anti-MAP3K3 (MAP3K3) Antikörper

Human Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3) Interaktionspartner

1. MEKK3 KO reduced both EMT (zeige ITK Antikörper) and cell migration, the size of 3D colonies and the percentage of CD44 (zeige CD44 Antikörper)(+)/CD24 (zeige CD24 Antikörper)(+)/EpCAM (zeige EPCAM Antikörper)(+) CSC, promoter recruitment of YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) and the expression of their target genes.

2. All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain (zeige ITSN1 Antikörper), which may mediate the intermolecular recognition between hPTTG1 and MAP3K.

3. Polymorphisms in MAP3K3, MMP24 (zeige MMP24 Antikörper) and IGF1R (zeige IGF1R Antikörper) are associated with greater height and act additively on height in children of an admixed population.

4. MAP3K3 overexpression is an independent poor prognostic indicator in ovarian carcinoma.

5. MAP3K3 may potentially not only serve as diagnostic/prognostic markers for patients with lung cancer but also provide an indicator for future investigations into immunomodulatory therapies for lung cancer.

6. studies identify gain of MEKK3 signallin (zeige KLF2 Antikörper)g and KL (zeige KLF4 Antikörper)F2/4 function as causal mechanisms for cerebral cavernous malformations pathogenesis that may be targeted to develop new CCM therapeutics

7. High MEKK3 expression is associated with renal clear cell carcinoma.

8. MEKK3 expression was significantly higher in patients with renal clear cell carcinoma than in controls.

9. This (zeige NBR1 Antikörper) study identified an NBR1-MEKK3 complex as a key regulator of JNK s (zeige NBR1 Antikörper)ignaling and adipose tissue inflam (zeige MAPK8 Antikörper)mation in obesity.

10. Our finding that Verrucous venous malformation contains a MAP3K3 mutation supports our impression that this lesion is a venous anomaly.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3) Interaktionspartner

1. MiR (zeige MLXIP Antikörper)-188 regulated MAP3K3 expression in bone marrow cells.MAP3K3 is involved in miR (zeige MLXIP Antikörper)-188-induced promotion of bone marrow cells senescence.

2. this study shows that TAK1 (zeige NR2C2 Antikörper) negatively regulates lipopolysaccharide-induced cytokine secretion in myeloid cells by inhibiting MEKK3 activities

3. endothelial-specific loss of Mekk3, Klf2 (zeige KLF2 Antikörper) or Klf4 (zeige KLF4 Antikörper) markedly prevents cerebral cavernous malformation lesion formation, reverses the increase in Rho activity, and rescues lethality

4. CCM2 (zeige CCM2 Antikörper):MEKK3-mediated regulation of Rho-ROCK signalling is required for maintenance of neurovascular integrity, a mechanism by which CCM2 (zeige CCM2 Antikörper) loss leads to disease.

5. NBR1 (zeige NBR1 Antikörper) is increased in adipose tissue macrophages in obese mice. The NBR1 (zeige NBR1 Antikörper)-MEKK3 complex is important in JNK (zeige MAPK8 Antikörper) activation in macrophages.

6. MEKK2 (zeige MAP3K2 Antikörper) alone can suppress T-cell TGF-beta (zeige TGFB1 Antikörper) responses. MEKK2 (zeige MAP3K2 Antikörper) or MEKK3 can cause ERK1/2 to phosphorylate SMAD2 (zeige SMAD2 Antikörper)/3 and suppress R-SMAD (zeige SMAD1 Antikörper)-dependent transcription. MEKK2 (zeige MAP3K2 Antikörper) and MEKK3 play overlapping roles in regulating Th-cell differentiation via TGF-beta (zeige TGFB1 Antikörper)

7. Using Mekk3-deficient murine T cells, the authors concluded MEKK3 expression is required for mounting optimal T cell responses in vivo and is involved in mediating the TCR-dependent Rac1 (zeige RAC1 Antikörper)/2 signals for IFN-gamma (zeige IFNG Antikörper) production through the MAPK (zeige MAPK1 Antikörper) pathways.

8. The signaling defect of elevated interleukin (IL)-12 (zeige IL12A Antikörper) overproducing cells in nonobese diabetic mice could be attributed to, at least partially, the overexpression of a single MAP3K, namely MEKK3.

9. Strikingly, chimeric mice transplanted with Mekk3(Deltaflox/-) BM exhibited a reduction in tumor growth and vessel density compared with mice transplanted with Mekk3(Deltaflox/+) BM cells.

10. PB1 (zeige GPR97 Antikörper) domain mediates the association of MEKK2 (zeige MAP3K2 Antikörper) and MEKK3 with MEK5 (zeige MAP2K5 Antikörper) and that the respective PB1 (zeige GPR97 Antikörper) domains of these kinases are critical for regulation of the ERK5 (zeige MAPK7 Antikörper) pathway.