interaction between p38 MAPK and Runx2 (zeige RUNX2 Antikörper) enhances Runx2 (zeige RUNX2 Antikörper) transactivity, thus promoting vascular smooth muscle cells calcification
p38alpha MAPK (zeige MAPK1 Antikörper) maintains the expression of antioxidant genes in liver of young animals via NF-kappaBeta (zeige NFKB1 Antikörper) under basal conditions, whereas its long-term deficiency triggers compensatory up-regulation of antioxidant enzymes through NF-kappaBeta (zeige NFKB1 Antikörper).
the present findings suggested that artesunate may exert protective effects against cerebral ischemia/reperfusion injury through the suppression of oxidative and inflammatory processes, via activating Nrf2 (zeige NFE2L2 Antikörper) and downregulating ROSdependent p38 MAPK in mice.
Results show that the p38 MAPK signaling pathway could regulate mitochondria Abeta (zeige APP Antikörper) internalization by manipulating the expression of alpha7nAChR. Pretreatment of alpha7nAChR agonist could attenuate these biochemical changes which are tightly associated with Abeta1-42 induced apoptosis. Suggesting there is an endogenous, previously unrecognized cholinergic mechanism to control mitochondria functions and their apoptotic ...
Prdx1 (zeige PRDX1 Antikörper) knockout can aggravate the oxidative stress and lung injury by increasing the level of Reactive Oxygen Species (ROS (zeige ROS1 Antikörper)), and also activate P38 (zeige CRK Antikörper)/JNK (zeige MAPK8 Antikörper) signaling pathway.
P38 (zeige CRK Antikörper) kinase role in the inflammatory pain.CXCL13, upregulated by peripheral inflammation, acts on CXCR5 (zeige CXCR5 Antikörper) on dorsal root ganglia neurons and activates p38 (zeige CRK Antikörper), which increases Nav1.8 (zeige SCN10A Antikörper) current density and further contributes to the maintenance of inflammatory pain.
cytochrome c (zeige CYCS Antikörper) microinjection induces p38 phosphorylation through caspase-3 (zeige CASP3 Antikörper) activation, and caspase (zeige CASP3 Antikörper) inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock
p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.
p38 Mitogen-activated protein kinase (MAPK (zeige MAPK1 Antikörper)) is essential for drug-induced COX-2 (zeige PTGS2 Antikörper) expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.
These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.
Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.
The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1 (zeige SIRT1 Antikörper)/Nrf2 (zeige NFE2L2 Antikörper) and p38 MAPK pathways.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 (zeige IL10 Antikörper) production through p38 MAPK activation.
JNK (zeige MAPK8 Antikörper) plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
These findings suggest that the TQ-induced production of ROS (zeige ROS1 Antikörper) causes dedifferentiation through the ERK (zeige MAPK1 Antikörper) pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.
These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB (zeige NFKB1 Antikörper), p53 (zeige TP53 Antikörper) and caspase-3 (zeige CASP3 Antikörper) activation.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Csaids binding protein
, MAP kinase 14
, MAP kinase 2
, MAP kinase Mxi2
, MAP kinase p38 alpha
, MAPK 14
, MAX-interacting protein 2
, cytokine suppressive anti-inflammatory drug binding protein
, cytokine-supressive anti-inflammatory drug binding protein
, mitogen-activated protein kinase 14
, mitogen-activated protein kinase 14A
, mitogen-activated protein kinase p38 alpha
, p38 MAP kinase
, p38 mitogen activated protein kinase
, p38alpha Exip
, reactive kinase
, stress-activated protein kinase 2A
, MAP kinase 14B
, MAP kinase p38b
, MAPK 14B
, mitogen-activated protein kinase 14B
, mitogen-activated protein kinase p38b
, p38 mitogen-activated protein kinase
, stress-activated p38b MAP kinase
, cytokine suppressive anti-inflammatory drug binding protein 1
, mitogen activated protein kinase 14
, p38 MAP kinase alpha
, p38 MAPK
, p38 alpha
, tRNA synthetase cofactor p38
, MAPK p38
, Mitogen-activated protein kinase 2
, mitogen-activated Mitogen-activated protein kinase 2
, p38 mitogen-activated kinase
, CSAIDS-binding protein 1
, stress-activated protein kinase 2a
, MAP kinase 14A
, MAP kinase p38a
, MAPK 14A
, Mitogen-activated protein kinase p38a
, mitogen-activated protein kinase p38a