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MKK4 overexpression enhanced TNF-alpha (zeige TNF Proteine)-mediated signaling activation and transcription of downstream catabolic genes, and consequently worsened cartilage degradation.
Study provides evidence that phosphorylated MKK4 (pMKK4) might function as a tumor suppressor in colorectal cancer (CRC (zeige CALR Proteine)). Downregulation of pMKK4 was associated with a more aggressive phenotype and with increases in local invasion and metastasis. pMKK4 was also strongly associated with disease-free survival.
Androgen-induced miR (zeige MLXIP Proteine)-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression
the expression level of MAP2K4 was inversely associated with the expression of miR (zeige MLXIP Proteine)-802 in tongue squamous cell carcinoma (TSCC) tissues; demonstration that the MAP2K4 expression was upregulated in TSCC cell lines; elevated expression of miR (zeige MLXIP Proteine)-802 inhibited TSCC cell viability and invasion through inhibiting MAP2K4 expression
MKK4 activates non-canonical NFkappaB (zeige NFKB1 Proteine) signaling by promoting NFkappaB2-p100 (zeige CUX1 Proteine) processing.
Manipulating the expression of both miR (zeige MLXIP Proteine)-222 and miR (zeige MLXIP Proteine)-25 influenced diverse gene expression changes in thyroid cells. Increased expression of miR (zeige MLXIP Proteine)-25 reduced MEK4 and TRAIL protein expression, and cell adhesion and apoptosis are important aspects of miR (zeige MLXIP Proteine)-25 functioning in thyroid cells.
These results suggest that ROCK may be important in IL-1 (zeige IL1A Proteine)-induced signaling through MKK4 to JNK (zeige MAPK8 Proteine) and the activation of p38 MAPK (zeige MAPK14 Proteine).
Association between MKK4 promoter polymorphism and breast cancer risk in Kashmiri population
In Chinese Han ischemic stroke patients rs3826392 C/A genotype carriers showed significantly higher IL-1b (zeige IL1B Proteine) serum levels.
The plasma level of protein MAP2K4 was found to suggestively associate negatively with the volume of the left entorhinal cortex in asymptomatic older twins.
MKK4 is the major MAP2K, which activates JNK (zeige MAPK8 Proteine) in acute liver injury. p38 (zeige CRK Proteine), the other downstream target of MKK4, does not contribute to liver injury from APAP or TNF (zeige TNF Proteine)/galactosamine.
MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 (zeige PATL2 Proteine) processing.
Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 (zeige TGFB1 Proteine) signaling associated with atrial remodeling and arrhythmogenesis with age.
This study provides compelling evidence for the pivotal roles of the ZPK/DLK (zeige MAP3K12 Proteine) and MKK4/MAP2K4-dependent mechanism in axotomy-induced motoneuron death in neonates.
The loss of mkk4 and mkk7 (zeige MAP2K7 Proteine) locks damaged exocrine cells in a permanently de-differentiated state.
Studies identify the dual-specific kinase MKK4 as a master regulator of liver regeneration. MKK4 silencing robustly increased the regenerative capacity of hepatocytes in mouse models of liver regeneration and acute and chronic liver failure.
MicroRNA-92a negatively regulates Toll (zeige TLR4 Proteine)-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
MKK4/7 and JNK1 (zeige MAPK8 Proteine)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.
These data support a model in which MKK4 activation at the metastatic site causes a cell-cycle arrest.
in Drosophila both MAPKKs, Hep/Mkk7 (zeige MAP2K7 Proteine) and Mkk4, are required to induce JNK (zeige MAPK8 Proteine) upon TNF (zeige TNF Proteine) or pro-inflammatory stimulation
MKK4, MKK5 (zeige MAP2K5 Proteine), MKK7 (zeige MAP2K7 Proteine), and MKK9, are responsible for the activation of MPK3 (zeige MAPK3 Proteine) and MPK6 (zeige MAPK6 Proteine) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (zeige MAPK1 Proteine) signaling through MKK4/5/7/9-MPK3 (zeige MAPK3 Proteine)/6 cascades.
our data indicate that EDR1 physically associates with MKK4/MKK5 (zeige MAP2K5 Proteine) and negatively regulates the MAPK (zeige MAPK1 Proteine) cascade to fine-tune plant innate immunity.
Results suggest that the YDA-MKK4/MKK5 (zeige MAP2K5 Proteine)-MPK3 (zeige MAPK3 Proteine)/MPK6 (zeige MAPK6 Proteine) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK4 is involved in the osmotic-stress response via its regulation of MPK3 (zeige MAPK3 Proteine) activity.
MKK4 is a key regulator of stomatal development and patterning.
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
JNK activating kinase 1
, JNK-activated kinase 1
, JNK-activating kinase 1
, MAP kinase kinase 4
, MAPK/ERK kinase 4
, MAPKK 4
, MEK 4
, SAPK/ERK kinase 1
, c-Jun N-terminal kinase kinase 1
, dual specificity mitogen-activated protein kinase kinase 4
, stress-activated protein kinase kinase 1
, C-JUN N-terminal kinase kinase 1
, JNK kinase 1
, JNKK 1
, SAPK/Erk/kinase 1
, mitogen activated protein kinase kinase 4, variant 1
, mitogen-activated protein kinase kinase 4
, JNK kinase 2
, Map kinase kinase 4
, drosophila MAP kinase kinase 4