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Findings suggest that mitotic CDK1 (zeige CDK1 ELISA Kits)-directed phosphorylation of delta-4E-BP1 may yield a gain of function, distinct from translation regulation, that may be important in tumorigenesis and mitotic centrosome function.
p4EBP1 was independently predictive for pathologic complete response in PIK3CA (zeige PIK3CA ELISA Kits) wild-type tumors.
Data show that 4EGI-1 compound induced apoptosis in nasopharyngeal carcinoma cells through the death receptor 5 (DR5 (zeige TNFRSF10B ELISA Kits)) on 4E-BP1 dephosphorylation exerting positive influence on their anti-tumor activities.
There were significantly higher expressions of p-eIF4E (zeige EIF4E ELISA Kits) and p-4EBP-1 proteins in the cases with lymph node metastasis than in those without lymph node metastasis.
4E-BP1 has tumor suppressor activity by inhibiting eIF4E (zeige EIF4E ELISA Kits) and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1, which are detected in various cancers
Rotterlin inhibits mTORC1 and 4EBP1 activity in melanoma cells, inhibiting protein synthesis and promoting cell death.
Inhibition of mTORC1-mediated 4EBP1 phosphorylation leads to decreased expression of c-MYC (zeige MYC ELISA Kits) and subsequent upregulation of the proapoptotic BCL2 (zeige BCL2 ELISA Kits) family member PUMA (zeige BBC3 ELISA Kits), whereas inhibition of mTORC2 (zeige CRTC2 ELISA Kits) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (zeige EGR1 ELISA Kits)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (zeige BCL2L11 ELISA Kits) locus encoding BIM (zeige BCL2L11 ELISA Kits).
p-4E-BP1 is more highly expressed in early gastric cancers than in advanced ones, and has limited potential as an independent prognostic biomarker in patients with gastric cancer.
this study shows that anticancer activity of perillyl alcohol is mediated via inhibition of 4E-BP1 signaling
4EBP1 may serve as a funnel factor that converge the upstream proliferative oncogenic signals.
decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1.
we show that simultaneous inhibition of mTOR (zeige FRAP1 ELISA Kits) signaling to both S6K1 (zeige RPS6KB1 ELISA Kits) and 4E-BP1 is sufficient to reduce AKT (zeige AKT1 ELISA Kits)-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin
4E-BP1 is a gender-specific suppressor of obesity that regulates insulin (zeige INS ELISA Kits) sensitivity and energy metabolism.
The authors now show that West Nile virus growth and protein expression are dependent on mTORC1 mediated-regulation of the eukaryotic translation initiation factor 4E-binding protein/eukaryotic translation initiation factor 4E-binding protein (4EBP/eIF4E (zeige EIF4E ELISA Kits)) interaction and eukaryotic initiation factor (zeige EIF4G1 ELISA Kits) 4F (eIF4F (zeige EIF4A2 ELISA Kits)) complex formation to support viral growth and viral protein expression.
p-mTOR, p-4EBP1, HIF-1alpha and VEGF together are involved in the pathogenesis of asthma.
Thus, translational control by 4E-BP1 downstream of mTOR (zeige FRAP1 ELISA Kits) effects the expression of neuroligin 1 (zeige NLGN1 ELISA Kits) and excitatory synaptic transmission in the spinal cord, and thereby contributes to enhanced mechanical nociception.
The findings support a model whereby elevated 4E-BP1 expression observed in the retina of diabetic rodents is the result of O-GlcNAcylation of 4E-BP1 within its PEST motif.
The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
Oxidative stress-induced (zeige SQSTM1 ELISA Kits) premature senescence occurred due to impaired autophagy function through 4EBP1 phosphorylation.
Data show that deletion of eukaryotic translation initiation factor 4E-binding protein 1/2 (4E-BP1/2) in erythroid cells rendered them resistant to mammalian target of rapamycin complex 1 (TORC1) inhibition and restored hemoglobin production.
Here, the authors show that cell autonomous insulin (zeige INS ELISA Kits) signaling within the Drosophila CM9 motor neuron regulates the release of neurotransmitter via alteration of the synaptic vesicle fusion machinery. This effect of insulin (zeige INS ELISA Kits) utilizes the FOXO-dependent regulation of the thor gene, which encodes the Drosophila homologue of the eif-4e binding protein (4eBP).
GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
longevity assurance mutants of chico, the Drosophila insulin receptor (zeige INSR ELISA Kits) substrate homolog, require Drosophila d4eBP to slow aging.
These results indicate that the Ccr4-Not complex controls expression of 4E-BP at multiple levels and adjusts the magnitude of the total effect.
eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E (zeige EIF4E ELISA Kits) to repress translation.
PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression
These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging.
Induction of 4EBP likely leads to growth inhibition by Dfoxo, whereas activation of InR (zeige INSR ELISA Kits) provides a novel transcriptionally induced feedback control mechanism.
S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target of rapamycin (TOR) signaling pathways.
Drosophila 4E-BP activity becomes critical for survival under dietary restriction and oxidative stress, and is linked to life span.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR (zeige FRAP1 ELISA Kits)-RPS6K-RPS6 (zeige RPS6 ELISA Kits)-EIF4EBP1 signal transduction pathway.
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
eIF4E-binding protein 1
, eukaryotic translation initiation factor 4E-binding protein 1
, phosphorylated heat- and acid-stable protein regulated by insulin 1
, Eif4e-binding protein
, eIF-4E-binding protein
, eif4e-binding protein 4EBP
, eukaryotic initiation factor 4E binding protein
, eukaryotic initiation factor 4E-binding protein
, eukaryotic translation initiation factor 4E binding protein
, eukaryotic translation initiation factor 4E-binding protein
, insulin-stimulated eIF-4E binding protein
, lethal (2) 06270
, eukaryotic translation initiation factor 4E binding protein 1
, translation initiation factor 4E binding protein 1